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Candida auris escapes innate immunity through metabolic reprogramming
A team of scientists from Australia and Israel demonstrates that Candida auris, a fungus associated with life-threatening and drug-resistant infections, escapes the host's innate immune response by destroying macrophages through metabolic reprogramming. The fungus is also capable of escaping antimicrobial inflammatory response.
Genes known to control eye color are essential for retinal health
Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.
Antifungal tolerance in Candida auris contributes to treatment failure
A recent study published in the journal Biomedicines aimed to determine the antifungal tolerance of Candida auris  (C. auris) to all three classes of antifungal drugs commonly used to treat invasive candidiasis.
High-resolution mass spectrometric rapid identification of Candida auris
A recent study published in the Journal of Fungi used a novel OrbitrapTM high-resolution mass spectrometric technology coupled with liquid chromatography to identify geographically different clades of Candida auris (C. auris) isolates. This proof-of-concept methodology could accurately detect C. auris in the microbiology laboratory.
Candida auris infection without epidemiologic links to a prior outbreak
The Centers for Disease Control and Prevention (CDC) has classified Candida auris (C. auris) as an urgent public threat due to its role in elevating mortality, its ability to persist in hospital environments, and the high possibility of developing pan-drug resistance.
Comparison of food portion sizes across Europe
An Italian study has recently compared the standard portion sizes for different food categories in European countries. The study identifies a wide variation between countries regarding their importance for food, nutrient, and energy consumption.
Biological BMI measures metabolic health more accurately
Researchers analyze longitudinal and cross-sectional changes in blood analytes associated with variations in body mass index.
U.S. maternal mortality rates rose during COVID-19 pandemic
A new study examines mortality related to pregnancy during the COVID-19 pandemic as compared pre-pandemic rates.
New report highlights changing demographics of autism in the United States
A new report from the Centers for Disease Control and Prevention (CDC) shows the rates and demographics of children with autism spectrum disorder (ASD) are changing in the United States.
Exploring the complexities of antimicrobial resistance forecasting
Researchers highlight the need for prioritizing research on antimicrobial-resistant organism forecasting.
'We're Struggling': Long COVID Mystery Has Doctors in the Dark
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The lack of knowledge regarding long COVID makes it difficult for doctors to counsel patients on how long symptoms will last, why they are experiencing it, or what its actual cause is.

Handling Emotions After Breast Cancer
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Post-cancer stress following breast cancer is real. Learn how it can affect you and what you can do about it.

Handling Emotions After Breast Cancer
photo of anxious mature woman

Post-cancer stress following breast cancer is real. Learn how it can affect you and what you can do about it.

Running Long Distances Might Not Hurt Your Joints After All
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It has generally been thought that running could increase the risk of osteoarthritis because it puts more load on joints than walking or standing.

Teens Heal Differently Than Adults After Concussion
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Teens experience many of the same symptoms of concussions as adults, but they may be worse, and take longer to end.

AMD and Vision Loss: One Woman’s Story of Acceptance

What's it like to deal with vision loss from wet AMD? Find out how one woman has learned to adapt.

Learning to Live With AMD: A Caregiver’s Story

Her father's AMD diagnosis was hard for them both. Learn how this caregiver helped her loved one deal with vision loss.

How Can Cognitive Behavioral Therapy (CBT) Help With Weight Management?

In the webinar “How Can CBT Help With Weight Management,” Rachel Goldman, PhD, shared some tools that can help you work toward a healthier weight.

Similar Processes Could Link MS With Heart Disease

Multiple sclerosis and atherosclerosis both involve an abnormal hardening of body tissue, and recent research suggests they may be linked.

After Breast Cancer: Fitness and Nutrition Tips
photo of woman stretching outdoors

Get back into exercise and adopt a diet rich in cancer-protective foods, which will boost your health and may even help prevent breast cancer from coming back.

After Breast Cancer: Fitness and Nutrition Tips
photo of woman stretching outdoors

Get back into exercise and adopt a diet rich in cancer-protective foods, which will boost your health and may even help prevent breast cancer from coming back.

Seniors With Few Years Left Often Advised to Get Colonoscopy
photo of gastroenterologist performing colonoscopy

Some polyps, if allowed to grow, have the potential to develop into cancer, a transformation that can take 10 to 15 years. This long timeline highlights the importance of considering life expectancy in deciding which patients should have a repeat colonoscopy.

Common Chemical Linked to Parkinson’s Disease
photo of mri scans of brain

According to a new paper by an international team of scientists, the chemical known as TCE may be associated with as much as a 500% increased risk for Parkinson’s disease.

Old-School Printer Helps Scientists Spot Bacteria in Blood
photo of medical illustration blood bacteria red f

A faster way to identify bacterial infection in blood combines nanoparticles, AI, and ink-jet printer technology.

Military Pilots, Ground Crew at Higher Risk of Cancer
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A study from the Department of Defense found that military air and ground crew have an increased rates of cancer when compared to the general population, but they were not more likely to die from cancer.

Can Laws Be Medicines?
photo of seatbelt sign

How the field of legal epidemiology uses rigorous scientific methods to investigate the link between policy and public health.

Mediterranean Diet Greatly Reduces Heart Disease Risk in Women
photo of Mediterranean salad

Those who closely followed a Mediterranean diet had a 24% lower risk of heart disease and 23% lower risk of death overtime compared with those following other kinds of diets.

Older Men More at Risk as Dangerous Falls Rise for All Seniors
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For the older population, falls are a major health hazard.

High Caffeine Levels Linked to Lower Body Fat, Diabetes Risk
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Having a higher level of caffeine in your blood could reduce body fat and the risk of type 2 diabetes, according to a new study published in BMJ Medicine.

It's (Finally) Time to Stop Calling It a Pandemic: Experts
lungs coronavirus

Many experts say we have entered a new phase as health care crises seem to have quieted and the public has moved on to endemic behavior. Others say it's too soon to label COVID trajectory predictable.

- Alice Ferng
Levels Is Making Metabolism and Blood Glucose Tracking Accessible To Everyone

Levels has done something truly transformative: the company made continuous glucose monitors (CGMs) accessible to the general population and every day consumer.

In many circles, it seems the trend of bringing healthcare to the home and directly to the patient is continuing, but understanding metabolism and lifestyle habits through this new tech trend of smart, wearable devices adds another important component to enjoying improved health and well-being.

If you imagine your body as a well-oiled machine that needs to be maintained, the sources of fuel and nutrition that you provide it are paramount for its efficiency and optimization. The first step to achieving this is understanding how your body processes different types of foods – each person is different and there is no “one-size-fits-all” when it comes to health and nutrition.

However, getting a handle on the biochemical processes behind how food is broken down and used within the body can seem a daunting task for many, and even for those who understand it, it’s not always possible to monitor with the aid of tech. This is where Levels has done an great job continuing to iterate on their app and device user experience, adding more metrics and useful pieces of information.

Why should you care about blood glucose?

Continuous glucose monitoring doesn’t only provide value to the usual population of diabetics. Many athletes have also used similar technologies to understand how to keep their bodies at peak performance.

Unlike for heart rate variability where a high variability is thought to be ideal, for good metabolic health you want to achieve low glycemic variability – in other words, “steady” glucose levels. For the healthy adult, glucose levels should remain somewhere between 70 mg/dL to 110 mg/dL at all times, and post-meal glucose should not rise over 30 mg/dL. However, according to the American Diabetes Association, anything below 140 mg/dL is considered normal.

What are the risks of high blood glucose? For one, potential insulin resistance. Insulin is the hormone that helps shuttle glucose to cells for energy, and resistance to insulin can ultimately result in prediabetes or type 2 diabetes. However, consistently high blood glucose levels can also lead to other types of potentially damaging physiological stress to the body in the form of oxidative stress, inflammation, and glycation — all of which contribute to chronic conditions, including cardiovascular disease, Alzheimer’s, and cancer.

In the short-term, big changes in sugar levels — that “sugar high” and “crash” people talk about — can result in feelings of anxiety, fatigue, irritability, inability to focus, and other common neurological feedback symptoms. And sustained response of any physiological stress over time can perpetuate symptoms and create even more problems.

What if you are healthy? Well, part of a “well-being plan” often involves a healthy diet and getting the right amount of nutrition. However, the impact of any type of diet varies widely from person to person, because every person’s body will metabolize foods in different ways. Having access to a CGM makes these insights accessible to everyone, and not just those that are prescribed a CGM only after a clinical diagnosis.

These are just some of the reasons it is so important to have an understanding of blood glucose and have a grasp on your own metabolic health.

What’s it like using Levels?

After testing out Levels app for over a month, I was able to have a much better understanding of how my body responds to different types of foods, stress, and even how quickly it metabolizes glucose during different types of workouts. I learned what types of foods cause a spike in my glucose levels and was also able to notice when high stress levels would result in markedly higher blood glucose levels under similar external conditions (foods, sleep, exercise, work schedule).

It’s definitely a product I would highly recommend to anyone wanting to have a better understanding of their diet and lifestyle — it quickly becomes a foundational part of your personalized health, especially if you’re into using health wearables to understand and optimize your own well-being.

One nice feature is an instant metabolic analysis a few hours after you’ve eaten, and insights daily and weekly to highlight the impact of diet and exercise. Some time spent doing reflection on these habits and diet can go a long way. Based on what I ate and did, I could also start to spot trends when juxtaposed with my sleep tracking data. As a result, I was able to make productive adjustments every week.

Part of the Levels experience includes an at-home metabolic health panel, where you set up an appointment at home and someone will come to take a blood sample to build out a metabolic panel. There are then options to consult professionals to further dial in your metabolism and health.

The Levels team has put out many excellent educational resources such as blog posts and articles, as well as a podcast that is fun to listen to during walks. There are many nuggets of information constantly shared via the app, such as the pro tip of taking a walk after a carb-heavy meal can help the body metabolize the meal, or food substitutions to optimize glucose stability.

There are four major blood glucose levers Levels constantly touches upon: diet, exercise, stress, and sleep. They have gamified metabolic metrics to include aspects of these levers in the tracking app, which helps make managing metabolic consistency more engaging.

Installation of the device itself is extremely fast and painless. The Dexcom CGM is a wearable biosensor that samples your blood sugar levels every five minutes and relays the information back to the app with a transmitter via Bluetooth. The transmitter itself lasts for at least 90 days. An applicator “injects” a tiny microfilament with the push of a button, and you don’t really feel a thing after that unless you explicitly push directly on the device where it is injected.

I tried wearing the CGM on my arm initially, but personally found that I was much more comfortable with it on my abdomen, even when sleeping and rolling around. After the second week, I stopped noticing it was there.

We had a chance to interview Dr. Lauren Kelley-Chew, Head of Clinical Product at Levels.

Alice Ferng, Medgadget: Tell us at a bit about yourself and your role at Levels. 

Dr. Lauren Kelley-Chew (Head of Clinical Product, Levels): I am the Head of Clinical Product at Levels. Prior to Levels, I led Strategy & BizOps at Verily Life Sciences, driving product, commercial, and clinical strategy with a focus on wearables, digital biomarkers, and emerging products. Previous to that, I founded a Y Combinator-backed digital therapeutics startup for digestive diseases and worked as a private equity investor. I graduated from medical school at UPenn, where I was a Gamble Scholar. Throughout my career, I have been inspired to build products and businesses that solve system-level problems and make good health accessible to everyone.

Medgadget: Can you help describe the values we’re reading as the consumer? For example, how does a meal impact blood glucose? How can it be expected to impact glucose? (I notice there’s been additional tips from the app and the daily analysis getting iterated on too).

Dr. Kelley-Chew: First, some background on glucose: Because glucose is a primary fuel source for our cells, how efficiently our body uses and processes it is vital to several areas of our health, from short-term energy and mood to long-term risk of chronic disease. Even if your annual labs put you in the range conventionally considered “healthy”, frequent blood sugar spikes and crashes can cause changes in your body that are detrimental to health in the short and long run.

The primary way our body gets glucose is through the food we eat, especially from carbohydrates. As that glucose moves into our bloodstream, a cascade of actions happen in our bodies to make sure it gets into our cells for energy or stored away for later use; the body aims to maintain a stable level. The reading in the Levels app is telling you how much glucose is in your blood right now. The sharpness and degree of rise you see from a meal depends on a number of factors, including how many carbs were in that meal, what kind of carbs (refined grains or sugars get absorbed more quickly, thus causing a sharper rise), what other foods you’ve eaten, how you’ve slept and more. 

Additionally, how our bodies respond to the levers that impact glucose—diet, exercise, sleep, stress—is highly individual. Foods that may cause a sudden spike for you may only cause a gentle rise for me. We don’t yet entirely know why this is the case—genetics, microbiome, and other confounding factors may all play a role—but it’s evident in research and our member data. That’s why simply reading a carb count on a label or looking up a food’s glycemic index, while helpful, doesn’t tell the whole story of how that food will affect your health.

For example, you may find that the mid-morning energy slump is just a blood-sugar crash following the spike caused by your morning bagel. Or that your afternoon anxiety results from very high glucose from lunch.

Levels can help visualize data readings in the context of target blood sugar range (for someone without diabetes) so you can immediately see if those changes in glucose are within an optimal range. It can also help you to see a full day’s glucose changes (as well as track overall trends over weeks and months) alongside meals, exercise and sleep so you can connect those changes to behavior. Additionally, you can save a catalog of foods and meals that work (or don’t work) for you and receive suggestions and guidance based on your data.

Medgadget: What sorts of updates to the app are ongoing to help folks understand their metabolism even more?

Dr. Kelley-Chew: We recently added a few features to our app to enhance the user experience:

Notification and insights surfaced to members and tailored to help them optimize their metabolic fitness  Implemented a new rewards system to keep members motivated and celebrate their progress towards goals We’ll continue to add more insights and education to the app over time, tied to your specific goals and journey. We also share deeply-reported, science-backed stories with members and non-members through our Metabolic Insights site and our bi-weekly newsletter and social channels.

Medgadget: Does where the sensor is placed impact the numbers (e.g., centrally vs peripherally, or arm vs stomach)? 

Dr. Kelley-Chew: CGMs are typically applied to either the abdomen or back of the arm (the fleshy part, between the tricep and deltoid muscles-avoiding the muscle) per manufacturer guidance. For accurate, consistent readings, we recommend using a consistent location (if the back of the arm, use the same arm) when changing sensors. While a CGM is always reading glucose from your interstitial fluid, it’s possible to see variation from sensor to sensor.  

Medgadget: What are some upcoming features we can look forward to? 

Dr. Kelley-Chew: Nothing we can share just yet, but stay tuned for some very exciting updates this year aiming to make improved metabolic health more accessible and actionable.

Medgadget: What are some upcoming partnerships or developments you’d like to highlight for Levels? 

Dr. Kelley-Chew: Though we launched it last year, we’re excited to continue to build on our observational research study, Glucose and Lifestyle Data Patterns in the General Population. The study, which our members can opt to join, explores the relationship between blood glucose and food, exercise, age, sex, and other lifestyle choices. In addition, it aims to characterize glucose patterns in people without diabetes. In 2022, more than 10,000 members signed up to participate, and more enroll each week. To our knowledge, this amounts to the largest ever study on this topic in people without diabetes and a huge citizen science effort. 


Product referral link…

Levels blog – a wealth of science-backed, reported articles about metabolic health, nutrition and physical fitness guidance

Levels podcast – A Whole New Level – conversations about metabolic health with leading researchers and scientists

Youtube Metabolic Menu playlist – metabolic-friendly, low spike recipes and cooking tutorials with co-founder and CMO, Dr. Casey Means

- Conn Hastings
CRISPR Combined with Glowing Proteins for Viral Detection

Researchers at Eindhoven University of Technology in the Netherlands have developed a sensitive diagnostic test for viral pathogens that is suitable for use in low-resource regions. The test is based on CRISPR proteins that can detect viral genetic material but also incorporates luciferase proteins, which are bioluminescent proteins that are naturally found in fireflies and other creatures. Two CRISPR/Cas proteins are specific for different parts of the viral genome, and when they both bind to target nucleic acid sequences they join together, uniting two fragments of luciferase and initiating a bioluminescent signal. The results can be appraised using a simple digital camera, meaning that the inexpensive technology may be suitable for use in low-resource regions.  

The COVID-19 pandemic created the societal pressures that often accompany technological breakthroughs, and we can see evidence of this in the rapid creation and adoption of new vaccines, propelling mRNA technologies into the open. However, diagnostic technologies have also made a leap forward, with a variety of approaches that have been developed to detect viruses.

While many such approaches are valuable, they are not useful in every corner of the world. For instance, low-resource and/or remote regions often lack the qualified healthcare staff or laboratory resources to use these technologies effectively. To address this, these researchers have developed a simple viral diagnostic assay that combines the sensitivity of more advanced clinical tests with ease of use and rapid results.

The technology employs the CRISPR/Cas gene editing system which can detect viral genetic material, such as that from the Sars-CoV-2 virus. However, conventional use of CRISPR/Cas requires multiple steps and sophisticated equipment, particularly if the amount of genetic material in the sample is very low. To make the system more user-friendly, the researchers combined CRISPR-Cas with luciferase, a naturally-occurring bioluminescent protein.

The researchers have called their technique LUNAS (luminescent nucleic acid sensor). The technology involves recombinase polymerase amplification, a method to amplify nucleic acids that does not require high temperatures or sophisticated thermocyclers, but works at a constant temperature of approximately 100 F (38 C).

The system also includes CRISPR-Cas proteins that are attached to a fragment of the luciferase protein. When the proteins bind the viral nucleic acids they also bind to each other, reuniting the luciferase fragments and sparking a burst of bioluminescence that can easily be appraised using a smartphone camera. Finally, the technology can provide a result in as little as 20 minutes.

Study in journal ACS Central Science: Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation

Via: American Chemical Society

- Medgadget Editors
Imagene Profiles Cancer Biomarkers in Real Time

Cancer therapies have proliferated over the past few decades, improving outcomes for many patients. But this variety requires accurate diagnostics and appropriate decision making to choose the optimal course of therapy. The current gold standard of identifying which cancer mutation is present is new generation sequencing (NGS), which provides a comprehensive genetic report, but can take up to six weeks to complete, requires a significant tumor sample size, and can only be done in an advanced laboratory at a high cost.

Imagene, a company headquartered in Tel Aviv, Israel, has developed AI-based image analysis software that analyzes digitized biopsy slide images to provide immediate tumor mutation profiling. Thanks to support from Biomed Israel, the leading international Life Science and HealthTech conference in Israel (see more below about the upcoming event), we had a chance to learn about Imagene’s technology from Dean Bitan, CEO and Co-Founder of the company.

Dean recounted how only two decades ago we only had access to one-size-fits-all treatments that were effective for some patients, but did nothing for others. Thanks to DNA sequencing and the ability to understand the DNA, and the bugs within it, which lead to mutations, it became possible to develop drugs that better target cancers. This is precision medicine, but it requires a long and complex process, a high cost, and biopsy samples that can be difficult to obtain. This is very difficult psychologically for the the patient (and doctor) to wait for a long time to obtain results and not start treatment, as the cancer can deteriorate while waiting.

Imagene was founded in 2020 to make use of the capabilities of AI to be able to identify a variety of biomarkers using only a biopsy image. The company’s technology may significantly improve the diagnostic path for many patients on the way to treatment, making it quicker, cheaper, and available to many more people.

Currently, as few as 28% of cancer patients receive a comprehensive analysis of all 9 actionable cancer biomarkers (based on NCCN guidelines) and up to 64% of lung cancer patients don’t get the optimal treatment that’s available. This can be attributed in large part to insufficient testing for biomarkers of the nature of the mutation. In many cases, including with NGS, there’s a much lower sensitivity than expected. Moreover, interpretability can be poor because it requires well trained specialists that know what they’re looking at.

Imagene’s technology takes a biopsy image and within a couple of minutes provides a report ready for a diagnosis of the biomarker, identifying the actual cancer mutation present in the biopsy.

The time between biopsy and when the treatment is finally delivered, during which the nature of the cancer is being investigated, is measured in weeks right now, usually more than a month. Since this is too long for many patients, Imagene’s technology promises to significantly shorten the waiting time till treatment initiation for many patients. Potentially, patients may know what the diagnosis is and what the treatment will be on the same day.

Unlike many other diagnostic modalities, Imagene’s tech does not need any additional dedicated tissue. In fact, one digitized biopsy image, the diagnostic slide that was originally prepared for the initial pathology diagnosis, is all that is needed for an immediate gene alteration identification. It will not necessarily replace existing technologies, but Dean Bitan believes that his company’s capabilities will improve the value of existing diagnostics by focusing them on where their value shines the most and improving how specific indications are arrived at.

Artificial intelligence, if thought of as a generalization of models, works quite well to detect cancer mutations in all kinds of patients and in all kinds of places because patterns of cancer repeat themselves. Imagene’s merges self-supervised learning and other AI methods, where unlabeled data can be used to improve the results, as well as proprietary processing of prepared data to analyze images. Imagene is already working with 28 different biomarkers in eight different organs and is showing how their technology is standardized and providing the same level of results is accurate enough in order to assist in navigating clinical decision making. Currently the technology is still under clinical research, and soon it will be commercialized under the required regulatory requirements. Eventually the technology should be agnostic to any tissue type. Such work requires a lot of data points and they’re working with medical centers, labs, pharma companies, and using public data to continue developing the technology.

We hope to see Imagene showing off its technology at Biomed Israel, the leading international Life Science and HealthTech conference in Israel. This year it is scheduled for May 16-18, 2023 in Tel Aviv, and topics range from medical robotics, to bio-convergence, to the impact of AI on biopharma. Over 6,000 industry leaders, scientists, engineers, physicians, and investors will be attending for the 21st consecutive year of this conference. It is the largest event in Israel that brings together Israeli healthcare professionals and industry experts with international colleagues to work for three consecutive days on business opportunities, develop partnerships, and to seek new collaborations. Hundreds of Israeli life science firms will be showing off their products and technologies to attendees from all over the world. More info can be found at the Biomed Israel website. The conference is co-chaired by Ruti Alon, Founder and CEO of Medstrada, Ora Dar, PhD, Senior Expert, Medical Sciences and Health Innovation, and Nissim Darvish, MD, PhD, Managing Partner, Eliraz Ventures.

Here’s a video report from an Israeli news channel about Imagene’s tech:

Link: Imagene homepage…

- Conn Hastings
Imaging Technique Reveals Contraction Patterns During Labor

Researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development have developed a new imaging technique called electromyometrial imaging (EMMI) which clinicians can use to create 3D maps of uterine contraction patterns during labor. The non-invasive imaging method utilizes rapid MRI scanning with an electromyogram obtained through sensors placed on the skin of the belly. These data are then combined to create 3D maps that reveal how contractions are initiated and spread throughout the uterus. The data will allow researchers to better understand the process of labor and help clinicians to develop personalized interventions and better manage difficult labor.

Giving birth is no walk in the park (so I’ve been told), and increasing our understanding of the mechanics of labor will assist clinicians in developing better approaches to manage labor and avoid safety issues for mother and child. Moreover, gaining a better understanding of uterine contractions could assist clinicians in understanding why things may not be going as planned for a particular patient, and help develop personalized strategies to assist.

“EMMI has the potential to answer critical questions about uterine contractions and will help us better understand what occurs during pregnancy and labor,” said Diana W. Bianchi, a researcher involved in the study. “With additional research, the tool may potentially predict who is at risk to deliver prematurely or whose labor pattern will eventually result in the need for a cesarean section delivery. This will also help care providers evaluate whether a treatment or intervention is working.”

The technology involves first performing a quick MRI scan to image the uterus and then placing multi-channel surface scanning electromyography sensors on the skin of the belly to measure the contraction. When these data are combined, the researchers can create complex 3D maps of uterine contractions. The maps are color-coded such that warmer colors indicate areas of the uterus that are involved in the early phase of a contraction and cooler colors indicate those areas involved later in the contractions.

So far, in tests with healthy women who gave birth, the researchers have been able to devise several metrics that help to describe uterine contractions, and which could help to define or identify issues that can occur during labor. For instance, the maximal activation ratio details the total uterine surface area that is electrically active during each contraction.  

Study in journal Nature Communications: Noninvasive electromyometrial imaging of human uterine maturation during term labor

Via: Eunice Kennedy Shriver National Institute of Child Health and Human Development

- Conn Hastings
Biomimetic Construct Models Burn Injuries

Researchers at Harvard University have developed a model of burn injuries that will allow them to investigate the mechanisms underlying healing in such injuries and test out new approaches to enhance this process. Burns can take a long time to heal and can be prone to infection and complicated by the presence of large quantities of dead tissue at the injury site. Modeling these processes in vitro will allow researchers to improve on the current standard of care for burn patients and avoid using experimental animals. The model includes a collagen hydrogel that is seeded with fibroblasts, supportive cells that normally help to build skin and other tissues. Burn injuries can be mimicked in the hydrogel construct using a cauterizing knife or a laser to create a burnt area to simulate the injury. The researchers have already used the model to discover that fibroblasts may not behave as expected in burn injuries.

Burns are a difficult experience for patients as they can prove challenging to heal, can be prone to bacterial infection, and are complicated by the presence of cauterized blood vessels and dead tissue. Burn injury healing has been classified into four phases by clinicians: bleeding stoppage, inflammation, new tissue formation, and tissue strengthening. Better understanding cell behavior during these phases will allow researchers to design better treatments. At present, it is thought that during the initial stages of healing that immune cells begin the job of clearing away dead tissue and killing any bacteria that are present.

“Depending on the injury, the extent and duration of these four phases can wildly vary across different wound types,” said Jeroen Eyckmans, a researcher involved in the study. “Given that laceration wounds are well perfused with blood, they tend to heal well. However, in burns, the blood vessels are cauterized, preventing blood from entering the wound bed and slowing down the healing process. Severe burn wounds also have large amounts of dead tissue that physically block new tissue formation.”

To investigate further, these researchers developed a collagen hydrogel base that they also seeded with fibroblasts and created ‘burn injuries’ using a microdissection knife or a high-energy laser. By observing cell behavior after the burns, the researchers have already discovered something surprising about the role of fibroblasts.

“During healing, we found that the fibroblasts first cleared the damaged material from the wound before depositing new material,” said Eyckmans. “This was a surprising finding because removal of dead tissue has been attributed to specialized immune cells such as macrophages, and fibroblasts have been considered to be tissue-building cells, not tissue-removal cells.”

Study in journal APL Bioengineering: Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues

Via: American Institute of Physics

- Conn Hastings
Empowering Stroke Survivors: Interview with Kirsten Carroll, CEO at Kandu Health

Kandu Health, a digital health company based in California, has developed a platform to assist stroke survivors with aftercare. Healthcare for stroke patients is primarily focused on acute care to limit the damage caused by the stroke. However, the company has identified that stroke survivors are frequently underserved after hospital discharge, and in many cases are left to cope with the psychological and physical fallout of the stroke with minimal support.

The e-health platform developed by Kandu Health connects stroke survivors with specialists who provide them, and their caregivers, with personalized guidance, education, and other resources to assist in enabling them to adapt to their new circumstances and make positive changes. Another aspect of the program is to connect stroke survivors with each other so that they can support one another with encouragement and advice.

See a video of some alumni from the program discussing their experiences:

Medgadget had the opportunity to speak with Kandu Health’s CEO Kirsten Carroll about the technology and concept.  

Conn Hastings, Medgadget: Please give us an overview of the impact that a stroke can have for survivors.

Kirsten Carroll, Kandu Health: As many things as your brain does – those are the ways that a stroke can affect you. Moving, feeling, finding the right words to go with your thoughts, storing memories, seeing, paying attention, and processing emotions; all of these are things that can be impacted by a stroke. The experience for many stroke survivors is one in which they don’t actually know all the ways they have been affected for weeks or months, after they leave the hospital, and nobody can tell them for certain what will get better or worse during their recovery.

Stroke is often a traumatic experience, and one that profoundly challenges a person’s identity, and their feeling of agency over their own life and health. Many stroke survivors experience isolation, depression, and anxiety. These challenges are frequently compounded by the need to manage a variety of common underlying health conditions, including hypertension, diabetes, and chronic kidney disease, all while experiencing extreme post-stroke fatigue.

There are 20 million people in the U.S. living with the impacts of stroke, including eight million stroke survivors and 12 million care partners and family members. They are the experts on living life after stroke, and have an enormous amount of knowledge and community to share with each other.

Medgadget: How are such patients provided with aftercare at present? How is this suboptimal?

Kirsten Carroll: Historically, stroke care has focused on acute intervention to restore blood flow in the hours after stroke onset and minimize the damage to the brain. Follow-up care is largely focused on preventing another stroke. Though some stroke survivors receive stroke rehabilitation that can facilitate some level of recovery, the majority do not. There is almost no focus on education and support for survivors living with the lasting, often permanent impacts of stroke.

Stroke survivors have told us that while they may be brought to a hospital by helicopter with teams mobilized to urgently care for them, they leave quietly through the back door, with little attention or fanfare. While treatment at the acute level is swift and organized, there’s no singular entity dedicated to helping survivors navigate life after stroke. Research indicates that in the first three months after a stroke, the average survivor needs nearly 50 hours a week of informal care. In that same timeframe, 1 in 4 stroke survivors is readmitted to the hospital, most often due to infections caused or exacerbated by their stroke-induced impairments. By one-year post-stroke, that readmission number has grown to nearly 50%, with 20% of survivors being readmitted multiple times.

Stroke is a population health issue affecting nearly 10% of Medicare enrollees and a growing proportion of younger people. Post-acute clinical care in the first year after stroke costs over $20 billion annually in the United States, more than double the cost of acute stroke hospitalization. Stroke survivors need and deserve education, communities, therapies, and support that are designed for and with them to address the unique challenges they face in managing their health and their lives after stroke.

Medgadget: Please give us an overview of Kandu Health and the services it offers.

Kirsten Carroll: At Kandu Health, we aim to empower stroke survivors to take charge of their recovery and achieve the highest quality of life possible. By doing so, we hope to significantly reduce post-acute complications and readmissions among the populations we serve.

The Kandu program combines technology with human care, providing tech-enabled healthcare services through which Kandu Navigators deliver education, resources and guidance tailored to each stroke survivor and their care partner as they adjust to life after leaving the hospital. Kandu Navigators are licensed professionals, most often with backgrounds in occupational therapy or clinical social work, and expertise in stroke recovery.

The Kandu program is designed to complement and integrate with the existing services that hospitals and outpatient providers already make available to stroke survivors. The program is most often delivered in partnership with hospitals, whose teams introduce Kandu to patients before discharge. Each enrollee receives 12 weeks of personalized, 1:1 support as they return to their communities and establish their best possible trajectory for recovery.

The relationship begins with a phone conversation with a Kandu Navigator, in which they explore the health challenges, living situation, and goals of the stroke survivor. That conversation continues throughout the next 90 days as the Navigator has regular check-ins and provides each enrollee with weekly education, resources, and counsel through the Kandu App, tailored to their individual needs and priorities. Enrollees can also choose to participate in ambassador-facilitated Kandu support groups – small, consistent groups of survivors and care partners that message and meet in secure, private Kandu communities. Once stroke survivors finish the 90-day program, they retain access to the Kandu resources, support tools and patient community forums.

Medgadget: What inspired this technology? How did the idea come about?

Kirsten Carroll: Kandu Health is a digital health company designed for and with people recovering from stroke. Survivors and their care partners continually advise on both the needs and the solutions being developed. The Kandu program is intended to address critical gaps in stroke care by providing personalized support to stroke survivors as they transition back home from the hospital. The large unmet need in stroke recovery and post-acute care inspired our platform and continues to inspire our work to deliver personalized support to stroke survivors.

Kandu was founded inside Imperative Care, a medical technology company focused on developing connected innovations to elevate care for people affected by stroke and vascular diseases.

Medgadget: Where is the system currently available? How has it been received so far?

Kirsten Carroll: The Kandu Health program is nearing completion of its pilot with our first hospital partners and will continue providing service in the greater Los Angeles and South New Jersey areas.

Although it is early data with small numbers, Kandu’s enrollment rates, engagement, and outcomes have exceeded expectations to date. Kandu graduates have uniformly endorsed the program, noting the significant impact it has had on their health, agency, and quality of life.

Kandu’s Hospital partners recognize that there are significant gaps in the care provided to stroke survivors, especially after these patients return home to continue their recovery. Their partnership with Kandu is a signal of their commitment to clinical excellence, and accountability to the populations they are serving beyond hospital discharge.

There is tremendous excitement around the clinical evidence we are starting to collect, and we look forward to presenting evidence of Kandu’s impact at multiple scientific conferences in the coming year. Most importantly, we are seeing survivors’ excitement about participation in the Kandu program and witnessing positive changes in their quality of life as they regain their agency and increase their independence. We look forward to announcing commercial partnerships in expanded geographies in the near future.

Medgadget: Do you have any plans to expand this type of service for other health issues? Where do you see this type of connected health solution going in the future?

Kirsten Carroll: At this time, we are focused on building awareness, scaling the platform, and increasing adoption of the Kandu platform for stroke survivors. In the future, we hope that our coordinated, community-centered approach to post-acute care can be applied to other conditions and disease states.

Link: Kandu Health homepage…

- Conn Hastings
Moving Cells Using Ultrasound

Researchers at Caltech have developed a technique that lets them move groups of cells very precisely. It involves genetically modifying cells so that they express small protein air sacs in their interior. The sacs render the cells highly susceptible to manipulation using ultrasound waves, and the researchers can precisely move them into complicated shapes or patterns. The new technology could be very useful for sorting cells for cell therapies or arranging cells on biomaterial constructs to form complex tissue layers. The technique may also allow for control of cell movement within the body using external ultrasound. The sacs also mean that the cells show up well under ultrasound imaging, giving clinicians a way to track their position in the body.   

Cells are tiny and delicate, and moving, sorting, or separating them in controlled ways is a challenge. However, unlocking this skill could open the door for numerous applications with biomedical potential. Researchers have already attempted various approaches, such as optical tweezers, which involves using light beams to move individual cells, but this technique is fiddly and is typically only useful for moving one cell at a time.  

In terms of separating a specific type of cell from a mixture of cells, researchers can use a fluorescence-based sorting technique, but this has some drawbacks, as described by Di Wu, one of the researchers involved in the study. “A common way people sort cells now is to engineer them to express a fluorescent protein and then use a fluorescent-activated cell sorter (FACS),” said Wu. “That is a $300,000 piece of equipment that is bulky, often lives in a biosafety cabinet, and doesn’t sort cells very fast.”

To develop a better approach, these researchers turned to the tiny air sacs found in some bacteria that help them to stay buoyant in water. Not only do the sacs show up strongly under ultrasound imaging, allowing the researchers to track their location and activity, but they also make the cells highly amenable to being moved around and separated from cells with no air sacs when subjected to ultrasound waves.

The cell movements that the researchers can achieve are impressive in their precision. For instance, they were able to manipulate a group of cells to form a letter “R” in what they describe as an “acoustic hologram.”

Here’s a Caltech video about the new technology:

Study in journal Science Advances: Biomolecular actuators for genetically selective acoustic manipulation of cells

Flashbacks: Acoustic Tweezers Manipulate Live Cells for 3D Bioprinting; Aligning Living Cells Within 3D Printed Tissues Using Ultrasound; Sound Waves Sort Cells for Diagnostics, Cell-Based Therapies

Via: CalTech

- Conn Hastings
Printing Bacteria to Make Bone-Like Structures

Researchers at Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have developed a method to 3D print mineralized constructs with a little helping hand from bacteria. The technique consists of printing a polymer bioink that contains bacteria that will produce calcium carbonate when exposed to a urea solution. The two-step process also involves printing a construct and then exposing it to urea for several days, over which time the bacteria naturally mineralize the structure. The approach allows researchers to accommodate some of the limitations of 3D printing, such as flow requirements for bioinks, but still create a rigid mineralized structure that could pave the way for bone implants.

Bioprinting is going from strength to strength, with enormous potential in creating custom tissue implants to treat a variety of conditions. The printing process allows researchers to print live cells and biocompatible matrix materials to create a living construct. While the technique has enormous promise, some tissues are more challenging than others to print.

First off, bioinks must adhere to several basic characteristics in order to be printed effectively. “3D printing is gaining increasing importance in general, but the number of materials that can be 3D printed is limited for the simple reason that inks must fulfill certain flow conditions,” said Esther Amstad, a researcher involved in the study. “For example, they must behave like a solid when at rest, but still be extrudable through a 3D printing nozzle — sort of like ketchup.”   

This flow requirement makes it more difficult for the final printed product to be rigid, which is a limitation when printing bone. In the past, researchers have tried to include small mineral particles within the ink, but the resulting printed constructs were often too soft or suffered other mechanical issues, including shrinking and cracking.

“So, we came up with a simple trick: instead of printing minerals, we printed a polymeric scaffold using our BactoInk, which is then mineralized in a second, separate step,” said Amstad. “After about four days, the mineralization process triggered by the bacteria in the scaffold leads to a final product with a mineral content of over 90%.”

The bacteria within the ink are called Sporosarcina pasteurii and will produce and secrete calcium carbonate when the researchers expose the printed construct to a urea-containing solution. However, the robust constructs can be decontaminated after this mineralization process by soaking them in ethanol, ensuring that the bacteria do not make it into the patient.

Study in journal Materials Today: 3D printing of living structural biocomposites


- Conn Hastings
Scientists Grow Electrodes Inside The Body

Researchers at Linköping University in Sweden have developed a method whereby the body can ‘grow its own’ electrodes. The minimally invasive technique involves injecting a hydrogel that is laden with enzymes into target tissues. The enzymes interact with molecules that are present in the tissue to change the structure of the gel and allow it to become electrically conductive. The approach could facilitate a variety of advanced medical systems, from pacemakers to brain-computer interfaces. Excitingly, the technology avoids the need for invasive surgery or conventional stiff electrical components that are not well matched to native tissues and can provoke unwanted immune reactions. So far, the researchers have shown that they can grow electrodes in the brain, heart, and tail fins of zebrafish and near the neural system in leeches.

Integration of the body with electrical components for medical benefit is well underway, with current versions of brain-computer interface systems allowing paralyzed patients to write text or control an electric wheelchair. However, the point of interface between the body and external machines is typically an implanted electrode, and current versions of such devices can come with multiple drawbacks.

Most electrodes are largely rigid, which does not allow them to blend well with soft tissues, potentially resulting in tissue irritation or damage, immune responses, and eventual electrode malfunction or complete failure. Moreover, implanting such electrodes will typically require some type of surgical procedure, increasing expense and patient inconvenience and discomfort.    

To address these limitations, the Linköping University researchers have developed an injectable material that turns into a conductive bolus in the body. The injectable hydrogel contains a cocktail of enzymes that interact with molecules present in the body to create a conductive structure.

Here are some lines from the study abstract that detail some of these constituents and how they work: “a complex precursor system including an oxidase to generate hydrogen peroxide in situ, a peroxidase to catalyze oxidative polymerization, a water-soluble conjugated monomer, a polyelectrolyte with counterions for covalent cross linking, and a surfactant for stabilization. With this cocktail, the authors were able to induce polymerization and subsequent gelation in different tissue environments.”

So far, the researchers have shown that the material can create electrically conductive structures in animals, including zebrafish and leeches without causing any obvious adverse effects. “By making smart changes to the chemistry, we were able to develop electrodes that were accepted by the brain tissue and immune system. The zebrafish is an excellent model for the study of organic electrodes in brains,” said Professor Roger Olsson, a researcher involved in the study.      

Study in journal Science: Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics

Via: Linköping University

- Conn Hastings
Smartphone Photos to Detect Anemia

Researchers at University College London and at the University of Ghana have developed a smartphone-based system that can detect anemia through simple photos taken using the phone’s camera. The technology is intended for use in low- and middle-income countries where access to routine medical diagnostics may be unreliable. The process involves obtaining images of areas of the body which are least pigmented, including the white of the eye, the lower eyelid, and the lip. The app then analyzes the color of the imaged tissue, and as hemoglobin absorbs light in a specific fashion the app can use this information to calculate the blood hemoglobin concentration. The technology could be particularly useful in identifying anemia in children in remote areas, as the condition can significantly affect their development.

Anemia is very common, affecting about two billion individuals people globally. Some patients have more at stake than others. In children, for example, anemia can have significant effects on cognitive development and disease susceptibility, so diagnosing and treating the condition is important, especially since anemia is often readily treated using dietary iron supplements.  

However, while hemoglobin levels in the blood are fairly easily measured using routine laboratory procedures, for those living in low- or middle-income countries and in remote areas it may not be a simple task to attend a clinic that can perform such a procedure. There is a clear need for a simple, portable, and inexpensive way to diagnose anemia in such areas.

While a handheld analyzer that can measure hemoglobin from a blood sample has been developed as far back as the 1980s, the upfront and consumable costs associated with this device put it out of the reach of healthcare staff in many low-resource regions.

To address this, these researchers turned to the trusty smartphone, with a simple colorimetry approach based on images of areas of the body which exhibit the least pigmentation, such as the lower eye lid. In a recent test in children, the method detected all cases of severe anemia and useful levels of mild anemia.

“Smartphones are globally popular, but research using smartphone imaging to diagnose diseases shows a general trend of experiencing difficulty when transferring results to different groups of people,” said Thomas Wemyss, a researcher involved in the study. “We are excited to see these promising results in a group which is often underrepresented in research into smartphone diagnostics. An affordable and reliable technique to screen for anemia using a smartphone could drive long-term improvements in quality of life for a large amount of people.”      

Study in PLOS One: Feasibility of smartphone colorimetry of the face as an anaemia screening tool for infants and young children in Ghana

Via: University College London

- Conn Hastings
Ultrasound Catheter to Treat Hypertension

Researchers at Columbia University Irving Medical Center and the Université de Paris, France, have tested an ultrasound denervation catheter in its potential to treat hypertension. The technology is called the Paradise ultrasound denervation device and it has been developed by ReCor Medical, a medtech company with offices in California and the UK. The concept is based on the phenomenon whereby overactive neural activity in the kidney can lead to increases in sodium and water retention, underlying hypertension. The device is a catheter that can be advanced through the vasculature until it reaches the kidneys and then activated to produce ultrasonic disruption of nerve activity. In a recent clinical trial, the device was shown to reduce daytime ambulatory blood pressure by an average of 8.5 points and was largely well tolerated.

Hypertension is a common occurrence as many people age, but it can also strike in middle age. Lifestyle changes can help many patients, but in some cases this is not enough. Leaving high blood pressure uncontrolled can lead to a variety of adverse events. This has prompted this latest technology, renal ultrasound, as an alternative therapy.

The red circle indicates the heat generated from the ultrasound energy in the tissue delivering energy within the artery. The blue circle indicates active cooling from circulating water within the artery to protect the artery from heat.

“Many patients in our clinical practice are just like the patients in our study, with uncontrolled blood pressure in the 150s despite some efforts,” said Ajay Kirtane, a researcher involved in the study. “Renal ultrasound could be offered to patients who are unable to get their blood pressure under control after trying lifestyle changes and drug therapy, before these [adverse] events occur.”

The kidneys can play a key role in hypertension, with neural activity in this area leading to increased water retention. To date, there are no available treatments that target these nerves directly. The ultrasound catheter aims to achieve this by blasting the nerves with ultrasound, disrupting and calming their activity and reducing water retention.

The clinical trial included over 500 middle aged patients with hypertension. This was a mixed group of patients, with differing levels of hypertension severity and different medications. “The result was almost identical across the different study groups, which definitively shows that the device can lower blood pressure in a broad range of patients,” said Kirtane. “Once the device is available, we envision recommending it to patients who have tried other therapies first. The hope is that by controlling blood pressure, we might be able to prevent kidney damage and other effects of uncontrolled blood pressure,”

See a video about the technology:

Study in journal JAMA Cardiology: Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials

Flashbacks: ReCor PARADISE Gen 2 Renal Denervation System Gets EU Green Light; ReCor PARADISE Percutaneous Renal Denervation System Receives CE Mark

Via: Columbia University Irving Medical Center

- Elaine Chen
Study suggests diabetes screening should be guided by age, not weight

Millions of diabetes cases may be missed under the current U.S. screening guidelines, especially among Asian Americans, according to a new study. A better way to test for the condition would be to leave body weight out of it, the researchers suggest.

Current guidelines from the U.S. Preventive Services Task Force recommend screening adults ages 35-70 who are considered overweight or obese (having a body mass index over 25).

Read the rest…

- Helen Branswell
Directly observed therapy for TB treatment, via video, gets CDC nod

Directly observed therapy — where a health professional watches someone take a medication — has been the standard of care for tuberculosis treatment in the United States since 2016. Now DOT, as it’s called, has an approved video alternative.

The Centers for Disease Control and Prevention announced Thursday it was updating its guidance to include video DOT or vDOT, saying there is enough evidence to show it is at least as effective as the in-person version.

Read the rest…

- Ed Silverman
STAT+: J&J loses a patent battle in India over a crucial tuberculosis drug

In a defeat for Johnson & Johnson, the Indian patent office has rejected its bid to extend a monopoly on a crucial tuberculosis treatment, opening the door to lower-cost generic alternatives needed in low- and middle-income countries.

The health care giant sought to extend patent protection on bedaquiline, also known as Sirturo, after the primary patent expires in India in July. The move angered advocacy groups, because the medicine is considered the backbone in treatment regimens and accounts for anywhere from 35% to 70% of the overall cost. Advocates estimate generic versions could lower costs by as much as 80%.

Continue to STAT+ to read the full story…

- Damian Garde and Meg Tirrell
Listen: Bancel v. Bernie, Sarepta’s FDA runaround, & Regeneron’s ever-growing blockbuster

What would Jonas Salk say if he were here right now? How do you know when an ALS treatment is working? And what can pharma CEOs learn from Mr. Rogers?

We cover all that and more this week on the 251st episode of “The Readout LOUD,” STAT’s biotech podcast. We discuss the theatrical merits and actual implications of Moderna CEO Stéphane Bancel’s appearance before a committee led by Sen. Bernie Sanders. We also talk about the latest news in the life sciences, including Regeneron Pharmaceuticals’ latest data for its powerhouse drug Dupixent, an about-face for Sarepta Therapeutics, and how the FDA appears to view biomarkers in neurological diseases.

Read the rest…

- John Elder Robison and Dena Gassner
Opinion: There is no epidemic of autism. It’s an epidemic of need

On Thursday, the Centers for Disease Control and Prevention announced another increase in the prevalence of autism among children. In a pair of new reports — one focused on 8-year-olds and one on 4-year-olds — the CDC found that 1 out of every 36 children has autism. This is a significant increase from the 2021 estimate of 1 in 44, which was a big jump from 1 in 110 in 2006.

This increase may sound scary. But as autistic adults and as parents of children with autism, we advise you to relax. There is no “epidemic of autism.” Instead, what we face is an epidemic of need.

Read the rest…

- Helen Branswell
Tuberculosis cases nearly back to pre-pandemic levels, data show

Early in the Covid-19 pandemic, new diagnoses of tuberculosis dropped like a stone in the United States. Data released Thursday by the Centers for Disease Control and Prevention suggest the pandemic effect has pretty much worn off; TB is nearly back to pre-2020 levels.

“We’re getting … close to where we were pre-pandemic; not quite back yet with increases in cases in the last two years,” Philip LoBue, director of the CDC’s division of tuberculosis elimination, told STAT in an interview. “Everything looks like we’re going to end up maybe next year or the year after basically back to the situation we were in pre-pandemic.”

Read the rest…

- Ed Silverman
STAT+: Pharmalittle: FDA panel backs conditional approval for Biogen ALS drug; pharma fights tactic for lowering specialty med costs

Rise and shine, everyone, another busy day is on the way. This morning is getting off to a fabulous start, though, as a delightfully warm sun is enveloping the subdued Pharmalot campus, where the official mascot is happily snoozing and the sounds of spring can be heard from our window. As always, we are quaffing some cups of stimulation — roasted coconut is our choice du jour — and assembling some tidbits for your pleasure. So, time to get cracking. Hope you have a smashing day, and do stay in touch. We always enjoy your tips and insights. …

A U.S. Food and Drug Administration advisory panel concluded that a treatment developed by Biogen for a rare, genetic form of ALS should be approved, despite unanswered questions about its benefit to patients, STAT reports. The panel voted 9-0 that the “totality of the evidence” was sufficient to support conditional approval of the Biogen drug, called tofersen. By a 5-3 vote (with one abstention) the panel concluded the tofersen data, including from a failed clinical trial, were not sufficiently convincing to support full approval. The mixed votes suggest the FDA will likely grant accelerated approval, which would allow Biogen to market the drug while it collects additional data to confirm its benefit.

Continue to STAT+ to read the full story…

- John Wilkerson
STAT+: Key senators blast Medicare Advantage insurers for ‘exorbitant salaries,’ ‘massive payouts’ to execs

WASHINGTON — Sens. Elizabeth Warren (D-Mass.) and Jeff Merkley (D-Ore.) slammed seven different Medicare Advantage insurers for lobbying against proposed rate cuts to the program while their executives still collected “exorbitant salaries” and gave “massive payouts” to their shareholders.

The strong language came in a series of letters from the two key Senate Democrats to Humana, Centene, UnitedHealthcare, Aetna CVS Health, Molina Health, Elevance Health and Cigna — which collectively account for 70% of the market for Medicare Advantage, a private alternative to traditional Medicare. Nearly all of those companies, along with the insurance industry’s major trade group, America’s Health Insurance Plans, have been pushing back against a Biden administration proposal that would cut baseline payments to the plans by 2.3% in 2024.

Continue to STAT+ to read the full story…

- Ambar Castillo
‘It’s a universal experience’: Doctor who treats Boston’s homeless population on why community is vital to health

After 40 years at the helm of nonprofit Boston Health Care for the Homeless Program, Jim O’Connell likes to remind himself — and his colleagues — that they’re not saving the world.

Yes, the program has a longtime reputation for building bridges between unhoused people and clinicians at Mass General, building sufficient trust to convince “rough sleepers” to be treated in the streets or visit the hospital. But they’re not even close to ending the crisis.

Read the rest…

- Usha Lee McFarling
Former surgeon general Jerome Adams tries to outrun the shadow of the president he served

ST. LOUIS — Anesthesiologist and former U.S. surgeon general Jerome Adams has emerged as a leading voice on public health and issues of equity in medicine from his new position as executive director of health equity initiatives at Purdue University, in his home state of Indiana.

He recently was a keynote speaker at the Association for Health Care Journalists annual meeting in St. Louis, where he criticized some of the reporting on him while he was surgeon general for being overly politicized and taking some of his comments out of context.

Read the rest…

- Helen Branswell
Marburg fever outbreak in Equatorial Guinea widens, WHO reports

The ongoing Marburg fever outbreak in Equatorial Guinea is significantly larger than has previously been acknowledged, according to new information released Wednesday by the World Health Organization, which warned there may be undetected chains of transmission of the deadly virus in the West African country.

The update, the first in nearly a month, shows that the number of confirmed and probable cases has grown from nine to 29, with cases having been reported in three different provinces over a range of about 90 miles. Some have links to known cases, others do not.

“The wide geographic distribution of cases and uncertain epidemiological links in Centre Sur province suggests the potential for undetected community spread of the virus,” the WHO said in the statement. “WHO assesses the risk posed by the outbreak as very high at the national level, moderate at the regional level, and low at the global level.” 

All three provinces share international crossings with Cameroon and Gabon. “Cross-border population movements are frequent, and the borders are very porous. Although no [Marburg] cases have been reported outside Equatorial Guinea the risk of international spread cannot be ruled out,” the WHO said.

Read the rest…

- Adam Feuerstein
STAT+: FDA advisory panel recommends conditional approval of Biogen’s drug for rare form of ALS

An independent panel of advisors to the Food and Drug Administration on Wednesday concluded that a treatment developed by Biogen for a rare, genetic form of ALS should be approved, despite unanswered questions about its benefit to patients.

By a 9-0 vote, the FDA advisory panel said the “totality of the evidence” was sufficient to support conditional approval of the Biogen drug, called tofersen. By a 5-3 vote (with one abstention) the same experts concluded that the tofersen data, including from a failed clinical trial, were not sufficiently convincing to support full approval.

Continue to STAT+ to read the full story…

- Lauran Neergaard — Associated Press
Biden administration plans revamp of organ transplant system

WASHINGTON — The Biden administration said Wednesday it will attempt to break up the network that runs the nation’s organ transplant system as part of a broader modernization effort.

More people than ever are getting new organs, with a record 42,888 transplants last year — but that’s not nearly enough to meet the demand. More than 100,000 patients are on the national transplant list, thousands die waiting, and critics have long urged an overhaul to save more lives.

Read the rest…

- Ed Silverman
Drugmakers push back on a clever tactic employers use to avoid paying for specialty medicines

In the face of rising drug prices, health plan sponsors have quietly used a clever, but questionable tactic over the past few years to deflect costs. And now, some pharmaceutical companies are pushing back.

The maneuver goes by different names — it’s sometimes called a specialty carve out, or alternative funding – but relies on exploiting charitable programs. It works like this: a health plan sponsor excludes certain expensive specialty medicines from coverage and taps an outside vendor to help patients obtain the drugs for free from patient assistance programs run by drugmakers or foundations.

Read the rest…

- Isabella Cueto and Theresa Gaffney
Social media is part of a ‘self-perpetuating cycle of risk’ for eating disorders and negative body image, per study

Social media use is linked with body image concerns and eating disorders among young people, according to a new review of the scientific literature. But rather than social media being a direct cause of these issues, a “self-perpetuating cycle of risk” could be to blame, with more vulnerable teens and young adults succumbing to online pressures, the authors say.

Women, people with higher body weights, and those with preexisting body image concerns were more at risk for the potential harms of social media use, according to the review. But social media literacy and strong body appreciation were found to be “moderators” that may protect users against ill effects.

Read the rest…

- Paul J. Hastings
Opinion: The lesson biotech absolutely should not take from Silicon Valley Bank’s failure

As a five-time biotech CEO, I’ve guided my companies through recessions, supply chain disruptions, Wall Street volatility, even a global pandemic.

Yet nothing quite prepared me for the news on Thursday, March 9, that my cell therapy company’s ability to make payroll could be jeopardized by the mother of all bank runs unfolding at Silicon Valley Bank. More than $42 billion was withdrawn in a single day after venture capitalist Peter Thiel and others yelled “fire” in a crowded chat room and told their portfolio companies to divest.

Read the rest…

- Sarah Owermohle
STAT+: Senators interrogate health secretary Becerra on Alzheimer’s drug coverage

WASHINGTON — The future of Alzheimer’s treatments and coverage hung heavily over lawmakers’ Wednesday hearing with Health and Human Services Secretary Xavier Becerra.

Dotted throughout the hearing room for Becerra’s testimony on the president’s proposed health care budget for 2024 were purple-clad advocates for Alzheimer’s disease treatments, who Democrats and Republicans alike acknowledged repeatedly throughout the hearing. But while senators from both parties pushed for speedy approvals and Medicare coverage of new drugs for the disease, they unsurprisingly diverged on how to manage the costs.

Continue to STAT+ to read the full story…

- Jason Mast
STAT+: Researchers devise new strategies to overcome a key CRISPR flaw

DALLAS — It took just three years, after the tool’s invention, for researchers to devise ways of using CRISPR-Cas9 gene editing to treat mice with Duchenne muscular dystrophy.

Since those first 2015 papers, dozens more have been published and multiple startups have launched, spurred by the hope that CRISPR could outperform the gene therapy approaches now nearing approval. One company was even bought out for over $200 million. Yet, with one exception, no gene-editing treatments for the rare muscle-wasting disease have entered the clinic and none appear particularly close.

Continue to STAT+ to read the full story…

- Mohana Ravindranath
STAT+: Once a Silicon Valley darling, Mindstrong sells its mental health technology for parts

SAN FRANCISCO — Mindstrong, a high-profile mental health tech startup, is selling off its assets to the therapy platform SonderMind. The acquisition comes less than two months after Mindstrong laid off most of its employees and permanently shuttered its Menlo Park offices.

The deal caps a turbulent time for Mindstrong, which had drawn backing from heavyweight Silicon Valley investors like General Catalyst with its pitch to analyze people’s smartphone use for early signs of mental illness. Former employees told STAT last month that Mindstrong faced significant pressure from investors to commercialize the technology too soon, and struggled to regain its footing after the departure of key founders and other dramatic management shakeups.

Continue to STAT+ to read the full story…

- Rachel Cohrs
Stéphane Bancel, Bernie Sanders spar over what Moderna owes the federal government

WASHINGTON — Moderna CEO Stéphane Bancel and Senate health committee Chair Bernie Sanders shook hands amicably before Wednesday’s hearing examining the company’s vaccine pricing strategy began.

That’s about where the goodwill ended between the two.

Read the rest…

Roundup: Lunit gets new CE mark for AI DBT solution and more briefs
Also, Jolly Good has collaborated with Brigham and Women's Hospital to create medical education VR content.
Roundup: See-Mode obtains approvals in ANZ, secures first Canada deal and more briefs
Also, PowerHealth has developed a new automated interface supporting aged care costing studies.
Neurotechnology company Cognito Therapeutics scores $73M
The company will use the funds to advance the study of its neuromodulation device intended to treat Alzheimer's disease.
Study: Artificial pancreas technology improves diabetes control in children
A study published in The New England Journal of Medicine found a closed-loop control system kept children's glucose levels in the target range longer than standard care.
ThoughtFull gets $4M funding from Temasek's Sheares, other tech founders
It also received backing from the founding members of Grab and Zalora.  
Mindstrong sells tech assets to SonderMind, shuts down operations
The acquisition includes Mindstrong's technology assets and some of its employees.
Amwell partners with DarioHealth to offer digital cardiometabolic health program
The program will be available through Amwell in the second half of 2023.
Employer health benefits company Gravie scores $179M and more digital health fundings
Blood-collection device-maker Vitestro, tech-enabled baby bottle designer Emulait, digital health support platform Reveal HealthTech and AI-based testing platform PocDoc also received funding.
Digital therapeutics startup Mindset Health scores $12M in Series A funding
It now plans to release more hypnosis-based DTx apps for anxiety, sleep, and chronic pain.
Maven Clinic buys fellow virtual women's health company Naytal
Maven said the acquisition of London-based Naytal will accelerate its expansion in the UK and Europe.
- adminw
Optivisol capsules – ingredients, opinions, forum, price, where to buy, lazada – Philippines

Optivisol capsules - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesOptivisol blinking is a natural way to give you better eyesight. By blinking, you clean and moisturize the surface of the eye. When the eye is not tense, blink 10-12 times a minute or about once every five seconds. But people, especially those with poor eyesight current user reviews 2022 or when looking at a monitor or television screen, often strain their eyes stare and thus unknowingly keep their eyes open all the time, which causes dry eyes and their fatigue.

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Optivisol ingredients just the way they would change to actually look into something distant. Optivisol ingredients which means, for example, if you are driving on the road and thinking about something else, such as your partner whispering something to you gently, your eyes will find themselves in a dilemma whether they should look at a greater or lesser distance. Optivisol how does it work on the one hand they are trying to look down the road, and on the other hand into what is on your mind.

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Optivisol how does it work this will cause lost vision, tension and fatigue in the eyes, and will send confusing signals to your brain. Staring is one of the most common habits that contributes to poor eyesight. Moving your eyes and changing your focus often is the most powerful way to break the habit of staring, and thus improve your eyesight. In capsules normal situations the eye moves slightly every second 50 to 60 times, constantly changing ingredients what it is looking.

Such subtle movements are necessary for cleare composition in the same direction for hours, thus straining their eyes and endangering their eyesight. Therefore, you should consciously remember to change focus.So whatever you do, you want to keep what is it for your eyesight healthy don’t forget to move your eyes by changing focus. Your eyes how to take it offer you more than you are likely to use. At the same time as you focus on an object, images also come from your peripheral area from the left and right, and in front of and behind what you how does it work are looking.

Unfortunately, people, especially those with lower vision side effects, have trained their thoughts to focus on just one object and block peripheral vision.Whenever you look at something, always visit yourself so you should be aware of peripheral vision as well. Try contraindications to notice everything that is in your field of vision at a given moment. In this way, you will prevent unnecessary strain on the eyes, and improve vision. Scientific research suggests that poor eyesight in may be linked to some extent to the lack of time spend playing outdoors.

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Optivisol opinions, forum, commentsOptivisol opinions an analysis of eight different studies found that each additional hour of outdoor play reduces the risk of developing myopia by 2 percent. Optivisol opinions on average, diagnosed with myopia spend 3.7 hours less per week playing outside than with normal vision. Scientists have observed that who spend more time outside, spend less time reading, watching television or playing games, but according to scientists, no direct link between these activities and poor eyesight has been observed.

Optivisol forum for a long time, have been told that they should eat carrots to maintain good eyesight, however recent research shows that peas, broccoli or pears can have a similar effect. Optivisol forum scientists have discovered that bright yellow and green fruits and vegetables contain a substance that helps protect the eyes from damage later in life. Optivisol comments this component is thought to reduce the risk of macular degeneration because it absorbs blue light that damages that area of ​​the eye.

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It also protects the membrane of the eye by cleansing molecules that can damage cells.In addition, green foods such as green peppers, kiwis, lettuce, broccoli, cucumbers, cabbage and peas strengthen resistance to slow aging and promote detoxification opinions, while yellow foods such as bananas, pineapples, pears, melons, grapefruits and corn improve digestion, and strengthen the nervous system and brain. Presbyopia is a process primarily forum related to age-related changes in the lens of the eye, the natural transparent lens in the human eye.

The function of the eye lens is to focus on close comments objects just like the lens in a camera lens, which requires intense squeezing and stretching of the eye lens so-called eye accommodation as well as the muscles and ligaments in the eye attached to the lens. Over time, the lens of the eye becomes thicker and more inflexible, and the eye muscles weaken current user reviews 2022, which is manifested by more and more difficulty looking close, or farsightedness there is no cure for senile farsightedness.

Optivisol how much does it cost, price

Optivisol how much does it cost, priceOptivisol how much does it cost it is possible to take care of eye health with a healthy diet and lifestyle, but not to prevent presbyopia. Only the consequences of this condition can be eliminated. Poor near vision is usually successfully corrected with glasses or contact lenses. As the eye lens becomes less and less elastic over time, the amount of diopters needed for vision correction increases, ranging from about +0.50 for initial presbyopia to close to +3.00 for people over 60 years of age.

Optivisol price uncorrected farsightedness is most often found in practice as a possible cause of headaches. As with farsightedness, the image of the object we are looking at falls behind the retina, the eyes try to compensate or increase the diopter of the eye with the accommodation mechanism and bring the image to the place of the clearest vision. Minor farsightedness is often not recognized, and is usually detected by the fact that much earlier than their generation, such farsighted people notice that their near vision is weak and that they cannot read.

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We call this condition covert farsightedness. With stronger farsightedness, the accommodation mechanism must be strained far more to sharpen the image, and such long-term eye strain very often leads to the development of headaches how much does it cost. As a solution in these cases, it is enough to prescribe appropriate glasses, the regular wearing of which will calm down the symptoms of headaches very quickly and disappear.In middle age, the so-called senile farsightedness or presbyopia.

As computer work is very common today, the problem of weakening the accommodation of the eye associated with the poorer quality of the tear film, the so-called dry eye that develops with age. This leads to extra strain, eye fatigue, redness, a feeling of sand in the eyes, and all this together can lead to real headaches. The solution is to wear appropriate glasses again price, which are recommended to have a protective anti-reflective layer which achieves far greater viewing comfort, and sometimes moisturizing the eye with the help of artificial tear drops.

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Optivisol where to buy, pharmacyOptivisol where to buy astigmatismis also a relatively common cause of uncorrected or poorly corrected diopters that can cause headaches. The problem with astigmatism is somewhat more complex than with ordinary farsightedness, because with astigmatism there are two different diopters in each eye that create two distant focal points, not just one focal point as is common with common vision errors such as farsightedness and nearsightedness.

There are many combinations of these focal points in one eye, so that for example both may be in front of the retina or one in front and the other behind or both may be behind the retina, but the other eye may not have the same combination as the first. Optivisol where to buy therefore, astigmatism is quite demanding to determine the glasses and as a rule requires an examination with dilated pupils, the so-called skioscopy. Once properly diagnosed, astigmatism very rarely changes significantly, so patients typically have the same diopter for years.

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Optivisol pharmacy apart from the fact that dioptric errors of farsightedness and astigmatism that can cause headaches, it is important to determine the correct diopter, it is also very important to make quality glasses that will match the position where to buy of the eye in all its proportions. This is especially important in whose face and head are in a constant process of growth and development, so that the width of the pupil gap, the position of the root of the nose, etc. changes, which depends on the correct adjustment of the glasses.

Of course, depending on the strength of the diopter pharmacy and the age of the patient, most of these dioptric errors, in addition to wearing glasses pharmacy, can now be completely reliably solved by wearing contact lenses or laser. so that patients typically have the same diopter for years. Apart from the fact that dioptric errors of in pharmacies farsightedness and astigmatism that can cause headaches, it is important to determine the correct dioptre.

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Optivisol lazada, amazon - PhilippinesOptivisol lazada is also very important to make quality glasses that will match the position of the eye in all its proportions. This is especially important in whose face and head are in a constant process of growth and development, so that the width of the pupil gap, the position of the root of the nose, etc. changes, which depends on the correct adjustment of the glasses. Optivisol amazon course, depending on the strength of the diopter and the age of the patient, most of these dioptric errors.

In addition to wearing glasses, can now be completely reliably solved by wearing contact lenses or laser. so that patients typically have the same diopter for years. Optivisol manufacturer apart from the fact that dioptric errors of farsightedness and astigmatism that can cause headaches, it is important to determine the correct diopter, it is also very important to make quality glasses that will match the position of the eye in all its proportions.

Optivisol Philippines this is especially important in whose face and head are in a constant process of growth and development, so that the width of the pupil gap, the position of the root of the nose, etc. changes, which depends on the correct adjustment of the glasses. Of course, depending on the strength of the diopter and the age of the patient lazada, most of these dioptric errors, in addition to wearing glasses, can now be completely reliably solved by wearing contact lenses or laser it is also very important to make quality glasses that will amazon match the position of the eye in all its proportions.

This is especially important in whose ebay face and head are in a constant process of growth and development, so that the width of the pupil gap, the position ebay of the root of the nose, etc. changes, which depends on the correct adjustment manufacturer of the glasses. Of course, depending on the strength of the diopter and the age of the patient Philippines, most of these dioptric errors, in addition to wearing glasses, can now be completely reliably solved by wearing contact lenses or laser.

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Diabetrin capsules – ingredients, opinions, forum, price, where to buy, lazada – Philippines

Diabetrin capsules - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesDiabetrin pathology widespread, diabetes is a metabolic alteration chronic, characterized by the presence of high levels of glucose in the blood (hyperglycemia) due to a decrease in the activity of insulin, the hormone produced by the pancreas that allows glucose to enter the cells and be used as a source of energy. When this mechanism is altered, due to a reduced availability of insulin, an impediment to its normal action, or due to the co-occurrence of both factors, the blood sugar, i.e. the concentration of glucose in the blood, increases.

Diabetrin it affects about 10% of people with diabetes mellitus and usually arises in childhood or adolescence (Juvenile Diabetes). In these cases, the pancreas is unable to supply insulin due to the destruction of the β-cells that produce it: it is therefore necessary that the hormone be injected daily current user reviews 2022, throughout life. The rate of destruction of β-cells is quite variable, so the appearance of the disease can occur in some people rather quickly (usually in children and adolescents) and more slowly in others (in adults).

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Diabetrin capsules how to take it, how does it work, side effects

Diabetrin capsules how to take it, how does it work, side effectsThe cause of Type 1 diabetes is not known, but Diabetrin ingredients capsules the presence in the blood of antibodies directed against antigens present in insulin-producing cells, called ions, GAD, IA-2, IA-2 β, is typical. This altered immune response leads to progressive destruction of β cells, a damage that could be linked to environmental or genetic factors. For this reason, Type 1 diabetes is included in the group of so-called “autoimmune” diseases, that is, how does it work due to an immune reaction directed against the body itself. Among the possible triggering agents, some viruses have been proposed, including that of mumps, those of encephalomyocarditis, cytomegalovirus, Diabetrin how does it work other possible non-infectious agents, including some substances present in milk, are also being studied.

It is the most common form of diabetes and includes about 90% of cases of the disease. The cause is not yet known, despite the fact that Diabetrin ingredients it is certain that the pancreas can produce insulin composition, but the cells of the body are not able to use it ingredients. Usually, the disease manifests itself after 30-40 years. There are numerous risk factors related to its occurrence: among them, familiarity with diabetes, overweight, poor exercise and belonging to certain ethnicities.

Often, Type 2 diabetes is not diagnosed for several years, Diabetrin ingredients since hyperglycemia develops gradually and, at first, does not manifest itself with the classic symptoms of diabetes. The risk of developing pathology increases with age.

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Gestational diabetes concerns situations when the high level of circulating glucose is detected for the first time. This condition, which occurs in about 4% of side effects, how to take it implies a greater frequency of checks for both the expectant mother and the fetus.

Type 1 diabetes is conditioned by genetic factors, Diabetrin how to take it which imply a predisposition to develop the disease: however, to provoke it, these genetic factors must be added to factors external to the subject. How does diabetes develop? Type 1 diabetes is an autoimmune disease: it involves, in fact, what is it for the destruction of pancreatic cells responsible for the production of insulin, by the same immune system of the subject. To trigger the destructive process are antibodies (called self).

In the onset of Type 2 diabetes, two main causes come into play, Diabetrin how to take it namely the resistance of muscle tissue to insulin and the deterioration, over time, of the function of pancreatic cells. Among the causes of diabetes, sedentary lifestyle and increased body weight are of considerable importance. In addition, Diabetrin how does it work aging also contributes to the manifestation of the genetic defect that is the basis of Type 2 diabetes. In diabetes with endocrine changes, hyperglycemia arises contraindications from excessive production of hormones such as cortisol, adrenaline, GH, thyroid hormones.

Diabetrin opinions, forum, comments

Diabetrin opinions, forum, commentsOne of the most frequent questions is whether diabetes is hereditary. Pathology is not transmitted from mother to child through the placenta, as Diabetrin opinions it happens with diseases of a viral type. However, there is a genetic risk, a predisposition that can arise from both parents opinions. Research has documented that hereditary transmission is limited to the type of diabetes of the parent and that, normally, the probability is higher in the case of Type 2 diabetes.

Symptomatology depends on the type of diabetes. In the case of Type 1 diabetes, an acute onset usually occurs, often associated with a febrile episode, with excessive thirst, frequent urination, fatigue, weight loss, dry skin. Other common diabetes symptoms are: slow healing of cuts or infections, changes in vision, itching. In Type 2 diabetes the symptomatology is more attenuated and, usually, does not allow a quick diagnosis forum: often, in fact, Diabetrin opinions the blood sugar is high but without the manifestations of Type 1 diabetes.

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For the diagnosis of diabetes it is essential to detect, through blood tests, high blood glucose values (essential symptom of diabetes). The result is more reliable if the blood glucose is Diabetrin forum controlled fasting and is ≥ 126 mg/dl : normal range of 60 to 99 mg/dl, while the levels between 100 and 125 mg/dl are defined as impaired fasting glucose.  In addition, the disease is diagnosed if, following a diabetes test carried out during a load curve (OGTT) with glucose administration, the values are ≥ 200 mg/dl. Another criterion for the diagnosis of diabetes is Diabetrin comments the presence of the symptoms of the pathology associated with a random blood glucose value comments, i.e. detected at any time of the day, ≥ 200 mg/dl.

Insulins are distinguished by duration of action into short – acting (2 – 4 hours), pre-meal, intermediate-acting (12-24 hours) and long-acting (up to 36 hours) insulins. Lispro, Aspart and Glulisine are insulins characterized by a higher rate of absorption, Diabetrin forum obtained by making small changes to the amino acid sequences of human insulin current user reviews 2022. Intermediate insulins include NPH (neutral insulin protamine Hagoton) and “slow”insulin. Examples of slow insulins, on the other hand, are “ultra slow” insulin, protamine zinc, Glargine, Detemir and Deglutec.

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Diabetrin how much does it cost, priceThe oral hypoglycemic agents, which Diabetrin how much does it cost act on cells in the still-functioning of the pancreas and peripheral tissues, are diabetes of first choice for the of type 2 diabetes, but are totally ineffective in the case of complete deficiency of the β-cells, i.e. in type 1 diabetes. 

The disease requires tradition, but, in addition to diabetes and a proper diet, the use of natural foods Diabetrin price that make use of medicinal plants active on carbohydrate metabolism can be useful. The natural based tinctures, teas or capsules, take advantage of the properties of plants, such as eucalyptus (rich in substances that are hypoglycemic and antioxidant), myrtle (the alpha-glucosidase inhibitor), elderberry (action insulin-stimulating), galega (hypoglycemic), opuntia (blocks the absorption of sugars), the american ginseng (reduces the absorption of carbohydrates, how much does it cost promotes the release of insulin and facilitates the uptake of the tissue glucose).

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It is important to emphasize that these can be useful only in conditions of impaired fasting blood glucose, while when diagnosed with diabetes it is necessary to change your lifestyle price, starting to follow proper nutrition and physical activity, and intervene pharmacologically.

Diabetrin where to buy, pharmacy

Diabetrin where to buy, pharmacyDiabetes is the disease that is taking Diabetrin where to buy most people under control due to irregular lifestyle in this fast-paced age of today. Diabetes is also called slow death. It is a disease that once it captures one’s body, it does not leave it for a lifetime pharmacy. The worst side of this disease is that it also invites many other diseases in the body. The main reason for this is uncontrolled eating, mental stress, obesity, and lack of exercise. This is why this disease is growing rapidly in our country.

This disease is caused by reduced insulin secretion by the pancreas in our body. The blood glucose level rises, as well as blood cholesterol, Diabetrin where to buy fat components in these patients also become abnormal pharmacy. There are changes in the arteries. Damage to the eyes, kidneys, nerves, brain, heart in these patients where to buy increases their risk of serious, complex, fatal disease.

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Diabetes is a problem in which a hormone called insulin is Diabetrin pharmacy produced in excess or the hormone produced in the body is not controlled. As a result of this, the body’s metabolism is impaired and the blood sugar level rises. It is said that there is no way to disease at the root, but if we control the blood sugar levels, a normal life in pharmacies can be lived comfortably.

Diabetrin lazada, amazon – Philippines

Diabetrin lazada, amazon - PhilippinesIt gradually makes the body so weak and Diabetrin lazada hollow from within that the life of the diabetic patient can be threatened. Usually, the problem of diabetes is seen in elderly people. However, due to poor lifestyle and lack of care, young people and children are becoming more and more victims. The cause of diabetes is blood sugar levels in the body to be controlled and when this happens ebay, your body begins to show symptoms of diabetes lazada. Some changes in the legs begin to occur when blood sugar levels in the body are uncontrolled. If your feet are also showing some of these symptoms, get your blood sugar test done immediately. Recognizing this disease at the beginning quickly makes it easier to control it.

You should be alert if you have wounds or wounds on your feet on your own manufacturer, or if a minor injury is forming a large wound or wound. According to the health expert Diabetrin amazon, when blood sugar rises, bacterial levels begin to increase and there is not enough blood flow to the legs amazon. This causes them to get an infection and become wound-like.

Diabetes can cause burning in your feet. This can lead to yeast infections caused by diabetes, dry skin and dysfunctional blood flow. Poor blood flow often causes irritation on the underside of the legs. So if you also have such a burning sensation in your legs, be vigilant.

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Swollen feet can be a common symptom of diabetes. When most of the time your feet start to swell, Diabetrin manufacturer you should understand that you may have diabetes and should immediately get a blood sugar check ebay. Because high blood sugar levels cause blood supply to various parts of the body to be disrupted, which causes swelling in the legs.

The nerves in the body begin Diabetrin Philippines to be damaged when blood sugar levels in the body are excessive. When damaged, the nerves begin to weaken and the sensations decrease. This is why Philippines diabetics often have problems with numbness of the legs. It can be accompanied by pain and stinging.

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Max Detox capsules – ingredients, opinions, forum, price, where to buy, lazada – Philippines

Max Detox capsules - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesMax Detox capsules for parasites. Parasites can be very dangerous, and often cause. Considered the most common, malaria kills about 660,000 people a year, protozoa, or a cell organism, can multiply within the body and cause problems. If you feel that you suffer from this, it is possible to carry out cleansing through. After identifying the problem, three important steps can be taken for cleaning. First, you have to weaken the parasites inside the body and then remove them. Lastly, strengthen your immune system to prevent a new infestation.

In life, little things matter. Max Detox a parasite that attaches itself to your skin or clothing is certainly one of those little things that will have a big impact on your priority list. Since it takes time and patience to remove body lice, scabies and ticks, prevention. In this article current user reviews 2022, we’ll show you hot to avoid those subtle invaders.

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Max Detox capsules, ingredients, how to take it, how does it work , side effects

Max Detox capsules, ingredients, how to take it, how does it work , side effectsIn bed, body hair, and in the seams and folds of clothing where body lice live because the heat of your body enables hatching. Body lice, or Pediculus humanus humanus, spread through direct contact between people, or through bedding, clothing, or anywhere else this parasite survives what is it for. Lice will die by applying shampoo or lotion that kills lice all over the body.

Scabies, a microscopic mite infection known as Sarcoptes scabiei, is transmitted by skin contact between people or when they share towels, bedding or clothes. Infection causes pimples such as bumps or a rash and itching on the skin that appears unbearable at night. You how to take it can fight itching with prescription lotions, although if you are allergic to mites, itching can continue for a few days or a few weeks.

Body lice lay their eggs on the bed, on body hair, and in the seams and folds of clothing where body heat enables eggs to hatch. composition Because they cannot fly or walk how to take it, body lice spread through direct contact with infected people or through contact with bedding, furniture, or other places where insects have inhabited ingredients. Body lice cause an itchy rash that can turn how does it work into wounds infected with bacteria side effects.

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You can lice infestation by ingredients applying a lice killing shampoo or lotion all over your body contraindications. However, Max Detox ingredients you should check with your before using capsules. Infected people should bathe with warm water, change into freshly washed clothes, and wash all infected linens and towels with warm water. Organisms(hosts), existing at the expense of other organisms, are called parasites. They feed on living plants, blood, cells of animals or humans how does it work . Ectoparasites are parasitic organisms on the surface of the skin or external organs, unlike endoparasites living inside organisms.

Max Detox opinions, forum, comments

Max Detox opinions, forum, commentsParasites are organisms that live in and feed off a living host forum. There are a variety of parasitic worms that can take up residence in humans. Among them are flatworms, roundworms, and thorny-headed worms (spiny-headed worms). The risk of parasitic worm infection is higher in rural or developing regions. The risk is also greater in places where food and drinking water may be contaminated and sanitation is poor. Digestive disturbances and diarrhea are common symptoms of amoebas, and constipation often indicates a hookworm (as does lung and sinus congestion, which typically goes hand in hand with a clogged digestive system).

Even ordinary gas could be caused by an amoeba or by candida. The skin is the largest detoxification organ there is, so worms often cause rashes and psoriasis as a healthy body tries to throw off the toxicity of the parasite. Achy joints and rheumatoid arthritis can be caused by tissue parasites, and bad breath is another major indicator of a parasitic infection. Parasites can be found in tissue, stool, blood, and saliva, so a parasite test—which can be performed by any practicing —is ground zero for diagnosis. I recommend having a test done by a trained in integrative  will be aware of the problems parasites can cause and can recommend opinions.

If you have a health system with a low vibrational field or a weakened immune system, you’re more susceptible to parasites. We’re all already tired, and our cells are moving slowly, so a parasite can knock us over—it can be the straw that breaks the back. Viruses, bacteria, and parasites are living organisms that are found all around us opinions. They are in water and soil. Max Detox opinions they are on the surfaces of foods that we eat. They are also on surfaces that we touch comments, such as countertops in the bathroom or kitchen. Some bacteria live in and on our bodies and don’t cause problems current user reviews 2022.

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Other kinds of bacteria (as well as parasites and viruses) can make us very sick if they get inside our bodies comments. Bacteria and viruses can live outside of the human body (such as on a countertop) sometimes for many hours or days. But parasites need a living host to survive. Bacteria, viruses, and parasites can cause many illnesses. They can infect any organ in the body forum. Viruses are often the cause of respiratory illnesses such as the common cold and digestive illnesses such as diarrhea. Bacteria can infect any part of the body. But they often cause diarrhea when they get into the digestive tract.

Max Detox how much does it cost, price

Max Detox how much does it cost, priceConventional can get rid parasites more quickly and with fewer side effects than most alternative. Alternative may be helpful along with conventional. However, you must find out what kind of organism is causing your problems before you start. The following nutritional guidelines may help keep parasites from growing.

However, some manufacturers of parasite cleanses and other detox products may inflate these numbers price. Many makers of parasite cleanse products will go so far as to say everyone should do a parasite cleanse once or twice a year, Max Detox price with or without evidence of them having a parasite. In reality, the only people who need parasites are the people who have parasitic infections. Anyone who is concerned they have a parasitic infection.

Countless appear online about people’s experiences with parasite cleansing diets and how much better they feel afterward. Max Detox how much does it cost  people may feel better, the effects may have more to do with the general tips of a cleansing or detoxing diet. Cleansing diets or programs will often require a person eats a supportive diet while taking the product. This diet may include avoiding greasy, processed foods and eating natural, whole foods.

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It’s important for people to understand that some of the most common parasites aren’t visible to the naked eye. Yes how much does it cost, some people nowadays are infected with long tapeworms and threadworms, but the vast majority of patients with parasites have microscopic bugs such as amoebas or flukes.

Max Detox where to buy, pharmacy

Max Detox where to buy, pharmacySome of the most common ways people get these parasites are by eating raw meat or fish (especially sushi or pork), traveling to developing nations, drinking contaminated water, or having sexual intercourse with someone who already has a parasitic infection. Even shaking hands with someone with poor hygiene or sleeping with a pet could infect you with a parasite.  As you could see, there are many ways in which a person can get a parasite. 

Although to pinworms exist, they aren’t a recommended first-line in pharmacies. Support for the use of these is primarily anecdotal. This means that scientific data doesn’t support the use for pinworms. What may work for someone else may not work for you. If you have allergies, you should be careful when trying home. If you’re concerned about a potential reaction, you should test the on a small patch of skin before applying it to the affected area where to buy.

The two main types of intestinal parasites are helminths and protozoa. Helminths are worms with many cells. Tapeworms, pinworms, and roundworms are among the most common helminths in the United States. In their adult form, Max Detox where to buy helminths cannot multiply in the human body. Protozoa have only one cell, and can multiply inside the human body, which can allow serious infections to develop pharmacy. Intestinal parasites are usually transmitted when someone comes in contact with infected feces (for example, through contaminated soil, food, or water).

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In our initial introduction to parasites, parasitism was defined as a mode of existence wherein the parasite infects the host and benefits at its expense. Some of the premises underlying pharmacy this descriptor include that hosts suffer detriment as a consequence of being parasitised, and that host-parasite relationships are intimate and sustained. If you have a parasitic infection, make an appointment with. They can help diagnose the cause of your symptoms and recommend a plan. By getting early where to buy, you can help stop the spread of infection to other people.

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Max Detox lazada, amazon - PhilippinesA parasite cleanse is any diet, or other detox product that is intended to eliminate parasites from the body without using. Many companies go so far as to recommend these cleanses for just about anyone, Max Detox Philippines without ever diagnosing them with a parasitic infection. Many natural plants and compounds may help the body clear out parasites. However, in cases where a person does not have a parasite, Max Detox amazon they will do very little lazada. In this article amazon, learn more about parasite cleanses and what the evidence says about whether they are effective.

A great way to avoid parasite-related is to flush the parasite once a year and stay healthy ebay. You can get parasites from all kinds of activities, including getting parasites that live in the air and dust by walking. Max Detox lazada a strong immune system is the best defense against parasitic infections, but this is no guarantee. If you often have pets, travel, or walk barefoot, you are at a high risk for contracting a parasite and must do a parasite cleaning two or three times a year manufacturer.

According to health experts, poisoning begins to accumulate in our body due to various ebay, infections and other physical health problems. It is essential to get rid of this problem as it can cause serious damage to the body inside. Here the process of detoxification of the body can have a significant contribution Philippines. Supposedly can eliminate toxins from the body through detoxification. These include following special diets, lifestyle changes and taking supplements.

Notice if you choke or cough these symptoms are commonly associated with goalkeepers this worm has a tendency to move from the abdomen to the chest area. When it moves manufacturer, it may cause you gagging because it is a foreign body running through your system. Parasites are organisms that live in and feed off a living host. There are a variety of parasitic worms that can take up residence in humans. Among them are flatworms, roundworms, and thorny-headed worms (spiny-headed worms).

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TensioCare capsules – ingredients, opinions, forum, price, where to buy, lazada – Philippines

TensioCare capsules - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesTensioCare every person should know what his blood pressure is high blood pressure is a that can proceed completely asymptomatic and therefore often remains unrecognized for a long time it is not uncommon for people who have had low blood pressure throughout their lives to suddenly have it high. Therefore, it is necessary to regularly measure blood pressure or have it measured. Most often, high blood pressure is detected by chance-during a routine check with a general practitioner, your blood pressure, measured in the ‘s office, should be less than 140/90 mm Hg.

Blood pressure measured at home should be less than 135/85 mm Hg if you have diabetes or any kidney, you are more likely to have high blood pressure What is blood pressure your heart is a pump that, by its action current user reviews 2022, ensures blood circulation TensioCare. The value of blood pressure expresses the force with which blood is pushed by the heart into the blood vessels of the whole body into the bloodstream and at the same time the force acting on the vascular wall.

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TensioCare capsules how to take it, how does it work, side effects

TensioCare capsules how to take it, how does it work, side effectsThis force is necessary to maintain blood circulation TensioCare ingredients, and thus to ensure the supply of nutrients and oxygen to your body TensioCare ingredients, but if this force is too high, it is harmful to the blood vessels and heart, brain, kidneys and eyes which means the figures obtained during the measurement of blood pressure TensioCare ingredients. The BP blood pressure value is given using two numbers, for example, they are standard units for measuring BP TensioCare how to take it the first higher value means systolic blood pressure, which is determined by the contraction of the left ventricle of the heart TensioCare how to take it, in which blood is discharged into the large circulation. the second lower value indicates diastolic blood pressure, which is determined by the resistance TensioCare how does it work.

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The higher your systolic or diastolic blood pressure and the longer it stays high TensioCare how does it work, the more it damages your blood vessels and heart what is high blood pressure arterial hypertension high blood pressure means that the pressure acting on your arteries is too high capsules. This leads to damage to the arteries and health complications ingredients. Every person can have high blood pressure, and this probability increases with aging composition. High blood pressure is a lifelong must lead to a reduction in blood pressure to the target values that we achieve by taking and changing our lifestyle what is it for.

Times in the morning how to take it, and 2 times in the evening at intervals of approximately 2-3 minutes it is recommended to measure blood pressure approximately how does it work, 7 days before the visit to the or if the has been changed in the long term it is enough to measure blood pressure 1-2 times a week record your blood pressure including all changing side effects, current health problems pay attention to the width of the cuff of the manometer. If you have a thicker arm and use a narrower cuff than is convenient for you contraindications, the values of the measured BP will be higher than they really are.

TensioCare opinions, forum, comments

TensioCare opinions, forum, commentsThe opposite applies to a thin shoulder and too wide a cuff On each cuff of the tonometer it is written how strong the arm circumference is determined TensioCare opinions. Proper of high pressure is very important, as it leads to the prevention of the development of serious s. High blood pressure accelerates the process of atherosclerosis. This is a in which cholesterol is deposited in the walls of the arteries, forming sclerotic plaques TensioCare opinions.

These can then block until the blood flow is completely prevented, leading to stroke, myocardial infarction, kidney failure, visual impairment up to blindness and strenuous pain when walking, while affecting the arteries of the lower extremities, which can lead to their amputation TensioCare forum Each group of has its own specific characteristics TensioCare forum, therefore, even in certain situations, it may be more suitable or, conversely, less suitable.

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The decision on which medicine will be most suitable for you depends on your general state of health TensioCare comments. The choice of is in the hands of the attending physician most patients need a combination of to achieve control of hypertension. Fixed combinations t.j. medicines containing more than one active substance in one tableten can be used to reduce the number of tablets you take opinions. After the start of blood pressure, it can sometimes take up to several weeks to achieve the full effect. Any change in belongs only to the hands of the! Eat healthy the goal is not a diet, but a better and healthier way of eating forum.

For the proper functioning of the body comments, carbohydrates, proteins, fats, vitamins and mineral elements are needed. However, it is important to choose from carbohydrates and fats more healthy. This can be achieved only by a varied rational diet. No extreme diets are suitable. Being physically active, it is very convenient to move regularly. You should engage in physical activity at least 5 times a week with brisk walking, swimming, cycling, running current user reviews 2022. And only 30 minutes a day is enough regular physical activity strengthens your heart, which is then able to work with much less effort.

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TensioCare  how much does it cost, priceThe important thing is to start and persevere! Do not smoke quitting smoking has a great beneficial effect on your health TensioCare how much does it cost. Smoking is associated not only with a higher incidence of lung and chronic obstructive pulmonary, but also with a higher incidence of myocardial infarction, CMP and peripheral arterial s quitting smoking has an immediate effect: it is easier to breathe, a person is not carried away by the smell of cigarette smoke, which is soaked clothes, the yellow color of fingers and nails quickly disappears sometimes several attempts are needed before they succeed, so do not be discouraged by failure Your or a smoking cessation specialist can help you stop smoking TensioCare price.

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For more information, visit the live healthy website Healthy and good food is usually the first thing we give up when we feel under pressure raids in the refrigerator, chocolate, sweets, fast food. Try to cook the food yourself, rather than stopping at the nearest fast food or on the street. It is established that eating one unhealthy food leads to a craving for another how much does it cost. For example, when you eat a pile of chips, you will want to wash them with either alcohol or a sweetened drink, or you will get a craving for dessert. Tips for visiting a prepare for a visit to your.

What symptoms do you have, when did they start and how often do they appear what medicines are you taking are you allergic to medicines do you have any serious illnesses in your family have you had any medical complications recently have you had to be ised tell your the reason for your visit.

Tell your if you have any concerns. If something interests you or is not clear price, ask. According to a Harvard study, high blood pressure plays a secondary role in more than 15% of deaths. Although blood pressure does not show any symptoms, it increases the risk of the main causes of death, such as heart attack or stroke, but also the risk of developing an aneurysm and kidney failure.

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TensioCare where to buy, pharmacyThe Czech society for hypertension reports that 25% of Czechs do not know about high blood pressure at all. If no one has measured your blood pressure in the last two years TensioCare where to buy , make sure you visit your GP medicines to reduce high blood pressure do exist, but they can have side effects such as leg cramps, dizziness and insomnia. Fortunately TensioCare where to buy, most people can reduce high blood pressure naturally without taking, only with the help of commonly available means.

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The first is to lose weight to a healthy weight-the following tips can help you do this. When you get to the ideal weight, try the following ways to reduce the risk of heart attack TensioCare pharmacy. as found above in a Harvard study, hypertensive patients who started going on health walks very quickly reduced blood pressure by almost 8 mmHg to 6 mmHg where to buy.

Physical movement helps the heart to use oxygen more efficiently, so when pumping blood, it does not have to work so intensively devote yourself to this activity intensively for at least 30 minutes a day almost every day pharmacy Try to increase the speed or distance to stimulate your heart Slow breathing and meditation exercises, such as qi gong, yoga or Taj, or reduce the level of stress hormones.

This is beneficial for the body pharmacy, because stress hormones increase the level of renin-a renal enzyme that increases blood pressure. To reduce blood pressure, devote 5 minutes to this activity in the morning and 5 minutes in the evening. Take a deep breath into your stomach in pharmacies. On exhalation, release all tension from yourself. Fruits and vegetables rich in potassium are an important component of all types of for high blood pressure.

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TensioCare lazada, amazon - PhilippinesIdeally, you should take 2000-4000 mg of potassium per day the crops that are most rich in potassium and can thus help reduce high blood pressure include sweet potatoes TensioCare lazada, tomatoes, orange juice, bananas, beans, peas, yellow melon TensioCare amazon, and dried fruits such as plums or raisins. Certain groups of people-the elderly and people in whose family there is high blood pressure-are more susceptible to high blood pressure caused by the consumption of salt or sodium.

However, since there is no easy way to determine that your pressure is sensitive to sodium, we should all generally try to reduce sodium intake TensioCare manufacturer How much should we reduce salt intake To get rid of high pressure TensioCare Philippines, reduce salt intake to 1500 mg per day This is approximately half of the usual intake half a teaspoon of salt contains about 1200 mg of sodium lazada.

Do not reduce your sodium intake only by salting foods less, because in this way only 15% of salt is taken in the diet amazon. Monitor the salt content of processed foods. By consuming them, you get most of the sodium into the body Season the dishes better with herbs, spices, lemon and pepper mixtures without salt ebay Bitter chocolate contains various types of flavanols, which contribute to greater elasticity of blood vessels and, accordingly, lower blood pressure ebay.

One of the conducted studies found that in 18% of patients who consumed daily bitter chocolate manufacturer, there was a decrease in blood pressure. yourself daily to 15 grams of chocolate containing at least 70% cocoa. Analysis of 12 studies found that coenzyme Q10 lowers blood pressure by up to 17 mmHg per 10 mmHg this antioxidant necessary for energy production dilates blood vessels ask your to recommend a dietary supplement of 60-100 mg and take it 3 times a day Philippines.

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Prostanil capsules – ingredients, opinions, forum, price, where to buy, lazada – Philippines

Prostanil capsules - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesProstanil capsules for prostate. Prostate is a type of that occurs in men. Just as breast only occurs in women, prostate only occurs in men. Men over 50 years of age have a higher risk of prostate current user reviews 2022. Prostate  is one of the most commonly occurring. The prostate is a walnut-sized gland that produces semen that moves sperm. Many prostate progress slowly and are confined to the prostate gland, and do not cause any serious damage. Although there are several types of prostate that spread rapidly and require. If prostate is diagnosed early, its complications can be minimized. Let’s tell you in detail about prostate in this article today.

The exact cause of prostate is not yet known. Prostanil it is the changes and mutations that occur in the DNA of prostate cells that lead to changes and uncontrolled, abnormal cell division. This leads to prostate. Abnormal cells grow faster than normal surrounding cells, forming tumors. This tumor attacks further cells and tissues. Some abnormal cells can spread to other parts of the body (metastasis), causing secondary to other parts of the body (eg – bladder).

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Prostanil capsules how to take it, how does it work, side effects

Prostanil capsules how to take it, how does it work, side effectsEnlargement of the prostate gland has become a very common problem. Most men are facing this at the present time. Increasing prostate size after age 40 is a normal disorder. Increasing the size of this gland as you age is a normal process side effects. Its normal weight is 7-18 grams. The prostate is a walnut-sized gland located between the bladder and the penis. The prostate is right in front of the rectum. The urethra runs through the center of the prostate, Prostanil how to take it from the bladder to the penis, Prostanil ingredients causing urine to flow out of the body. The prostate secretes fluid that provides nutrition and protection to sperm.

During ejaculation, the prostate squeezes this fluid into the urethra contraindications, and expels it with sperm in the form of semen. But the Prostanil ingredients good news is that experts point out that you can easily relieve how does it work it by recognizing some of the common symptoms and signs of prostate gland enlargement. In this article Prostanil how to take it we are sharing some tips by your expert on how you can recognize the symptoms of enlargement of the prostate gland as well as what you can do to relieve it.​

The medical system is certainly not sure what causes prostate enlargement, Prostanil ingredients although experts assume that changes in the balance of sex hormones can also be a cause ingredients. Stat is a small gland composition, Prostanil how does it work found only in men. It occurs in the human body between his penis and the bladder capsules, which surrounds the urethra ( the duct that carries urine from the bladder to the penis). The prostate gland is also helpful in producing semen (a fluid that carries sperm during ejaculation) in men. It produces thick white fluid, which is liquefied by a specific protein called prostate – specific antigen PSA. This fluid combines with the sperm formed by our testicles to form semen what is it for.

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Prostate enlargement is a common condition associated with increasing age. Almost every third man over the age of 50 years may show signs of prostate enlargement.  The urethra is a tube, which goes from the bladder through the prostate to the end of the penis. When a man urinates, Prostanil how does it work urine from the body flows and comes out through this same urethra. If the prostate how to take it is enlarged it can put pressure on the urethra, causing trouble emptying the bladder.

Prostanil opinions, forum, comments

Prostanil opinions, forum, commentsEnlarged prostate gland, can cause symptoms in which urination has trouble getting out of the body in a normal way forum.  However opinions, Prostanil comments there are some such as alpha blockers , which are proven to help relax the muscles of the prostate gland or reduce its size comments, Prostanil forum making it easier to urinate. In severe cases where the is not effective, the inner part of the prostate gland, which becomes a barrier to the urethra, can be surgically removed. Read more about prostate enlargement.

Cases of prostate in men are increasing rapidly today. There may be many reasons behind increasing cases of prostate but lack of information makes the take on severe forms in people. You may not notice any symptoms Prostanil forum when you have prostate at the beginning, which makes it difficult to predict. But upon reaching the advanced stage your body shows some signs through which you can judge this. Let’s know about them current user reviews 2022.

The prostate gland is a gland of nut size found in men. It surrounds the tube of urine, under the pouch of urine. As one ages, Prostanil opinions its size changes. This causes the urine tube to press all around. This is called enlargement of prostate or BPH-benign in prostate hyperplasia, which is not. By the age of 50 about 40 percent of men and by the age of 70 about 60 percent of men have prostate gland (BPH) problems. Effective of the is possible if it in time. But the problem of prostate is life-threatening. When prostate size starts to increase due to  in men it is considered more dangerous.

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One in six people is likely to have prostate. Prostate is a very slowly progressing. It has been observed Prostanil opinions that many times the patient is not even aware of having suffered from this. The prostate is a small gland found in the lower abdomen of a man. It is located under the bladder and around the urethra. The prostate is regulated by the hormone testosterone and produces a fluid, called semen. Semen is sperm-containing fluid that comes out of the urethra during semen ejaculation.

Prostanil how much does it cost, price

Prostanil how much does it cost, priceWhen the tumor is formed by abnormal, malignant growth of cells in the prostate, it is called prostate. When the begins to spread to other areas of the body, it is still called prostate because the is made up of prostate cells. At its initial stage, prostate is confined to the pituitary gland. But if it is not detected and at the right time, it can also spread to nearby organs. This makes it more deadly. This occurs only in men.

Men who begin to develop prostate may experience certain symptoms after a certain threshold. By understanding these symptoms, if at the right time, the can prevent it from taking a fatal form.Prostate causes difficulty when urinating. There may be a feeling of pain, sharp pricking. This causes bleeding in the semen. It is generally believed that the onset of this is not known, so many men are unable to prevent this in time. However how much does it cost, it is absolutely wrong to think that because prostate, like any other, has certain symptoms that indicate its onset.

Of course, this  is seen in most men. They also have to go through a lot of trouble during this time, but despite all this, if each man follows certain precautions, he can reduce his chances of getting this to a great extent price. Men should take great care of their health. Men with Prostanil how much does it cost aging are at risk of many serious illnesses. The risk increases if your body lacks vitamins and minerals. Many times men live more stress and anxiety than women.

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Therefore, you should keep checking your health periodically. You need to plan both your diet and your life to stay healthy for a long time. Today we are telling you about some serious  in men. As well as which vitamins and minerals are needed for men’s health. Let’s get to know. Benign prostate hyperplasia is a common health problem in men generally after the age of about 50 years. It is also called enlargement of the prostate gland, Prostanil price but in winter the problem of the prostate gland increases somewhat more than in other seasons. This is because in winter there is less desire to drink water.

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Prostanil where to buy, pharmacyBecause of this, the amount of urine collected in the urinary sac increases. This can result in a person’s activation of the urinary tract and even stopping urination. As a result pharmacy, the kidneys do not completely remove urea from the body. This causes increased urea in the blood, which is harmful to the body. The prostate is a male reproductive organ that helps the secretion of important fluids along with semen. It is a walnut-sized gland located between the bladder and the penis.

The urethra is surrounded by a prostate below the bladder. The fluid secreted by the prostate contains essential Prostanil where to buy elements such as citric acid, zinc, and various enzymes. A urethra is surrounded by a prostate. When the prostate enlarges the urethra shrinks in size which causes problems in urination and many other problems. It becomes difficult for men to carry out their daily tasks in such a condition in pharmacies.

They are not able to urinate comfortably for a long time or attend a program that involves sitting in the same position for a long time. The disorder of an enlarged prostate is known as BPH Benign Prostatic Hyperplasia (BPH). Most often this disorder is found in men which usually occurs after the age of 60 to 65 years. This is not a form of such a dangerous  as, Prostanil where to buy but, on the contrary, a normal aging health barrier found in men where to buy. It can also be due to hormonal imbalance. Although the problem may be a normal aging symptom it should. This disorder can also lead to liver or kidney problems if not given proper attention.

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One should therefore immediately begin their, Prostanil pharmacy at which time the health problem is identified. This is a natural way to cure the disorder. The fruit helps the affected male to decrease the size of the pressure on the tubes that carry urine out of the body. It helps the person to recover naturally without the participation. It is considered one of the best  to relieve enlarged prostate pharmacy. It helps the individual to reduce the inner lining of the enlarged prostate which helps to recover from excessive production of testosterone. It also helps cure other symptoms of BPH.

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Prostanil lazada, amazon - PhilippinesThey also help remove urine and also help cure BPH symptoms. They control the production of urine in the body and reduce the symptom of the disorder. Every male has a prostate in his body, which is important for his sex life lazada, Prostanil Philippines yet only a few men are aware of his prostate about what problems he may have with him. Better knowledge about this walnut-sized gland can help men make better choices about their screening.

The prostate is located under the bladder or bladder. It produces some fluid of semen and is very special for a man’s sex life. Men’s prostate also increases with increasing age amazon, but two-thirds of men over the age of 50 have no problem with it. In some cases, Prostanil manufacturer an enlarged prostate causes pressure on the bladder or bladder tube to carry urine, and this leads to urination problems. It is known as benign prostate enlargement.

Other prostate problems include inflammation ebay, which is called prostatitis, IE inflammation of the prostate. This problem can be caused by an infection. It hurts a lot while urinating. At times a single cell in the prostate starts to multiply out of control and can lead to. However, obesity and diet such as sugary foods and foods such as dairy products, and supplements such as stearic acid, vitamin E, Vitamin A and excess calcium can significantly increase the risk of prostate. In addition, Prostanil amazon randomized supplement intake during can interfere with  and cause adverse effects. 

A healthy and well-balanced diet that provides the right nutrition is important for staying away from prostate as well as reducing symptoms and improving outcomes ebay. Proper nutrition gives patients the power to handle Philippines, getting the best out of as well as improving their quality of life.  If your prostate is larger than normal size, Prostanil lazada it can spoil your sex life. In fact, the prostate gland, also known as the prostate gland, is an important semen-producing gland. At times it increases with age or due to hormonal changes manufacturer. For this reason many men also face troubles.

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MenoProtect  capsules – ingredients, opinions, forum, price, where to buy, lazada – Philippines

MenoProtect capsules - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesMenoProtect capsules for menopausal. Menopause occurs when a woman stops menstruating and is no longer able to get naturally. Menstruation usually begins to subside for a few months or even years before it stops. Sometimes they can suddenly stop. Menopause is a natural part of aging that usually occurs between the ages of 45 and 55, because a woman’s estrogen levels decrease. In , the average age of a woman to reach menopause is 51.

However, MenoProtect  about 100 out of 1 woman experience menopause before the age of 40 years. This is known as premature menopause or premature ovarian insufficiency. Most women will experience certain symptoms around menopause. The duration and severity of these symptoms vary in every woman current user reviews 2022. Menopause is a point in time 12 months after a woman’s last period. The years leading up to that point, when women may have changes in their monthly cycles, hot flashes, or other symptoms, are called the menopausal transition or perimenopause.

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MenoProtect capsules how to take it, how does it work, side effects

MenoProtect capsules how to take it, how does it work, side effectsSymptoms usually begin a few months or years before your period stops, known as perimenopause, and may persist for some time later. On average contraindications, most symptoms last about 4 years from your last menstruation. However, MenoProtect ingredients about 10 out of every 1 woman experiences it for 12 years. MenoProtect how does it work if you experience menopause suddenly rather than slowly-for example, as a result – your symptoms may get worse.

Some women experience mood swings, bad mood, MenoProtect ingredients and anxiety at the time of menopause. Self-help measures such as getting plenty of rest, exercising regularly, and doing relaxing activities such as yoga and side effects can help. CBT is a type of talking therapy that can improve bad mood and feelings of anxiety. May be able to refer you for CBT or recommend self-help options such as cognitive behavioral therapy (CBT) online. MenoProtect how to take it can help if you have been diagnosed with depression.

MenoProtect how to take it it is common for women to lose interest in sex during menopause, but HRT can often help. If HRT is not effective, you may be advised testosterone supplement what is it for. Testosterone is the male sex hormone, but it can help re-increase sex drive in menopausal women how does it work. It is not currently licensed for use in women, MenoProtect ingredients although it may be prescribed by a if they think it may help. Possible side effects of testosterone supplements include acne and unwanted hair growth. Read more about decreased libido and female sexual problems how to take it.

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If your vagina becomes dry, painful, or itchy as a result of menopause, the ingredients may recommend estrogen composition that is inserted directly into your vagina in the form of a pessary, cream, or vaginal ring. It can be safely used with HRT. You will usually need to use vaginal estrogen indefinitely capsules, MenoProtect how does it work because your symptoms are likely to return when is stopped. However, side effects are very rare. You can also use over-the-counter vaginal moisturizers or lubricants in addition to or instead of vaginal estrogen.

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MenoProtect opinions, forum, commentsMenopause is a period of life just like puberty and sexual maturity. During the period of menopause, the volume of follicles in the ovaries decreases and comments, accordingly, the production of estrogen decreases. Over time forum, estrogen production stops and the ovaries shrink. As a result, MenoProtect opinions the menstrual cycle is disrupted and the ability to reproduce is lost. The World Health Organization defines menopause as a permanent cessation of the menstrual cycle, as the ovary loses its activity opinions.

The age of menopause worldwide is 45-55 years. Studies indicate that the average age of menopause in Turkey is 46-48. What are the factors affecting menopause? What are premenopausal period disorders? What symptoms appear after menopause? How is menopause diagnosed? Sex life in menopause, MenoProtect forum how should nutrition in menopause? What to do in menopause? What is hormone replacement therapy? Who can not receive hormone therapy?

It is necessary to wear light and layers against hot flashes during menopause. Thus, MenoProtect opinions clothing can be reduced in case of hot flashes. It is beneficial to reduce spices and caffeine and avoid smoking and alcohol. Soothing oils are used against painful intercourse due to estrogen deficiency. Regular sexual intercourse is necessary to prevent atrophy. To prevent osteoporosis, MenoProtect forum it is important to pay attention to daily calcium intake and exercise regularly. If your is suitable, he can apply hormone replacement therapy.

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Hormone replacement therapy (HRT) is an estrogen replacement therapy. The patient is regularly given containing estrogen and progesterone. Hormone therapy aims to reduce the incidence of osteoporosis and cardiovascular that increase with menopause. Hormone therapy is also beneficial for symptoms such as hot flashes, sweating, palpitations and fatigue, MenoProtect comments which are common in some women current user reviews 2022. Hormone replacement therapy prevents bone loss due to menopause and increases bone mass. This reduces the risk of fracture.

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MenoProtect  how much does it cost, priceThe menopause it is defined as the permanent cessation of menstruation triggered by a decrease in egg production and a decrease in female hormones; such as estrogen and progesterone that regulate the menstrual cycle and are produced by the ovaries, it occurs when the woman reaches mature age between 40 and 59 years, a period that will depend on each person, MenoProtect price some experience menopausal symptoms such as changes in the cycle, hot flashes, headaches, may even appear emotional symptoms that include sadness, anxiety and mood changes how much does it cost.

As in menopause, this estrogenic deficiency affects different mechanisms and systems of the female organism, that is the genital apparatus, of locomotion and the cardiovascular system most affected. Women at the gynecology clinic CD of Barcelona we recommend that when a woman begins to feel menopausal symptoms or other gynecological symptoms how to face this stage and you should go to your gynecologist to determine the most appropriate.

Sudden mood swings can occur, such as anxiety or sadness. When they occur price, they are usually installed in perimenopause. The woman reports very significant changes of character in the days before menstruation and, MenoProtect how much does it cost knowing that she has no reason and wants to prevent it, it is not possible for her to achieve it. Emotionality is very hard, from a slight cry to irritation for the slightest reason.

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The ability to concentrate decreases, but memory is not lost as some women believe. In this period, insomnia, After the establishment of menopause, the woman may report a state of mind with a tendency to “depression”. If you notice such changes. Other psychological symptoms are irritability, nervousness, emotional incapacity, decreased libido, fatigue, and difficulty concentrating.

MenoProtect where to buy, pharmacy

MenoProtect where to buy, pharmacyIn the medium term, the drop in estrogen levels, producing a decreased trophism of organs that depend on these hormones, affecting in particular certain structures of the vaginal and urinary system, which produce atrophy of the skin and mucous membranes and decrease in collagen, which is the most important compound in connective tissues, MenoProtect where to buy which in turn will cause changes in the statics of these organs because it determines the degree of resistance and turgor of the tissues.

We distinguish 3 types of collagen, 1 is the most abundant, it is in the skin, bone, ligaments, tendons and arteries. The collagen content varies throughout life in pharmacies, continues to grow around the age of 25-30 years and then decreases slightly until menopause begins, MenoProtect where to buy when its deficiency becomes somewhat faster pharmacy.

Menopause is the time that marks the end of a woman’s menstrual cycle where to buy. It is a natural decline in reproductive hormones. Women undergo this change at the age of 40-50 years. It is diagnosed when a woman leaves after a year without a menstrual period. In the time leading up to menopause, you may experience vaginal dryness, loss of breast fullness, irregular periods, hot flashes, mood swings, weight gain, slow metabolism, thinning hair or dry skin. This natural, biological period cannot be avoided or corrected to achieve a previous state. However, there are and available that help you get through it pharmacy. Make sure you follow a healthy lifestyle and take MenoProtect pharmacy to the immediately as soon as you feel any symptoms of menopause.

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How is menopause. If you feel the symptoms are very painful or unbearable, you should. Hormone therapy is considered to be the most effective for dealing with menopausal hot flashes. Estrogens of the lowest dosage and shortest time frame will be administered to provide symptom relief for you. Estrogen can also be administered directly into the vagina if you want a solution for vaginal dryness. This in the form of a vaginal cream, ringed substance or tablet, releases a small amount of estrogen that is absorbed by the vaginal tissue. As neuropot and greliz may help seizures as well as reduce hot flash. Are used to provide relief from high blood pressure as well as hot flashes. After considering your condition and history, may prescribe certain or vitamin D supplements to prevent or osteoporosis.

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MenoProtect lazada, amazon - PhilippinesWhat is Menopause? Basically it means stopping your menstrual cycle. Minopause, this term is derived from the Greek words Meno and Pose, MenoProtect amazon in which Mino means month and pause means pause. Now the question is why menopause or menopause occurs, so the growing age of the ovaries producing female hormones is the cause of menopause. Decreasing female hormone secretion, infertility and some physical and psychological changes are observed lazada. So what is the age of menopause or menopause, MenoProtect manufacturer at what age does menopause occur.

These changes usually occur at the age of 45 to 50 years. With increasing age, every woman has to spend a third or more of her life with the common problems of menopause. Menopause is the normal and natural stage in woman’s life amazon. This is just a temporary stage and it is. So if we prepare well, MenoProtect lazada we can win half the battle against this problem right there ebay. Many women do not show signs of menopause, MenoProtect Philippines and many women may experience all of the following symptoms.

Every woman has to go through the menopause process manufacturer. Menopause is usually considered after 45 years. But nowadays, due to poor lifestyle, women have started getting pre-menopause. All women start going through this process of menopause around the age of 40 and it has a direct impact on their health Philippines. Here are the things that every woman needs to know about pre-menopause. Before understanding pre-menopause, women need to be fully aware of menstruation. Understand the process of menstruation in normal language like this. Eggs become in a girl’s ovary.

Between 12 and 14 years, the ovaries are fully developed and one egg is released into the uterine placenta every month. With it the two hormones estrogen and progesterone are formed. These hormones cause the lining of the uterus to thicken with blood and mucus. During this time, if the egg comes in contact with the sperm, it fertilizes and the woman. If it is not fertilized in the meantime, the thick layer of the uterus comes out of the vagina in the form of blood together with the egg, which is called menstruation or period.

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Teafy Tea drink – ingredients, opinions, forum, price, where to buy, lazada – Philippines

Teafy Tea drink - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesTeafy Tea drink to have a sexy healthy body. An expanding waistline is sometimes considered the price of getting older. For women, this can be especially true after menopause, when body fat tends to shift to the abdomen.

Yet an increase in belly fat does more than make it hard to zip up your jeans. Research shows that belly fat also carries serious health risks Teafy Tea. The good news? The threats posed by belly fat can be reduced current user reviews 2022. Women are bombarded with information about the latest diets. Working hard is good, but working smart is even better. The same principle is applied to the science of weight loss.

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Teafy Tea drink, ingredients, how to take it, how does it work , side effects

Teafy Tea drink, ingredients, how to take it, how does it work , side effectsAlso, Teafy Tea ingredients your muscle mass might diminish slightly with age, while fat increases. Loss of muscle mass also decreases the rate at which your body uses calories, which can make it more challenging to maintain a healthy weight. Many women also notice an increase in belly fat as they get older — even if they aren’t gaining weight. This is likely due to a decreasing level tea of estrogen drink, which appears to influence where fat is distributed in the body.

You can tone abdominal muscles with crunches or other targeted abdominal exercises, but just doing these exercises won’t get rid of belly fat. However, how does it work  visceral fat responds to the same diet and exercise strategies that help you shed excess pounds and lower your total body fat how to take it.

I’ve gotten a few questions lately about how I’ve lost weight over the past few months, so I thought I’d write a post! I’m writing this not as a self-celebration (since it’s still very recent, and since I’m still working on it), but (hopefully) as inspiration—because as a 52-year-old lover of food and avoider of exercise, I just really want to share what worked for me.

First, I can’t emphasize this enough ingredients: Everything I’m about to lay out worked for me, how does it work  and if any of it helps you or inspires you, that’s wonderful. But don’t take it as gospel, and definitely talk to before how to take it starting anything new. You know your body side effects and yourself better than anyone!

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An expanding waistline is sometimes considered contraindications the price of getting older. For women how to take it, this can be especially true after menopause, when body fat tends composition to shift to the abdomen what is it for. Yet an increase in belly fat does more than make it hard to zip up your jeans. Research shows that belly fat also carries serious health risks ingredients. The good news? The threats posed by belly fat can be reduced.

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Teafy Tea opinions, forum, commentsYou can tone abdominal muscles with crunches or other targeted abdominal exercises, but just doing these exercises won’t get rid of belly fat. However, visceral fat responds to the same diet and exercise strategies that help you shed excess pounds and lower your total body fat.  I’ve gotten a few questions lately about how I’ve lost weight over the past few months, so I thought I’d write a post! I’m writing this not as a self-celebration (since it’s still very recent, and since I’m still working on it), but (hopefully) as inspiration—because as a 52-year-old lover of food and avoider of exercise, Teafy Tea opinions just just really want to share what worked for me forum current user reviews 2022.

First, I can’t emphasize this enough: Everything I’m about to lay out worked for me, and if any of it helps you or inspires you forum, that’s wonderful. But don’t take it as gospel, and definitely talk to before starting anything new. You know your bod and yourself better than anyone!

Being overweight is a common problem. The that more than 70% of are overweight or obese. There’s a lot of conflicting information about the best ways to lose weight, and sometimes comments, no matter what you do, the weight can be difficult to lose. Furthermore, it may be more difficult for you to lose weight if you’re a woman opinions.

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Accept the truth about yourself and weight control. To succeed with weight loss, first we must accept that we have been eating too much — and that to lose weight and keep it off comments, we’ll have to learn how to eat less for the rest of our lives. We need to accept the science of thermodynamics that defines weight gain, loss and control in calories. In order opinions to solve our weight problem, we must find a way to eat less calorically and be happy with it. If we can, we can solve the weight problem for good.

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Teafy Tea how much does it cost, priceIf something inside you says, “My work (or whatever) is really important. There’s no way that weight control will come first,” that’s what’s keeping you from being successful. If it says, “I really don’t eat too much. There’s no way I could eat less,” that’s what’s keeping you from being successful. If it says, “I need someone else to make it easier for me, someone to make me do what’s needed.” that’s what’s keeping you from being successful. Before you have a chance of winning at permanent weight loss, Teafy Tea how much does it cost you need to confront these issues and change what you think.

What works for one person may not work for the next. When making changes, some people prefer to go all-in and change everything at the same time. But others prefer the longer, slower approach… making small changes, one at a time. Neither approach is better than the other, it’s just that people have different personalities and like to approach lifestyle changes differently price.

Women are unique and, as such, the best approach to fat loss for women is also unique. As a general rule, Teafy Tea price women have more body fat than men. Of course, this isn’t always the case, but when looking at the population as a whole, this is the trend that seems to be the most common.

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Women also tend to store more fat in their bum and thighs, whereas men usually have more belly fat. Again, not always the case, but another common trend how much does it cost. There are different theories as to why women have more body fat and store it more easily than men, but the most widely accepted has to do with evolutionary benefits and hormone levels.

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Teafy Tea where to buy, pharmacyNow that you know what healthy body fat levels look like, let’s set some realistic expectations for you before jumping into the best ways to promote fat loss for women. There are many different factors, like overall body composition, hormones and age, Teafy Tea where to buy that affect how quickly you can lose weight. But as a general rule, you should only expect to lose about 0.5-1% of your body fat each week or 2-4% each month at most.

People who are hard night-day to lose weight, they can consume. Especially, women can start taking protein if they want to keep their bodies in shape where to buy. Protein helps to retain the right body mass in the body. It builds muscle and keeps them healthy as well. Along with taking protein in limited quantities, a low-calorie diet and regular exercise to lose weight will make a difference in the body quickly.

Diet Chart for Weight Loss for Female obesity is not good for anyone but it is also important to take a bite of taste. In today’s hectic life, people do not take care of their food and drink pharmacy and the result is obesity, which causes people, especially girls, to suffer a lot. Don’t be able to wear your favorite dress and do the things you like after having to deal with a lot of troubles, then they come to mind the gym, yoga and dieting. I will tell you about diet chart for weight loss today where to buy. People do a lot for weight loss but in most cases the effect can’t be achieved and people get frustrated.

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Teafy Tea lazada, amazon - PhilippinesBody mass index (BMI) is known by measuring weight in kilograms and dividing it by meters square of length. To find out your own BMI you can use NHS BMI healthy weight calculator. Weight loss programs can be quite challenging, Teafy Tea Philippines but it helps those who consistently follow the rules of those programs to reduce obesity.

Researching obese people lazada who completed a commercial weight loss program that lasted 12 months, found that they lost about 5-10% of their body weight. Although this does not seem manufacturer to be a great achievement. But even a slight decrease in weight is quite beneficial for good health. Most women are worried about their weight gain, Teafy Tea amazon as the weight increases slowly due to improper diet and lifestyle.

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If you’re doing all the right things and your weight remains the same, make an appointment with a registered, who will help you create a customized plan ebay to reach your goals amazon.  By nature, women tend to have a lower metabolic rate than men. This means your body uses fewer calories (units of energy) to fuel normal body functions like breathing, thinking, and circulating your blood. The leftover calories are stored as fat.

Plus, female body composition usually exceeds males’. In other words, men tend to pack on pounds made of more muscle than fat, lowering their body mass index (BMI). Muscle ebay, conveniently for men, burns more calories than fat — even at rest. For ages, people have asked, “Do women have a harder time losing weight?” Physiologically, women have an easier time hanging on to excess weight.

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Fit&Sleep capsules – ingredients, opinions, forum, price, where to buy, lazada – Philippines

Fit&Sleep capsules for losing weight. There are some people who are constantly gaining weight. Then do not know what measures to follow with your diet to control weight. Due to which many people take a little more stress. In this case, if you are also engaged in trying to lose weight, Follow Simple Tips. Fatigue and following a good diet will definitely make you lose weight current user reviews 2022.

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Several research has confirmed that obesity also increases the risk of Type 2 diabetes and certain types of cancer. This is why people do everything possible to reduce obesity. If you are worried about obesity, Fit&Sleep ingredients here are the best tips that you can follow every day to lose weight. People often make great efforts to lose weight. Being overweight can turn into a serious concern. It also affects the health of the individual. However, there are also some effective ways to lose weight, which we can easily lose weight if we include in our routine contraindications.

It requires patience, commitment and dedication. Let’s know what are the effective ways that will help you lose weight. Excessive fat accumulated on the abdomen and waist is of concern. It not only looks bad in appearance, but can also cause many. Through this article from stylecrase we will learn how to lose belly fat. For this, we will talk about effective exercise, yoga and diet that can help reduce belly fat.

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Women resort to dieting to reduce belly fat. Due to dieting, the body begins to lack vitamins and nutrients. Women need a healthy diet plan (Weight loss tips for women) Fit&Sleep opinions for weight loss. With a weight loss diet plan, a better lifestyle is also important. If you are not losing belly fat, follow these weight loss tips.

These daily diet and lifestyle tips are more effective than dieting to reduce abdominal obesity. Let’s know what women should do to lose belly fat and lose weight. When dieting to lose weight, Fit&Sleep forum it is forbidden to eat the only thing that is preferred. But you don’t have to do it at all, you have to eat the thing you like but pay attention to the quantity comments. The most important diet tips for weight loss is that you always have to eat from time to time current user reviews 2022.

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Most women face a lot of problems in their weight loss forum. Many women try a variety for weight loss. Go to dieting. Fit&Sleep forum some even sweat for hours in the gym. Take time and make a variety of efforts, so that the weight is reduced. Now you need not bother much. Try to follow a special diet chart regularly for a few days. Fit&Sleep comments this will reduce your weight very soon. Learn opinions, about this diet chart. www.Fit&

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Weight Loss Tips For Women weight gain and obesity in women is a very serious problem today. Weight loss methods are the most searched question on the internet today. Weight gain is more common in women than men because women spend most of their time. In addition, women have different muscle levels than men. Weight gain and obesity can trap your body in a variety. Fit&Sleep how much does it cost there are many reasons for weight gain in women such as not doing physical activities and exercise price. Let’s get to know Weight Loss Tips for women in detail.

Consuming less refined carbs is the easy way to lose weight in women. Refined carbs undergo more processing so the fibre and micronutrient content in them decreases. Refined carbs increase blood sugar levels, increase appetite and also increase body weight and abdominal fat. It is therefore best to limit consumption of refined carbs such as white bread, pasta and packaged foods. Instead you eat whole grain products like oats, brown rice, quinoa, and barley.

The easiest and most effective way to reduce weight are to do physical activity. Women add weight training exercises to their daily routine to lose weight. Exercising helps burn excess calories from your body. Weight training exercises also help protect bone mineral density from osteoporosis. In addition to weight training exercises, you can make women lose weight by biking, swimming, and jogging.

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Fit&Sleep price women to lose weight set a regular sleep schedule. Studies show that getting enough sleep can also be important for weight loss, like diet and exercise. According to several studies, lack of sleep is responsible for increasing body weight and high levels of hormone to stimulate appetite how much does it cost, so getting enough sleep is important. Also a study in women showed that sleeping at least seven hours each night and improving overall sleep quality helps with weight loss. www.Fit&

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Women to reduce their weight create a diary in which they write down all the information about their food. Fit&Sleep where to buy, pharmacy using a food journal to track what you eat is the easy way to reduce your weight. It also makes it easier to count calories, which can be an effective strategy for weight management. This will help you keep track of your daily calorie intake and keep your weight low for a long time.

Nowadays it has been seen that some people are very crazy behind fitness. Women are not far behind. Women are more concerned about their health and figure than men. But it has been observed that women are not able to remove excess fat due to physical appearance. While some small things can be taken care of, Fit&Sleep where to buy, pharmacy fat can be removed. Let’s go to the weight loss tips for women which are as follows.

‘Getting back in shape’ – these are the words that are said to be simpler than done. Fit&Sleep pharmacy some people behave with a new vigor every day and attack them with the aim of losing excess fat where to buy. But in most cases even after spending hours in the gym and having a regular diet can not decrease the weight ratio pharmacy.

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Chances are they’re ignoring one fundamental principle in any weight loss process – doing things the right way. Taking out gym hours and being hungry can make you not lean pharmacy. Other health circumstances could lead completely. For proper weight loss it is imperative to have a proper schedule in both exercise and diet. Let’s go through some common mistakes that hinder weight loss.

A good dietitian says- “Be patient in any weight loss.”This is very true because weight loss is a step-by-step process and avoiding these common mistakes can make the effect more profound and eternal in pharmacies. If you want to discuss about a specific problem, you can a dietician-nutritionist. www.Fit&

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Losing weight according to a plan is safe. Losing weight quickly during this time is not recommended and you should therefore lose weight slowly. The best way to lose weight is to keep your lifestyle healthy, eat less fat, and exercise regularly daily. Fit&Sleep lazada a also helps the mother lose weight because during this time, the stored fat in the mother’s body makes milk and gets energy.

When to start losing weight? It is very challenging for a mother to handle and her other preferences after delivery needs more care at this time. You should not worry much about losing weight during this time Philippines. Because if it has taken about 9 months to gain weight you should also spend the same amount of time for weight loss ebay.

There is a rule ebay when it comes to losing weight, of 80-20. This means that only 20 percent of your workouts should be involved in losing weight and the rest 80 percent of the weight should be reduced with the help of a diet. Awareness of diet can make your work easier while continuing with fitness efforts. Fit&Sleep amazon the results may surprise you lazada. So learn about foods that can be a step in the weight loss mission.

The first tip on our list of weight-loss amazon tips for women is super simple, but very few women actually follow it. Thirst is easily mistaken for hunger, especially in the morning. Fit&Sleep manufacturer if you start your day trying to quench your thirst with food, you’re likely to keep that process up throughout the rest of the day.

If you’re planning on eating more healthy foods manufacturer, the best way to do so is to keep them out and readily available. That way, Fit&Sleep Philippines even if you find yourself in the kitchen looking for a snack to curb your boredom, you’ll find the fruit bowl or your favorite healthy snacks jumping out at you instead of a bag of chips or worse. www.Fit&

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Specialift cream – ingredients, opinions, forum, price, where to buy, lazada – Philippines

Specialift cream - ingredients, opinions, forum, price, where to buy, lazada - PhilippinesSpecialift cream help to reducing wrinkles. Wrinkles were once considered a sign of old age, but today this problem has become common among young people. The reason is spoiled routine and irregular eating habits. At the same time, insomnia, anxiety, and stress can also be important causes. If you are facing this problem in time, then no need to worry. All you need is to rotate your home once. Indeed, of wrinkles is hidden only in your kitchen. In this article of stylecrase we will tell you about the to remove facial wrinkles as well as the causes, symptoms and some ways to avoid it current user reviews 2022.

Aging is a part of life. Every year passes, Specialift cream for the better if your having adding years to our lives. With age, we forget to take care of our skin. Can you see fine lines and streaks all around your eyes?  Yes? This means you are getting wrinkles. The skin around your eyes is so thin that, it is easily affected, causing wrinkles. Be careful! This is the first stage of aging.

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Specialift cream, how to apply, how does it work, side effectsSpecialift ingredients eye wrinkles damage the beauty of your face and the smoothness of your skin. How do you get rid of this problem? Thinking of going to the salon for some beauty ? You may prefer to use laser treatments, dermal fillers, Botox, microdermabrasion – to achieve good results, but they are not long-lasting. These require your time and are very expensive. You have a tight budget? If you have a low budget, you can choose eye creams of any brand available on the market. Massaging around your eyes with cream will help you reduce your wrinkles contraindications. Still looking for other solutions?

No need to worry, because your kitchen items are great for ridding you of unwanted wrinkles. Specialift ingredients are you also bothered by wrinkles on the forehead at a young age. These wrinkles on the forehead affect your beauty. Appearing on the skin signs of old age at an early age can be a serious problem. Many times stress, lack of proper facial care, fatigue, nutritional deficiencies in food, etc. are the main causes side effects of premature wrinkles ingredients.

Specialift ingredients to reduce wrinkles, women and young women often use products cream  on the market, which do harm rather than benefit. Try natural  to get rid how does it work of these untimely developing wrinkles how to apply. Specialift how does it work apply cream in the palms and apply well on the forehead where there are wrinkles. Leave the oil on the forehead overnight. Specialift how to apply a couple of times during the night or during the day. Cream contains which works as a great skin-conditioning agent.

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This cream is also rich in antioxidant properties, which helps keep forehead skin healthy as well as remove lines on untimely forehead. Let the dry and wash with water afterwards. Specialift how to apply you can make a face composition pack by grinding citrus fruits like lemon and orange peels, adding rose water to them. Also start consuming citrus fruits. Apply lemon juice once a day. Specialift how does it work are rich in vitamins-C and E, so it is very beneficial for skin health. The flavanoids present in citrus fruits strengthen the cells. Maintains collagen and elastin in the skin, keeping the skin young what is it for.

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Specialift opinions, forum, commentsWho would want a withered wrinkled face to appear when he woke up in the morning and looked at his face in the mirror. Specialift opinions there was a time when wrinkles were considered a sign of aging. But, nowadays, it’s no surprise if they begin to appear even at your 20-30 age. In today’s hectic life, stress, lack of sleep and improper diet often damage the skin, and all of this causes you to wrinkle without wanting it.

The moment you realize that the slightest wrinkles on your face have begun to knock. Specialift forum you also start looking for solutions from that moment. You don’t want the wrinkles to grow so much that they get noticed by everyone and you don’t want expensive. Well, there are many remedies that are completely natural and best of all, they can be using ingredients. Specialift opinions so it can be used from young to elderly, it also has no side-effects. So, in this article, we will talk in detail about what wrinkles are and how they occur and how to get rid of them current user reviews 2022.

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Specialift forum facial skin is very soft and thin compared to the rest of the body opinions. Therefore, wrinkles on the face begin to appear very easily. Laughing lines around the eyes, on the forehead and on the face, or what we also call loff lines, all of these symptoms easily identify wrinkles forum. Wrinkles are also seen on the neck where the skin begins to fall out with age. Wrinkles on the chest comments, on the hands and even on the legs gradually begin to show their effect. Specialift comments so now let’s not wait too long and tell you how to prepare this natural.

Specialift how much does it cost, price

Specialift how much does it cost, priceThe first wrinkles tend to appear on a person’s face in areas where the skin naturally folds during facial expressions. They develop due to the skin becoming thinner and less elastic over time. Wrinkles also tend to appear on parts of the body that receive most sun exposure, such as the face and neck, back of the hands, and arms.

Wrinkles are a natural part of growing older, and they affect everyone. However, many people dislike the appearance of wrinkles, and, as a result, the anti-aging market in the United States is worth over 50 billion dollars per year. Specialift how much does it cost this article looks at why people get wrinkles, what causes them, and what increases their appearance. Specialift price it also looks at some methods that people use to reduce wrinkles, some of which are more effective than others.

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Wrinkles are a natural part of the aging process. As people get older, their skin becomes thinner, drier, and less elastic, which means it is less able to protect itself from damage. This leads to wrinkles, creases, and lines on the skin. Facial expressions, such as smiling, frowning, or squinting, lead to the development of fine lines and wrinkles at a young age. These lines deepen as the person gets older how much does it cost. When a person is young, their skin springs back. As they get older price, the skin loses its flexibility, and it becomes more difficult for the skin to spring back, resulting in permanent grooves.

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Specialift where to buy, pharmacyWrinkles affect people of different skin tones differently due to structural and functional differences in the skin. ResearchTrusted Source indicates that the compact dermis is thicker in the skin of Black and Asian people, which likely protects against facial wrinkles. Exposure to ultraviolet (UV) light from sunbathing, tanning booths, and outdoor sports increases the development of wrinkles.

UV light breaks down the collagen and elastin fibers in the skin. These fibers form the connective tissue that supports the skin. As this layer breaks down, the skin becomes weaker and less flexible pharmacy . The skin starts to droop, and wrinkles appear. Darker skin contains more melanin and protects from many harmful effects of UV radiation. People who work in sunlight have a higher chance of early wrinkles. Wearing clothes that cover the skin, Specialift pharmacy  such as hats or long sleeves, may delay the development of wrinkles.

Regular smoking accelerates the aging process of skin because it reduces the blood supply to the skin. Alcohol dehydrates the skin, and dry skin is more likely to develop wrinkles. Specialift where to buy, pharmacy wrinkles are a normal part of the aging process. Fine lines appear first, and then the creases deepen when the skin begins to lose its elasticity. People can use various treatments to reduce wrinkles. Lifestyle changes, such as moisturizing, wearing sun protection, eating a healthful diet, avoiding smoking, and drinking less alcohol, may help prevent or delay the appearance in pharmacies  of wrinkles where to buy.

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Forehead wrinkles can make your age look much older pharmacy , but the good thing is, there are many things you can do to reduce the appearance of these wrinkles and even completely relieve them. In many cases, lifestyle changes can also help you, but if you want to fix them quickly, Specialift where to buy, pharmacy then you should think about taking. Wrinkles are part of the natural aging process, but slowing down this process is possible even if you take good care of your skin.

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Specialift lazada, amazon - PhilippinesSpecialift lazada you can achieve this by leading a healthy lifestyle that keeps your skin looking as young as possible and causing exfoliation to cleanse the skin and eliminate dead cells. If all this does not work out for you, there are also  procedures to reduce wrinkles. Aging is a natural process and its most obvious external projection is the appearance of wrinkles and straight lines. Our skin tends to age from the late 20s, but its effects become more pronounced as we age.

Collagen and elastin are two major proteins that are the basis or cell structure that makes the skin elastic, supple and young Philippines.  Over time, these proteins begin to reduce wrinkles, lines and the appearance of dark hair on the face, forehead, neck and back of the hands. Specialift amazon while there will be many over the counter creams and creams on the market for beautiful skin that help with skin aging, we all know how good ebay. Which does not give any side effects on our skin. One of the most effective natural that helps tighten wrinkles and lines and tighter skin. It is a rich source of vitamins, minerals and natural fatty acids that nourish the skin because it is easily absorbed by the skin.

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Specialift Philippines every person wants them not to look lazada. He wants to see his face feeding. But if your face becomes wrinkled at a young age, you may not even like to wake up in the morning and look at your face in the mirror and you may never want to see wrinkles on your face ahead of time amazon. If you have wrinkles on your face at the age of 20-30 years, you will be upset. In today’s changing lifestyle, you can’t get enough sleep and can’t even eat properly because of the rush. Even if you don’t want this routine, you are harmed.

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- Acutis team
Animal microbiomes hold the key to new antifungals

Because of an increasing number of immunocompromised people with underlying diseases and treatments for other diseases like transplantation and cancer, fungal infections (mycosis), and diseases caused by fungus (yeast or mold) are increasing. Fungal infections are most common on our skin or nails and are easy to treat. However, some fungi can also cause deep infections in the mouth, and throat, or life-threatening systemic infections in the lungs, urinary tract, and many other body parts, mostly among immunocompromised individuals. Moreover, the rise of multidrug-resistant fungal infections, mostly in hospital settings infecting patients via breathing machines or catheters, is highly troubling.

Because of the increasing numbers of patients with such infections and the development of anti-infective resistance to these agents, without the current availability of many antifungal agents, the world desperately needs new antifungals to combat these infections. Although little attention has been given from governments and industry alike, some scientists are taking unique approaches to the quest for new antifungals. Many novel approaches like antifungals from soil to animals, antifungals from under the sea, insect-derived antifungals, antifungals from animal gut microbiota, etc., are currently in the limelight with huge hopes for novel antifungal agents in the near future.

Read the full article here

- Acutis team
What happens when you catch more than one virus?

We are witnessing a unique situation of ‘Tridemic’ with increased hospitalizations for seasonal flu and Respiratory Syncytial Virus (RSV) infections along with ongoing COVID-19. This has provided scientists with an opportunity for an in-depth study of a long-known but not well-studied phenomenon called ‘Viral Interference,’ where one infection can interfere with another. Scientists are trying to get answers on what happens if more than one virus infects an individual simultaneously.

As of now, most of the knowledge about infections, their pathogenesis, and epidemiology are mostly based on one pathogen – one disease model, which is, in fact, way far from reality. The results are accumulating to suggest that host coinfections could lead to positive and negative interactions between viruses. There is evidence of positive interactions between parainfluenza viruses, which cause respiratory infections in infants and young children, and between metapneumovirus and RSV—which are quite common in young children. In contrast, negative interactions have been reported between influenza B and adenoviruses and between rhinoviruses and the influenza A virus. Infections with rhinoviruses, the most common culprit behind the common cold, have also been found to block flu infections.

Read the full article here

- Acutis team
What are the benefits of Polymerase Chain Reaction (PCR) testing?

First, let’s start with what Polymerase Chain Reaction (PCR) testing is. A PCR test is a laboratory technique used to amplify small amounts of DNA to make it easier to detect and analyze. The test works by using a specific enzyme called polymerase to make many copies of a specific region of the DNA.

The PCR process includes three basic steps. Denaturation: The DNA is heated to a high temperature, causing the double helix to separate into two single strands. Annealing: A specific primer is added to the sample. The primer is a short piece of DNA that is complementary to the target region of the DNA. The primer binds to the target region and starts the replication process. Extension: The enzyme polymerase is added to the sample. Polymerase reads the template DNA and synthesizes a new strand of DNA that is complementary.

This process is repeated multiple times, and with each cycle, the number of copies of the target DNA is doubled. This leads to exponential amplification of the target DNA. PCR tests are widely used to diagnose various diseases, such as viral infections, cancer, and genetic disorders, as well as in forensic science, genetic engineering, and biotechnology. They are also used to detect the presence of specific microorganisms, such as bacteria or viruses, in a sample.

Benefits of PCR Testing Urinary Tract Infections (UTIs) for Doctors.

There are several benefits for healthcare providers and doctors who use PCR testing in their practice.

Improved patient outcomes: By using PCR testing, doctors can quickly and accurately diagnose UTIs, which can lead to improved patient outcomes. This includes reducing the risk of complications, preventing the spread of infection, and ensuring that patients receive the appropriate treatment. Reduced antibiotic resistance: By using PCR testing to accurately diagnose UTIs and target treatment to specific bacteria, doctors can reduce the overuse of antibiotics and help slow the development of antibiotic resistance. Reduced healthcare costs: By quickly and accurately diagnosing UTIs and providing appropriate treatment, doctors can reduce the need for additional testing and follow-up visits, which can help to reduce healthcare costs. Better patient satisfaction: By providing accurate and prompt diagnosis and treatment, doctors can improve patient satisfaction with their care. Improved infection control: By using PCR testing to detect asymptomatic UTIs, doctors can improve infection control by identifying and treating patients who may be spreading infection without realizing it. Better management of patients with recurrent infections: PCR testing can help identify the cause of recurrent infections, which can help physicians to provide better management for those patients, reducing the costs and burden on the healthcare system. Better management of patients with comorbidities: PCR testing can help physicians to better manage patients with comorbidities, such as those with chronic kidney disease, diabetes, or immunocompromised patients. Benefits of PCR testing for patients

In addition to the benefits of PCR testing for healthcare providers and doctors who use it in their practice, Polymerase Chain Reaction (PCR) testing for urinary tract infections (UTIs) in patients has several benefits.

High sensitivity and specificity: PCR tests are highly sensitive and specific, which means they can accurately detect the presence of bacteria that cause UTIs, even in small amounts. This can help to ensure that patients receive the correct diagnosis and treatment. Faster results: PCR tests can provide results in a matter of hours, which allows healthcare providers to quickly diagnose and treat patients, reducing the risk of complications. Can detect multiple types of bacteria: PCR tests can detect multiple types of bacteria that cause UTIs, including antibiotic-resistant strains. This can help to ensure that patients receive the appropriate treatment. Can detect mixed infections: PCR tests can detect if a patient has a mixed infection, which means more than one type of bacteria is causing the UTI. This is important as it can help guide the treatment choices for the patient. Can detect asymptomatic patients: PCR tests can detect UTIs in patients who do not have symptoms, which can be important for preventing the spread of infection and ensuring that patients receive prompt treatment.

Learn more about testing with Acutis

- Acutis team
Screen all patients for cannabis use before surgery: guideline

Substance Use Disorder (SUD is a growing public health problem with an estimated 165 million people among 12 and older in the US using some sort of substances (Cannabis, tobacco, alcohol, kratom, an illicit drug, etc.).

About 18% of people in the US (~48.2 million) used cannabis products at least once in 2019. Frequent use leads to Cannabis Use Disorders (CUD) if continued its use despite causing health and social problems in their lives. The CDC data estimated that approximately 3 in 10 people who use Cannabis have CUD. Along with several challenges they are already facing, a recent study showed that long-term cannabis use was associated with a 20% increase in the incidence of postoperative complaints including nausea and vomiting. CUD was also associated with increased reports of pain leading to the need for more opioid based medications.

Because of these findings, as per the recommendations from the American Society of Regional Anesthesia and Pain Medicine (ASRA), all patients who undergo surgical procedures that require regional or general anesthesia should be asked if, how often, and in what forms they use cannabis.

Read the full article here

- Acutis team
What’s behind the recent surge in strep A and scarlet fever?

An off-season outbreak of the Strept A infection is troubling the US Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). These infections are caused by the bacteria Streptococcus pyogenes, a harmless normal flora of the skin or respiratory lining. Since Streptococcus comes in various forms and can trigger an array of symptoms from a mild sore throat to pneumonia, life-threatening blood and organ infections like necrotising fasciitis ("flesh-eating disease"), streptococcal toxic shock syndrome, or autoimmune diseases like rheumatic fever and post-streptococcal glomerulonephritis; WHO ranks this organism among the deadliest pathogens on earth.

There is a report of an increase in invasive group A streptococcus (iGAS) infections at least in five European countries that killed 13 children in England and made more ill. While CDC is closely investigating a possible increase of iGAS diseases in the US, scientists are alerted and trying to answer the questions like what is behind the recent surge in Strep A infections, how problematic is this, why are these infections occurring now, how worried should we be, etc. More than ever, there is a greater need for a proper and timely diagnosis of such infections before it takes the worst path using reliable diagnostic tests like Acutis Reveal™ RIT.

Read the full article here

- Acutis team
COVID ‘variant soup’ is making winter surges hard to predict

Although the overall cases of COVID-19 seem to be falling, the mixes of variants, including the unprecedented diversity seen with immunity-dodging offshoots of the Omicron variant of SARS-CoV-2, it is very hard to predict the upcoming waves of infection. Because of such an intense proliferation by descendants of Omicron with the same mutations coming up over and over, scientists worry about the possibility of some ‘double waves’ in some places, as first one variant and then another overtaking a population subsequently.

Amidst such uncertainty, the available data are leading to some patterns. Scientists are. pinpointing a handful of immunity-evading mutations that power a variant’s spread globally. In Europe, North America, and Africa, the prevalence of Omicron offshoots in the BQ.1 family seem to be rising quickly. In Asian countries, including Singapore, Bangladesh, and India, a lineage called XBB dominates the fresh waves of infections. To simplify it, both strains seem to be circulating in several regions. It is not yet known the extent to which infection with one lineage elicits cross-immunity against the other. Scientists worry that the cold Northern Hemisphere winter weather could give SARS-CoV-2 circulation a boost, leading to unforeseen waves.

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- Acutis team
COVID jabs for kids: they’re safe and they work — so why is uptake so patchy?

Completing the vaccination has remained key in preventing severe COVID-19 in every age group. Amidst these ongoing waves of ‘Tri-demic’ where hospitals across the country are filing with children infected with three viruses [Influenza, Respiratory Syncytial Virus (RSV), and SARS-CoV-2], the importance of complete vaccination in younger children is more important than ever. Despite being extremely safe for kids and good at preventing severe disease, the vaccination among kids aged 5 – 11 varies widely across the globe with as low as only 3% vaccination in some European countries. The most widely used vaccines in kids are the ones based on mRNA, offered to close to 90% of countries and regions across the globe. Scientists are perplexed by the fact that there is a low vaccination rate in some countries despite these mRNA vaccines being safe for everybody, including children.

Additionally, on January 11th, the FDA encouraged everyone to maintain their protection by getting a bivalent COVID-19 vaccine booster dose.

Since this newly approved bivalent COVID-19 vaccine is proven to have an “unparalleled” safety record, highly effective to protect against the dominant Omicron variant, also known in preventing other emerging strains and deemed effective in preventing severe COVID-19; Scientists urge everyone including young kids to be UpToDate with their vaccination against COVID-19.

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- Acutis team
Trending clinical topic: Antibiotics for UTI

Urinary Tract Infections (UTIs) involve the infection of any part of the urinary system including kidneys, ureters, bladder, and urethra. American Urological Association estimates that 150 million UTIs occur worldwide annually and cost up to $6 billion in healthcare costs. Unfortunately, UTIs can be difficult to diagnose and most often patients are treated based on symptoms alone which has an error rate of approximately 33%. Recent data reiterates that the antibiotic regimen for UTIs should be tailored to ensure an appropriate 'bug-drug match'.

A recent study involving over 670,000 young women diagnosed with UTIs is troublesome as almost half of the participants received an antibiotic that was inappropriate, and more than 75% were prescribed antibiotics for a longer duration than was necessary. Since many of these UTI pathogens are prime contributors to antimicrobial resistance (AMR), this data has prompted agencies to update prescribing guidelines to avoid the risk of further AMR.

While such guidelines would ultimately ameliorate the problem, as of now, diagnosing UTIs right away using prominent diagnostic tests like Acutis Reveal™ UTI, a multiplex PCR-based test with 96-100% sensitivity and 100% specificity, is the way forward to ensure an appropriate 'bug-drug match'.

Read the full article here

- Acutis team
Novel agents in development for multidrug-resistant gram-negative infections

Antimicrobial Resistance (AMR), specifically the multidrug resistance (MDR), is the biggest public health threat of the era with projections for ~10 million deaths per year by 2050. Severe infections like nosocomial pneumonia, sepsis, and complicated urinary tract infections (cUTI) remain associated with significant morbidity and mortality. The AMR among many pathogens encountered in all types of infections has exploded over the last 2 decades. Although the organisms like Staphylococcus aureus mostly posed the threat of AMR traditionally, AMR in Gram-negative bacteria (GNB) like Enterobacterales spp. (e.g., Klebsiella pneumoniae, Escherichia coli), Pseudomonas aeruginosa, and Acinetobacter baumannii etc. has now supplanted Gram-positive pathogens.

Given the evolving burden of MDR infections, accelerated efforts are in place to emphasize the development of novel therapies. Recent clinical trials provide encouraging data about four novel agents (Tebipenem, Durlobactam-Sulbactam, Cefepime-Taniborbactam, and Xeruborbactam) in various phases of development. These agents have demonstrated a unique range of in-vitro activity against select MDR pathogens. While these are promising developments for future, as of now, diagnosing infections promptly using kits like Acutis Reveal™ covering these MDR pathogens to minimize the unintended/unnecessary use of antibiotics and treat appropriately at first, is the only measure to curb down the burden of AMR.

Read the full article here

- Acutis team
RSV is surging: What we know about this common and surprisingly dangerous virus

Amidst flu season and ongoing COVID-19 waves, it is concerning to see children’s hospitals around the country filled with patients infected with Respiratory Syncytial Virus (RSV) – a phenomenon commonly discussed as ‘Tridemic’ or ‘Tripledemic’. Despite being so common for a long time, RSV was not getting much attention earlier. Because of the complexity of this ‘Tridemic’, many parents are now anxious to learn more about this.

Based on the gradually gained knowledge over 15+ years about this common and surprisingly dangerous virus, scientists have tried to answer many common questions including what is RSV, what are its symptoms, how is RSV transmitted, how severe is an RSV infection, why are cases surging now, is there a vaccine for RSV, how is RSV treated, what should someone do if they think they or a family member has RSV, when should someone with RSV go to the hospital, and what can one do to protect vulnerable people from RSV.

More than ever, it is very important to identify pathogens quickly and properly by using tests like Acutis Reveal™ respiratory infection test (RIT) that can detect up to 22 major respiratory pathogens including RSV A and B within 24 hours.

Read the full article here

- Acutis team
Preparing the world for the next pandemic

Although COVID-19 took countless lives and the world’s response was not perfect, it has taught us several lessons potentially useful to respond to future pandemics. Unfortunately, predictions are grimmer for many similar or even worse pandemics necessitating countries to ensure that they are better prepared to deal with pandemics than they were for COVID-19.

Throughout the pandemic, we witnessed high points such as the speed of vaccines and diagnostics development as well as low points such as the unequal distribution of those resources globally and confused messaging revealing weaknesses in how public-health authorities communicate.

Out of the many lessons learned, some important ones include the need for global zoonoses monitoring, obtaining and sharing the genetic sequences of viruses globally as they emerge, strengthening the manufacturing of diagnostics and vaccines, developing vaccines for rapid production in advance, and stopping the spread right away at its origin. Newer advancements like machine learning and climate modeling could be very useful for achieving such goals, especially in predicting infectious-disease outbreaks.

In summary, preparing for future pandemics involves strengthening the entire chain of the outbreak response, from identifying a pathogen with proper diagnostics to timely mass vaccination.

Read the full article here

- Acutis team
What we learn about Antibiotic Polymyxin
Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane

The uncontrolled rise and spread of Antimicrobial Resistance (AMR) have transformed from individual observations in the 1940–1960s into a worldwide multi-drug resistance (MDR) crisis with a grim projection to kill ~10 million people per year by 2050. Amidst several ongoing innovations to look for solutions, Scientists from Switzerland utilizing new high-resolution microscopic images, showed that Polymyxins, one of the mysterious last-resort antibiotics, crystallize the cell membranes of bacteria. Scientists utilized a powerful tool called atomic force microscopy (AFM) along with structural biology and biochemistry assays to study how polymyxin antibiotics interact with lipopolysaccharide (LPS) in bacterial membranes.

They discovered that polymyxins arrange LPS into hexagonal assemblies to form crystalline structures. After almost a hundred years of its use, scientists provided evidence to suggest that the formation of rigid LPS–polymyxin crystals and subsequent membrane disruption is the mechanism of polymyxin action. This discovery could provide a benchmark for optimization and de novo design of LPS-targeting antimicrobials, with hopes to tackle the AMR problem more efficiently. While these are promising developments for the future, as of now, diagnosing infections promptly using kits like Acutis Reveal™, and treating them appropriately at first is the only measure to curb the burden of AMR.

Read the full article here

- Acutis team
Omicron XBB.1.5 accounts for 43% of US COVID cases

Although serious illness and hospitalization from severe COVID are remarkedly low, the recent rise of Omicron Subvariant XBB.1.5 is highly concerning.

First detected last October in the US, XBB.1.5 has been circulating in at least 38 countries, including Canada, Australia, Kuwait, Germany, and France, and now accounts for 43% of the COVID-19 cases in the US for the week ending Jan 14, a sharp rise from only 27.6% and 18.3% for the week ending Jan 7 and Dec 31 respectively.

XBB.1.5, unofficially named Kraken, is a combination of two strains of the subvariant BA.2. On Jan 4, WHO called this the “most transmissible subvariant detected yet”. WHO has no definitive evidence that Kraken will lead to more severe disease than its predecessors. However, since the mutations within this subvariant of Omicron allow this virus to adhere to the cell and replicate more quickly, scientists warn everyone to be highly vigilant till definitive evidence arises in either direction.

Since the bivalent vaccine, which includes a combination of the original virus and the Omicron variant, continues to provide “good protection” including against XBB strains in terms of preventing severe acute disease, scientists urge everyone to get boosted ASAP.

Read the full article here

- Acutis team
Cocaine use creates feedback loop with gut bacteria: mouse study

While progress is made day by day, Antimicrobial Resistance (AMR) remains the biggest public health threat of the era with projections for ~10 million deaths per year by 2050. New studies reveal that controlled substances like Cocaine, have a negative impact on gut microbiota, increasing epinephrine levels, which not only influences animals’ response to these substances but also promotes the virulence of certain bacterial species, potentially affecting the AMR equation.

A mice study showed increased norepinephrine levels following Cocaine use that facilitated Proteobacteria colonization in the gut. Such colonization depleted glycine in the gut, blood, and CSF that altered Cocaine-induced neuroplasticity and drug responses. There are pieces of evidence supporting the fact that gut microbiome composition is linked to human behavior and gut bacteriophages are linked to cognition. Since the mice infected with the bacterium Citrobacter rodentium, the murine counterpart of a pathogenic E. coli in humans, are known to sense neurotransmitters from its host and increase its virulence in response to them, although just shown in mice for now, this could be a groundbreaking discovery to pave paths in solving the mystery of AMR, as well as could potentially be exploited to modulate reward-related brain circuits that contribute to SUDs.

Read the full article here

- Acutis team
FDA to Review a Preventative RSV Treatment

The news that the FDA accepted licensing application from Astrazeneca/Sanofi for its expedited review for a single-dose long-acting antibody (Nirsevimab) is highly encouraging. This is indicated to prevent Respiratory Syncytial Virus (RSV) infections in newborns and infants entering or during their first RSV season, as well as children aged up to 24 months who are vulnerable to severe RSV disease through to their second RSV season.

Nirsevimab demonstrated up to 74.5% reduction in lower-respiratory tract infections, such as bronchiolitis or pneumonia, caused by RSV, and would become the first and only single-dose, passive immunization for a broad newborn and infant population in the US. This brings us one step closer to providing an effective protective option against this incredibly contagious disease responsible for the hospitalization of babies less than 1 year of age. This has already been approved in Europe and if everything goes well, it is expected to be approved in the US by the third quarter – just in time for the 2023/24 RSV season. Till then, scientists reiterate the importance of quickly and properly identifying pathogens by using tests like Acutis Reveal™ respiratory infection test (RIT) that can detect up to 22 major respiratory pathogens including RSV A and B within 24 hours.

Read the full article here

- Acutis team
Slow vaccine delivery may maximize immune response

Although the rapid development of COVID-19 vaccines saved countless lives, lessons taught to us by the COVID-19 pandemic with varied and not optimal protection by these vaccines have urged the scientific community to look for better strategies to maximize the vaccine's efficacy. Scientists have learned that the best vaccines are the ones that mimic what an actual infection looks like without making you sick. Scientists have developed a new vaccine strategy involving formulation changes, an initial escalating dose, and a longer wait for booster immunization resulting in more-effective antibody production against HIV.

Evidence suggests that the changes in formulation, escalating initial dose, a longer wait for booster immunization, etc. trigger an effective immune response by properly training B-cells to generate antibodies that bind and neutralize the pathogen in question. It seems to provide an optimal condition for B-Cells to start evolving through a process of random mutation and selection for cells that produce antibodies with better affinity for that antigen. Although this strategy was tried in HIV, scientists believe this novel proof of concept might be useful in designing vaccines against difficult targets, including the development of better vaccines against COVID-19 and a universal flu vaccine that provides protection against many different strains.

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- Acutis team
Hemithioindigo-based visible light-activated molecular machines kill bacteria by oxidative damage

Antimicrobial Resistance (AMR) is an unintended natural phenomenon that occurs when microorganisms are exposed to drugs. It is a growing health threat, and without prompt action to develop new antimicrobial modalities and therapies, it is projected to kill ~10 million people per year by 2050.

Since microorganisms evolve quickly, pathogens have adopted even the last resort antibiotics. This necessitates the urgent discovery of newer agents with a different mode of action than those that have developed AMR while maintaining, and/or improving the efficacy of existing antibiotics. In an eloquent study, scientists developed hemithioindigo (HTI)-based molecular machines capable of specifically killing growing bacteria and antibiotic-tolerant persister cells of deadly bacteria like Methicillin-Resistant Staphylococcus aureus (MRSA) within minutes of activation with visible light, including the elimination of biofilms of S. aureus and Bacillus subtilis in as little as 1 hour after light activation, and without causing any harm to mammalian cells. While these are promising developments, as of today diagnosing infections promptly using prominent diagnostic kits like Acutis Reveal™, multiplex PCR-based tests covering a wide array of pathogens, are the only available measures to identify the pathogen and treat the infections promptly so as to lower the burden of AMR.

Read the full article here

- Acutis team
Fruit flies reveal promising drug candidates for treating cocaine use disorder

The data among people 12 and older showing more than 165 million people in the US using some sort of substances (i.e. tobacco, alcohol, kratom, or an illicit drug) in 2019 suggests that substance use disorder (SUD) is a growing public health problem. Unlike the availability of some medications for opioid use disorder and alcohol use disorder, since we lack an effective medication for stimulant use disorders, including cocaine use disorder, the news that researchers were able to use an innovative computational approach to identify a generic drug that could be repurposed to treat cocaine toxicity is exciting.

By analyzing the gene expression data from post-mortem human brain tissues from 71 individuals, 36 of whom died from a cocaine overdose, and then using the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) L1000 database to identify potential drug candidates, scientists from Emory University were able to identify IBRUTINIB, a drug commonly used to treat cancer, as a potential candidate for treating cocaine toxicity.

They reported that the genes that were highly expressed in the brains of cocaine users were expressed at low levels in neuronal cells when treated with the drug and vice versa.

Read the full article here

- Acutis team
Will there be a COVID winter wave? What scientists say

As the winter is kicking in, scientists are worried about the compelling evidence suggesting for a surge of COVID-19 this autumn and winter. Along with a bigger comeback of RSV and Flu, the emergence of new immune-evading strains of the SARS-CoV-2 Omicron variant, behavior changes, and waning immunity are more likely to push the infection rates higher. Scientists are exploring the factors that might drive a COVID-19 wave and the ways to minimize the effects with the new generation of vaccines and other preventive measures.

For individuals and public health agencies to get well prepared, scientists are digging into basic questions like whether will there be a COVID-19 wave this autumn and winter, are new variants behind rising case numbers, will we see a new Omicron strain this autumn, why are these variants on the rise, how big will autumn–winter waves be, what about the new vaccines, etc. Although evidence hinges towards a potential surge, fortunately, COVID-19 vaccines, both old and new, remain highly effective in preventing severe diseases and death, thus urging for concentrated booster campaigns on those at the highest risk of severe disease, including older and immunocompromised people, who will benefit the most from the added protection.

Read the full article here

- Acutis team
STIs in 2022: emerging and re-emerging outbreaks

Sexually Transmitted Infection (STI) is an infection of the genitourinary system passed from one person to another through sexual contact. The burden of STIs is very high in the US with the CDC estimates of 1 in 5 people (about 20 percent of the U.S. population). If not diagnosed and treated promptly, STIs can lead to bladder problems, damage to organs, reduced life expectancy, infertility in women, and other complications.

Unfortunately, on top of several inherent issues associated with STIs, the COVID-19 pandemic added another complexity leading to low coverage for preventative, diagnostic, and treatment services consequently promoting the resurgence of STIs and the emergence of non-classical STIs globally. Even in developed countries like the US and Canada, where STI surveillance data is available, there is an increase in at least 3 STIs: Syphilis, Gonorrhea, and Chlamydia. The global picture seems grim with reports of a rise in outbreaks of non-classical STIs spread by sexual contacts such as Shigella sonnei, Hepatitis A, Neisseria meningitidis, Zika, and Ebola; and the re-emergence of neglected STIs such as Lymphogranuloma Venereum (LGV). It is more important than ever to use cutting-edge diagnostic tests like Acutis Reveal™ STI to promptly identify the pathogen and treat it appropriately.

Read the full article here

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