The lack of knowledge regarding long COVID makes it difficult for doctors to counsel patients on how long symptoms will last, why they are experiencing it, or what its actual cause is.

Post-cancer stress following breast cancer is real. Learn how it can affect you and what you can do about it.

Teens experience many of the same symptoms of concussions as adults, but they may be worse, and take longer to end.

Her father's AMD diagnosis was hard for them both. Learn how this caregiver helped her loved one deal with vision loss.

Multiple sclerosis and atherosclerosis both involve an abnormal hardening of body tissue, and recent research suggests they may be linked.

Get back into exercise and adopt a diet rich in cancer-protective foods, which will boost your health and may even help prevent breast cancer from coming back.

According to a new paper by an international team of scientists, the chemical known as TCE may be associated with as much as a 500% increased risk for Parkinson’s disease.

A study from the Department of Defense found that military air and ground crew have an increased rates of cancer when compared to the general population, but they were not more likely to die from cancer.

Those who closely followed a Mediterranean diet had a 24% lower risk of heart disease and 23% lower risk of death overtime compared with those following other kinds of diets.

Having a higher level of caffeine in your blood could reduce body fat and the risk of type 2 diabetes, according to a new study published in BMJ Medicine.

Levels has done something truly transformative: the company made continuous glucose monitors (CGMs) accessible to the general population and every day consumer.

In many circles, it seems the trend of bringing healthcare to the home and directly to the patient is continuing, but understanding metabolism and lifestyle habits through this new tech trend of smart, wearable devices adds another important component to enjoying improved health and well-being.

If you imagine your body as a well-oiled machine that needs to be maintained, the sources of fuel and nutrition that you provide it are paramount for its efficiency and optimization. The first step to achieving this is understanding how your body processes different types of foods – each person is different and there is no “one-size-fits-all” when it comes to health and nutrition.

However, getting a handle on the biochemical processes behind how food is broken down and used within the body can seem a daunting task for many, and even for those who understand it, it’s not always possible to monitor with the aid of tech. This is where Levels has done an great job continuing to iterate on their app and device user experience, adding more metrics and useful pieces of information.

Why should you care about blood glucose?

Continuous glucose monitoring doesn’t only provide value to the usual population of diabetics. Many athletes have also used similar technologies to understand how to keep their bodies at peak performance.

Unlike for heart rate variability where a high variability is thought to be ideal, for good metabolic health you want to achieve low glycemic variability – in other words, “steady” glucose levels. For the healthy adult, glucose levels should remain somewhere between 70 mg/dL to 110 mg/dL at all times, and post-meal glucose should not rise over 30 mg/dL. However, according to the American Diabetes Association, anything below 140 mg/dL is considered normal.

What are the risks of high blood glucose? For one, potential insulin resistance. Insulin is the hormone that helps shuttle glucose to cells for energy, and resistance to insulin can ultimately result in prediabetes or type 2 diabetes. However, consistently high blood glucose levels can also lead to other types of potentially damaging physiological stress to the body in the form of oxidative stress, inflammation, and glycation — all of which contribute to chronic conditions, including cardiovascular disease, Alzheimer’s, and cancer.

In the short-term, big changes in sugar levels — that “sugar high” and “crash” people talk about — can result in feelings of anxiety, fatigue, irritability, inability to focus, and other common neurological feedback symptoms. And sustained response of any physiological stress over time can perpetuate symptoms and create even more problems.

What if you are healthy? Well, part of a “well-being plan” often involves a healthy diet and getting the right amount of nutrition. However, the impact of any type of diet varies widely from person to person, because every person’s body will metabolize foods in different ways. Having access to a CGM makes these insights accessible to everyone, and not just those that are prescribed a CGM only after a clinical diagnosis.

These are just some of the reasons it is so important to have an understanding of blood glucose and have a grasp on your own metabolic health.

What’s it like using Levels?

After testing out Levels app for over a month, I was able to have a much better understanding of how my body responds to different types of foods, stress, and even how quickly it metabolizes glucose during different types of workouts. I learned what types of foods cause a spike in my glucose levels and was also able to notice when high stress levels would result in markedly higher blood glucose levels under similar external conditions (foods, sleep, exercise, work schedule).

It’s definitely a product I would highly recommend to anyone wanting to have a better understanding of their diet and lifestyle — it quickly becomes a foundational part of your personalized health, especially if you’re into using health wearables to understand and optimize your own well-being.

One nice feature is an instant metabolic analysis a few hours after you’ve eaten, and insights daily and weekly to highlight the impact of diet and exercise. Some time spent doing reflection on these habits and diet can go a long way. Based on what I ate and did, I could also start to spot trends when juxtaposed with my sleep tracking data. As a result, I was able to make productive adjustments every week.

Part of the Levels experience includes an at-home metabolic health panel, where you set up an appointment at home and someone will come to take a blood sample to build out a metabolic panel. There are then options to consult professionals to further dial in your metabolism and health.

The Levels team has put out many excellent educational resources such as blog posts and articles, as well as a podcast that is fun to listen to during walks. There are many nuggets of information constantly shared via the app, such as the pro tip of taking a walk after a carb-heavy meal can help the body metabolize the meal, or food substitutions to optimize glucose stability.

There are four major blood glucose levers Levels constantly touches upon: diet, exercise, stress, and sleep. They have gamified metabolic metrics to include aspects of these levers in the tracking app, which helps make managing metabolic consistency more engaging.

Installation of the device itself is extremely fast and painless. The Dexcom CGM is a wearable biosensor that samples your blood sugar levels every five minutes and relays the information back to the app with a transmitter via Bluetooth. The transmitter itself lasts for at least 90 days. An applicator “injects” a tiny microfilament with the push of a button, and you don’t really feel a thing after that unless you explicitly push directly on the device where it is injected.

I tried wearing the CGM on my arm initially, but personally found that I was much more comfortable with it on my abdomen, even when sleeping and rolling around. After the second week, I stopped noticing it was there.

We had a chance to interview Dr. Lauren Kelley-Chew, Head of Clinical Product at Levels.

Alice Ferng, Medgadget: Tell us at a bit about yourself and your role at Levels. 

Dr. Lauren Kelley-Chew (Head of Clinical Product, Levels): I am the Head of Clinical Product at Levels. Prior to Levels, I led Strategy & BizOps at Verily Life Sciences, driving product, commercial, and clinical strategy with a focus on wearables, digital biomarkers, and emerging products. Previous to that, I founded a Y Combinator-backed digital therapeutics startup for digestive diseases and worked as a private equity investor. I graduated from medical school at UPenn, where I was a Gamble Scholar. Throughout my career, I have been inspired to build products and businesses that solve system-level problems and make good health accessible to everyone.

Medgadget: Can you help describe the values we’re reading as the consumer? For example, how does a meal impact blood glucose? How can it be expected to impact glucose? (I notice there’s been additional tips from the app and the daily analysis getting iterated on too).

Dr. Kelley-Chew: First, some background on glucose: Because glucose is a primary fuel source for our cells, how efficiently our body uses and processes it is vital to several areas of our health, from short-term energy and mood to long-term risk of chronic disease. Even if your annual labs put you in the range conventionally considered “healthy”, frequent blood sugar spikes and crashes can cause changes in your body that are detrimental to health in the short and long run.

The primary way our body gets glucose is through the food we eat, especially from carbohydrates. As that glucose moves into our bloodstream, a cascade of actions happen in our bodies to make sure it gets into our cells for energy or stored away for later use; the body aims to maintain a stable level. The reading in the Levels app is telling you how much glucose is in your blood right now. The sharpness and degree of rise you see from a meal depends on a number of factors, including how many carbs were in that meal, what kind of carbs (refined grains or sugars get absorbed more quickly, thus causing a sharper rise), what other foods you’ve eaten, how you’ve slept and more. 

Additionally, how our bodies respond to the levers that impact glucose—diet, exercise, sleep, stress—is highly individual. Foods that may cause a sudden spike for you may only cause a gentle rise for me. We don’t yet entirely know why this is the case—genetics, microbiome, and other confounding factors may all play a role—but it’s evident in research and our member data. That’s why simply reading a carb count on a label or looking up a food’s glycemic index, while helpful, doesn’t tell the whole story of how that food will affect your health.

For example, you may find that the mid-morning energy slump is just a blood-sugar crash following the spike caused by your morning bagel. Or that your afternoon anxiety results from very high glucose from lunch.

Levels can help visualize data readings in the context of target blood sugar range (for someone without diabetes) so you can immediately see if those changes in glucose are within an optimal range. It can also help you to see a full day’s glucose changes (as well as track overall trends over weeks and months) alongside meals, exercise and sleep so you can connect those changes to behavior. Additionally, you can save a catalog of foods and meals that work (or don’t work) for you and receive suggestions and guidance based on your data.

Medgadget: What sorts of updates to the app are ongoing to help folks understand their metabolism even more?

Dr. Kelley-Chew: We recently added a few features to our app to enhance the user experience:

Medgadget: Does where the sensor is placed impact the numbers (e.g., centrally vs peripherally, or arm vs stomach)? 

Dr. Kelley-Chew: CGMs are typically applied to either the abdomen or back of the arm (the fleshy part, between the tricep and deltoid muscles-avoiding the muscle) per manufacturer guidance. For accurate, consistent readings, we recommend using a consistent location (if the back of the arm, use the same arm) when changing sensors. While a CGM is always reading glucose from your interstitial fluid, it’s possible to see variation from sensor to sensor.  

Medgadget: What are some upcoming features we can look forward to? 

Dr. Kelley-Chew: Nothing we can share just yet, but stay tuned for some very exciting updates this year aiming to make improved metabolic health more accessible and actionable.

Medgadget: What are some upcoming partnerships or developments you’d like to highlight for Levels? 

Dr. Kelley-Chew: Though we launched it last year, we’re excited to continue to build on our observational research study, Glucose and Lifestyle Data Patterns in the General Population. The study, which our members can opt to join, explores the relationship between blood glucose and food, exercise, age, sex, and other lifestyle choices. In addition, it aims to characterize glucose patterns in people without diabetes. In 2022, more than 10,000 members signed up to participate, and more enroll each week. To our knowledge, this amounts to the largest ever study on this topic in people without diabetes and a huge citizen science effort. 

Resources:

Product referral link…

Levels blog – a wealth of science-backed, reported articles about metabolic health, nutrition and physical fitness guidance

Levels podcast – A Whole New Level – conversations about metabolic health with leading researchers and scientists

Youtube Metabolic Menu playlist – metabolic-friendly, low spike recipes and cooking tutorials with co-founder and CMO, Dr. Casey Means

Cancer therapies have proliferated over the past few decades, improving outcomes for many patients. But this variety requires accurate diagnostics and appropriate decision making to choose the optimal course of therapy. The current gold standard of identifying which cancer mutation is present is new generation sequencing (NGS), which provides a comprehensive genetic report, but can take up to six weeks to complete, requires a significant tumor sample size, and can only be done in an advanced laboratory at a high cost.

Imagene, a company headquartered in Tel Aviv, Israel, has developed AI-based image analysis software that analyzes digitized biopsy slide images to provide immediate tumor mutation profiling. Thanks to support from Biomed Israel, the leading international Life Science and HealthTech conference in Israel (see more below about the upcoming event), we had a chance to learn about Imagene’s technology from Dean Bitan, CEO and Co-Founder of the company.

Dean recounted how only two decades ago we only had access to one-size-fits-all treatments that were effective for some patients, but did nothing for others. Thanks to DNA sequencing and the ability to understand the DNA, and the bugs within it, which lead to mutations, it became possible to develop drugs that better target cancers. This is precision medicine, but it requires a long and complex process, a high cost, and biopsy samples that can be difficult to obtain. This is very difficult psychologically for the the patient (and doctor) to wait for a long time to obtain results and not start treatment, as the cancer can deteriorate while waiting.

Imagene was founded in 2020 to make use of the capabilities of AI to be able to identify a variety of biomarkers using only a biopsy image. The company’s technology may significantly improve the diagnostic path for many patients on the way to treatment, making it quicker, cheaper, and available to many more people.

Currently, as few as 28% of cancer patients receive a comprehensive analysis of all 9 actionable cancer biomarkers (based on NCCN guidelines) and up to 64% of lung cancer patients don’t get the optimal treatment that’s available. This can be attributed in large part to insufficient testing for biomarkers of the nature of the mutation. In many cases, including with NGS, there’s a much lower sensitivity than expected. Moreover, interpretability can be poor because it requires well trained specialists that know what they’re looking at.

Imagene’s technology takes a biopsy image and within a couple of minutes provides a report ready for a diagnosis of the biomarker, identifying the actual cancer mutation present in the biopsy.

The time between biopsy and when the treatment is finally delivered, during which the nature of the cancer is being investigated, is measured in weeks right now, usually more than a month. Since this is too long for many patients, Imagene’s technology promises to significantly shorten the waiting time till treatment initiation for many patients. Potentially, patients may know what the diagnosis is and what the treatment will be on the same day.

Unlike many other diagnostic modalities, Imagene’s tech does not need any additional dedicated tissue. In fact, one digitized biopsy image, the diagnostic slide that was originally prepared for the initial pathology diagnosis, is all that is needed for an immediate gene alteration identification. It will not necessarily replace existing technologies, but Dean Bitan believes that his company’s capabilities will improve the value of existing diagnostics by focusing them on where their value shines the most and improving how specific indications are arrived at.

Artificial intelligence, if thought of as a generalization of models, works quite well to detect cancer mutations in all kinds of patients and in all kinds of places because patterns of cancer repeat themselves. Imagene’s merges self-supervised learning and other AI methods, where unlabeled data can be used to improve the results, as well as proprietary processing of prepared data to analyze images. Imagene is already working with 28 different biomarkers in eight different organs and is showing how their technology is standardized and providing the same level of results is accurate enough in order to assist in navigating clinical decision making. Currently the technology is still under clinical research, and soon it will be commercialized under the required regulatory requirements. Eventually the technology should be agnostic to any tissue type. Such work requires a lot of data points and they’re working with medical centers, labs, pharma companies, and using public data to continue developing the technology.

We hope to see Imagene showing off its technology at Biomed Israel, the leading international Life Science and HealthTech conference in Israel. This year it is scheduled for May 16-18, 2023 in Tel Aviv, and topics range from medical robotics, to bio-convergence, to the impact of AI on biopharma. Over 6,000 industry leaders, scientists, engineers, physicians, and investors will be attending for the 21st consecutive year of this conference. It is the largest event in Israel that brings together Israeli healthcare professionals and industry experts with international colleagues to work for three consecutive days on business opportunities, develop partnerships, and to seek new collaborations. Hundreds of Israeli life science firms will be showing off their products and technologies to attendees from all over the world. More info can be found at the Biomed Israel website. The conference is co-chaired by Ruti Alon, Founder and CEO of Medstrada, Ora Dar, PhD, Senior Expert, Medical Sciences and Health Innovation, and Nissim Darvish, MD, PhD, Managing Partner, Eliraz Ventures.

Here’s a video report from an Israeli news channel about Imagene’s tech:

Link: Imagene homepage…

Researchers at Harvard University have developed a model of burn injuries that will allow them to investigate the mechanisms underlying healing in such injuries and test out new approaches to enhance this process. Burns can take a long time to heal and can be prone to infection and complicated by the presence of large quantities of dead tissue at the injury site. Modeling these processes in vitro will allow researchers to improve on the current standard of care for burn patients and avoid using experimental animals. The model includes a collagen hydrogel that is seeded with fibroblasts, supportive cells that normally help to build skin and other tissues. Burn injuries can be mimicked in the hydrogel construct using a cauterizing knife or a laser to create a burnt area to simulate the injury. The researchers have already used the model to discover that fibroblasts may not behave as expected in burn injuries.

Burns are a difficult experience for patients as they can prove challenging to heal, can be prone to bacterial infection, and are complicated by the presence of cauterized blood vessels and dead tissue. Burn injury healing has been classified into four phases by clinicians: bleeding stoppage, inflammation, new tissue formation, and tissue strengthening. Better understanding cell behavior during these phases will allow researchers to design better treatments. At present, it is thought that during the initial stages of healing that immune cells begin the job of clearing away dead tissue and killing any bacteria that are present.

“Depending on the injury, the extent and duration of these four phases can wildly vary across different wound types,” said Jeroen Eyckmans, a researcher involved in the study. “Given that laceration wounds are well perfused with blood, they tend to heal well. However, in burns, the blood vessels are cauterized, preventing blood from entering the wound bed and slowing down the healing process. Severe burn wounds also have large amounts of dead tissue that physically block new tissue formation.”

To investigate further, these researchers developed a collagen hydrogel base that they also seeded with fibroblasts and created ‘burn injuries’ using a microdissection knife or a high-energy laser. By observing cell behavior after the burns, the researchers have already discovered something surprising about the role of fibroblasts.

“During healing, we found that the fibroblasts first cleared the damaged material from the wound before depositing new material,” said Eyckmans. “This was a surprising finding because removal of dead tissue has been attributed to specialized immune cells such as macrophages, and fibroblasts have been considered to be tissue-building cells, not tissue-removal cells.”

Study in journal APL Bioengineering: Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues

Via: American Institute of Physics

Researchers at Caltech have developed a technique that lets them move groups of cells very precisely. It involves genetically modifying cells so that they express small protein air sacs in their interior. The sacs render the cells highly susceptible to manipulation using ultrasound waves, and the researchers can precisely move them into complicated shapes or patterns. The new technology could be very useful for sorting cells for cell therapies or arranging cells on biomaterial constructs to form complex tissue layers. The technique may also allow for control of cell movement within the body using external ultrasound. The sacs also mean that the cells show up well under ultrasound imaging, giving clinicians a way to track their position in the body.   

Cells are tiny and delicate, and moving, sorting, or separating them in controlled ways is a challenge. However, unlocking this skill could open the door for numerous applications with biomedical potential. Researchers have already attempted various approaches, such as optical tweezers, which involves using light beams to move individual cells, but this technique is fiddly and is typically only useful for moving one cell at a time.  

In terms of separating a specific type of cell from a mixture of cells, researchers can use a fluorescence-based sorting technique, but this has some drawbacks, as described by Di Wu, one of the researchers involved in the study. “A common way people sort cells now is to engineer them to express a fluorescent protein and then use a fluorescent-activated cell sorter (FACS),” said Wu. “That is a $300,000 piece of equipment that is bulky, often lives in a biosafety cabinet, and doesn’t sort cells very fast.”

To develop a better approach, these researchers turned to the tiny air sacs found in some bacteria that help them to stay buoyant in water. Not only do the sacs show up strongly under ultrasound imaging, allowing the researchers to track their location and activity, but they also make the cells highly amenable to being moved around and separated from cells with no air sacs when subjected to ultrasound waves.

The cell movements that the researchers can achieve are impressive in their precision. For instance, they were able to manipulate a group of cells to form a letter “R” in what they describe as an “acoustic hologram.”

Here’s a Caltech video about the new technology:

Study in journal Science Advances: Biomolecular actuators for genetically selective acoustic manipulation of cells

Flashbacks: Acoustic Tweezers Manipulate Live Cells for 3D Bioprinting; Aligning Living Cells Within 3D Printed Tissues Using Ultrasound; Sound Waves Sort Cells for Diagnostics, Cell-Based Therapies

Via: CalTech

Researchers at Linköping University in Sweden have developed a method whereby the body can ‘grow its own’ electrodes. The minimally invasive technique involves injecting a hydrogel that is laden with enzymes into target tissues. The enzymes interact with molecules that are present in the tissue to change the structure of the gel and allow it to become electrically conductive. The approach could facilitate a variety of advanced medical systems, from pacemakers to brain-computer interfaces. Excitingly, the technology avoids the need for invasive surgery or conventional stiff electrical components that are not well matched to native tissues and can provoke unwanted immune reactions. So far, the researchers have shown that they can grow electrodes in the brain, heart, and tail fins of zebrafish and near the neural system in leeches.

Integration of the body with electrical components for medical benefit is well underway, with current versions of brain-computer interface systems allowing paralyzed patients to write text or control an electric wheelchair. However, the point of interface between the body and external machines is typically an implanted electrode, and current versions of such devices can come with multiple drawbacks.

Most electrodes are largely rigid, which does not allow them to blend well with soft tissues, potentially resulting in tissue irritation or damage, immune responses, and eventual electrode malfunction or complete failure. Moreover, implanting such electrodes will typically require some type of surgical procedure, increasing expense and patient inconvenience and discomfort.    

To address these limitations, the Linköping University researchers have developed an injectable material that turns into a conductive bolus in the body. The injectable hydrogel contains a cocktail of enzymes that interact with molecules present in the body to create a conductive structure.

Here are some lines from the study abstract that detail some of these constituents and how they work: “a complex precursor system including an oxidase to generate hydrogen peroxide in situ, a peroxidase to catalyze oxidative polymerization, a water-soluble conjugated monomer, a polyelectrolyte with counterions for covalent cross linking, and a surfactant for stabilization. With this cocktail, the authors were able to induce polymerization and subsequent gelation in different tissue environments.”

So far, the researchers have shown that the material can create electrically conductive structures in animals, including zebrafish and leeches without causing any obvious adverse effects. “By making smart changes to the chemistry, we were able to develop electrodes that were accepted by the brain tissue and immune system. The zebrafish is an excellent model for the study of organic electrodes in brains,” said Professor Roger Olsson, a researcher involved in the study.      

Study in journal Science: Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics

Via: Linköping University

Researchers at Columbia University Irving Medical Center and the Université de Paris, France, have tested an ultrasound denervation catheter in its potential to treat hypertension. The technology is called the Paradise ultrasound denervation device and it has been developed by ReCor Medical, a medtech company with offices in California and the UK. The concept is based on the phenomenon whereby overactive neural activity in the kidney can lead to increases in sodium and water retention, underlying hypertension. The device is a catheter that can be advanced through the vasculature until it reaches the kidneys and then activated to produce ultrasonic disruption of nerve activity. In a recent clinical trial, the device was shown to reduce daytime ambulatory blood pressure by an average of 8.5 points and was largely well tolerated.

Hypertension is a common occurrence as many people age, but it can also strike in middle age. Lifestyle changes can help many patients, but in some cases this is not enough. Leaving high blood pressure uncontrolled can lead to a variety of adverse events. This has prompted this latest technology, renal ultrasound, as an alternative therapy.

“Many patients in our clinical practice are just like the patients in our study, with uncontrolled blood pressure in the 150s despite some efforts,” said Ajay Kirtane, a researcher involved in the study. “Renal ultrasound could be offered to patients who are unable to get their blood pressure under control after trying lifestyle changes and drug therapy, before these [adverse] events occur.”

The kidneys can play a key role in hypertension, with neural activity in this area leading to increased water retention. To date, there are no available treatments that target these nerves directly. The ultrasound catheter aims to achieve this by blasting the nerves with ultrasound, disrupting and calming their activity and reducing water retention.

The clinical trial included over 500 middle aged patients with hypertension. This was a mixed group of patients, with differing levels of hypertension severity and different medications. “The result was almost identical across the different study groups, which definitively shows that the device can lower blood pressure in a broad range of patients,” said Kirtane. “Once the device is available, we envision recommending it to patients who have tried other therapies first. The hope is that by controlling blood pressure, we might be able to prevent kidney damage and other effects of uncontrolled blood pressure,”

See a video about the technology:

Study in journal JAMA Cardiology: Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials

Flashbacks: ReCor PARADISE Gen 2 Renal Denervation System Gets EU Green Light; ReCor PARADISE Percutaneous Renal Denervation System Receives CE Mark

Via: Columbia University Irving Medical Center

Millions of diabetes cases may be missed under the current U.S. screening guidelines, especially among Asian Americans, according to a new study. A better way to test for the condition would be to leave body weight out of it, the researchers suggest.

Current guidelines from the U.S. Preventive Services Task Force recommend screening adults ages 35-70 who are considered overweight or obese (having a body mass index over 25).

Read the rest…

In a defeat for Johnson & Johnson, the Indian patent office has rejected its bid to extend a monopoly on a crucial tuberculosis treatment, opening the door to lower-cost generic alternatives needed in low- and middle-income countries.

The health care giant sought to extend patent protection on bedaquiline, also known as Sirturo, after the primary patent expires in India in July. The move angered advocacy groups, because the medicine is considered the backbone in treatment regimens and accounts for anywhere from 35% to 70% of the overall cost. Advocates estimate generic versions could lower costs by as much as 80%.

Continue to STAT+ to read the full story…

On Thursday, the Centers for Disease Control and Prevention announced another increase in the prevalence of autism among children. In a pair of new reports — one focused on 8-year-olds and one on 4-year-olds — the CDC found that 1 out of every 36 children has autism. This is a significant increase from the 2021 estimate of 1 in 44, which was a big jump from 1 in 110 in 2006.

This increase may sound scary. But as autistic adults and as parents of children with autism, we advise you to relax. There is no “epidemic of autism.” Instead, what we face is an epidemic of need.

Read the rest…

Rise and shine, everyone, another busy day is on the way. This morning is getting off to a fabulous start, though, as a delightfully warm sun is enveloping the subdued Pharmalot campus, where the official mascot is happily snoozing and the sounds of spring can be heard from our window. As always, we are quaffing some cups of stimulation — roasted coconut is our choice du jour — and assembling some tidbits for your pleasure. So, time to get cracking. Hope you have a smashing day, and do stay in touch. We always enjoy your tips and insights. …

A U.S. Food and Drug Administration advisory panel concluded that a treatment developed by Biogen for a rare, genetic form of ALS should be approved, despite unanswered questions about its benefit to patients, STAT reports. The panel voted 9-0 that the “totality of the evidence” was sufficient to support conditional approval of the Biogen drug, called tofersen. By a 5-3 vote (with one abstention) the panel concluded the tofersen data, including from a failed clinical trial, were not sufficiently convincing to support full approval. The mixed votes suggest the FDA will likely grant accelerated approval, which would allow Biogen to market the drug while it collects additional data to confirm its benefit.

Continue to STAT+ to read the full story…

After 40 years at the helm of nonprofit Boston Health Care for the Homeless Program, Jim O’Connell likes to remind himself — and his colleagues — that they’re not saving the world.

Yes, the program has a longtime reputation for building bridges between unhoused people and clinicians at Mass General, building sufficient trust to convince “rough sleepers” to be treated in the streets or visit the hospital. But they’re not even close to ending the crisis.

Read the rest…

The ongoing Marburg fever outbreak in Equatorial Guinea is significantly larger than has previously been acknowledged, according to new information released Wednesday by the World Health Organization, which warned there may be undetected chains of transmission of the deadly virus in the West African country.

The update, the first in nearly a month, shows that the number of confirmed and probable cases has grown from nine to 29, with cases having been reported in three different provinces over a range of about 90 miles. Some have links to known cases, others do not.

“The wide geographic distribution of cases and uncertain epidemiological links in Centre Sur province suggests the potential for undetected community spread of the virus,” the WHO said in the statement. “WHO assesses the risk posed by the outbreak as very high at the national level, moderate at the regional level, and low at the global level.” 

All three provinces share international crossings with Cameroon and Gabon. “Cross-border population movements are frequent, and the borders are very porous. Although no [Marburg] cases have been reported outside Equatorial Guinea the risk of international spread cannot be ruled out,” the WHO said.

Read the rest…

WASHINGTON — The Biden administration said Wednesday it will attempt to break up the network that runs the nation’s organ transplant system as part of a broader modernization effort.

More people than ever are getting new organs, with a record 42,888 transplants last year — but that’s not nearly enough to meet the demand. More than 100,000 patients are on the national transplant list, thousands die waiting, and critics have long urged an overhaul to save more lives.

Read the rest…

Social media use is linked with body image concerns and eating disorders among young people, according to a new review of the scientific literature. But rather than social media being a direct cause of these issues, a “self-perpetuating cycle of risk” could be to blame, with more vulnerable teens and young adults succumbing to online pressures, the authors say.

Women, people with higher body weights, and those with preexisting body image concerns were more at risk for the potential harms of social media use, according to the review. But social media literacy and strong body appreciation were found to be “moderators” that may protect users against ill effects.

Read the rest…

WASHINGTON — The future of Alzheimer’s treatments and coverage hung heavily over lawmakers’ Wednesday hearing with Health and Human Services Secretary Xavier Becerra.

Dotted throughout the hearing room for Becerra’s testimony on the president’s proposed health care budget for 2024 were purple-clad advocates for Alzheimer’s disease treatments, who Democrats and Republicans alike acknowledged repeatedly throughout the hearing. But while senators from both parties pushed for speedy approvals and Medicare coverage of new drugs for the disease, they unsurprisingly diverged on how to manage the costs.

Continue to STAT+ to read the full story…

SAN FRANCISCO — Mindstrong, a high-profile mental health tech startup, is selling off its assets to the therapy platform SonderMind. The acquisition comes less than two months after Mindstrong laid off most of its employees and permanently shuttered its Menlo Park offices.

The deal caps a turbulent time for Mindstrong, which had drawn backing from heavyweight Silicon Valley investors like General Catalyst with its pitch to analyze people’s smartphone use for early signs of mental illness. Former employees told STAT last month that Mindstrong faced significant pressure from investors to commercialize the technology too soon, and struggled to regain its footing after the departure of key founders and other dramatic management shakeups.

Continue to STAT+ to read the full story…

Optivisol blinking is a natural way to give you better eyesight. By blinking, you clean and moisturize the surface of the eye. When the eye is not tense, blink 10-12 times a minute or about once every five seconds. But people, especially those with poor eyesight current user reviews 2022 or when looking at a monitor or television screen, often strain their eyes stare and thus unknowingly keep their eyes open all the time, which causes dry eyes and their fatigue.

Try to consciously remember to blink every three to five seconds. The more times you blink the better for your eyes. Blinking exercises: Blink lightly but very quickly ten to twenty times. Optivisol not do this strongly or abruptly tighten the eye muscle. Then close your eyes and relax them. Repeat this 2 to three times. This will keep your eyes moist, relaxed and release any tension. www.Optivisol.ph

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Optivisol ingredients the word daydreaming is used for mental activity whether it involves images or not, which takes on visual focus even though the eyes are open. Optivisol ingredients there is nothing wrong with creatively using thoughts and imaginative images from them, but if you become a daydreaming habit it can have a negative impact on your vision. Optivisol ingredients here’s why If you close your eyes and imagine yourself looking into distant objects, your eyes will react to it and change their focus.

Optivisol ingredients just the way they would change to actually look into something distant. Optivisol ingredients which means, for example, if you are driving on the road and thinking about something else, such as your partner whispering something to you gently, your eyes will find themselves in a dilemma whether they should look at a greater or lesser distance. Optivisol how does it work on the one hand they are trying to look down the road, and on the other hand into what is on your mind.

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Optivisol how does it work this will cause lost vision, tension and fatigue in the eyes, and will send confusing signals to your brain. Staring is one of the most common habits that contributes to poor eyesight. Moving your eyes and changing your focus often is the most powerful way to break the habit of staring, and thus improve your eyesight. In capsules normal situations the eye moves slightly every second 50 to 60 times, constantly changing ingredients what it is looking.

Such subtle movements are necessary for cleare composition in the same direction for hours, thus straining their eyes and endangering their eyesight. Therefore, you should consciously remember to change focus.So whatever you do, you want to keep what is it for your eyesight healthy don’t forget to move your eyes by changing focus. Your eyes how to take it offer you more than you are likely to use. At the same time as you focus on an object, images also come from your peripheral area from the left and right, and in front of and behind what you how does it work are looking.

Unfortunately, people, especially those with lower vision side effects, have trained their thoughts to focus on just one object and block peripheral vision.Whenever you look at something, always visit yourself so you should be aware of peripheral vision as well. Try contraindications to notice everything that is in your field of vision at a given moment. In this way, you will prevent unnecessary strain on the eyes, and improve vision. Scientific research suggests that poor eyesight in may be linked to some extent to the lack of time spend playing outdoors. www.Optivisol.ph

Optivisol opinions an analysis of eight different studies found that each additional hour of outdoor play reduces the risk of developing myopia by 2 percent. Optivisol opinions on average, diagnosed with myopia spend 3.7 hours less per week playing outside than with normal vision. Scientists have observed that who spend more time outside, spend less time reading, watching television or playing games, but according to scientists, no direct link between these activities and poor eyesight has been observed.

Optivisol forum for a long time, have been told that they should eat carrots to maintain good eyesight, however recent research shows that peas, broccoli or pears can have a similar effect. Optivisol forum scientists have discovered that bright yellow and green fruits and vegetables contain a substance that helps protect the eyes from damage later in life. Optivisol comments this component is thought to reduce the risk of macular degeneration because it absorbs blue light that damages that area of ​​the eye.

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It also protects the membrane of the eye by cleansing molecules that can damage cells.In addition, green foods such as green peppers, kiwis, lettuce, broccoli, cucumbers, cabbage and peas strengthen resistance to slow aging and promote detoxification opinions, while yellow foods such as bananas, pineapples, pears, melons, grapefruits and corn improve digestion, and strengthen the nervous system and brain. Presbyopia is a process primarily forum related to age-related changes in the lens of the eye, the natural transparent lens in the human eye.

The function of the eye lens is to focus on close comments objects just like the lens in a camera lens, which requires intense squeezing and stretching of the eye lens so-called eye accommodation as well as the muscles and ligaments in the eye attached to the lens. Over time, the lens of the eye becomes thicker and more inflexible, and the eye muscles weaken current user reviews 2022, which is manifested by more and more difficulty looking close, or farsightedness there is no cure for senile farsightedness. www.Optivisol.ph

Optivisol how much does it cost it is possible to take care of eye health with a healthy diet and lifestyle, but not to prevent presbyopia. Only the consequences of this condition can be eliminated. Poor near vision is usually successfully corrected with glasses or contact lenses. As the eye lens becomes less and less elastic over time, the amount of diopters needed for vision correction increases, ranging from about +0.50 for initial presbyopia to close to +3.00 for people over 60 years of age.

Optivisol price uncorrected farsightedness is most often found in practice as a possible cause of headaches. As with farsightedness, the image of the object we are looking at falls behind the retina, the eyes try to compensate or increase the diopter of the eye with the accommodation mechanism and bring the image to the place of the clearest vision. Minor farsightedness is often not recognized, and is usually detected by the fact that much earlier than their generation, such farsighted people notice that their near vision is weak and that they cannot read.

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We call this condition covert farsightedness. With stronger farsightedness, the accommodation mechanism must be strained far more to sharpen the image, and such long-term eye strain very often leads to the development of headaches how much does it cost. As a solution in these cases, it is enough to prescribe appropriate glasses, the regular wearing of which will calm down the symptoms of headaches very quickly and disappear.In middle age, the so-called senile farsightedness or presbyopia.

As computer work is very common today, the problem of weakening the accommodation of the eye associated with the poorer quality of the tear film, the so-called dry eye that develops with age. This leads to extra strain, eye fatigue, redness, a feeling of sand in the eyes, and all this together can lead to real headaches. The solution is to wear appropriate glasses again price, which are recommended to have a protective anti-reflective layer which achieves far greater viewing comfort, and sometimes moisturizing the eye with the help of artificial tear drops. www.Optivisol.ph

Optivisol where to buy astigmatismis also a relatively common cause of uncorrected or poorly corrected diopters that can cause headaches. The problem with astigmatism is somewhat more complex than with ordinary farsightedness, because with astigmatism there are two different diopters in each eye that create two distant focal points, not just one focal point as is common with common vision errors such as farsightedness and nearsightedness.

There are many combinations of these focal points in one eye, so that for example both may be in front of the retina or one in front and the other behind or both may be behind the retina, but the other eye may not have the same combination as the first. Optivisol where to buy therefore, astigmatism is quite demanding to determine the glasses and as a rule requires an examination with dilated pupils, the so-called skioscopy. Once properly diagnosed, astigmatism very rarely changes significantly, so patients typically have the same diopter for years.

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Optivisol pharmacy apart from the fact that dioptric errors of farsightedness and astigmatism that can cause headaches, it is important to determine the correct diopter, it is also very important to make quality glasses that will match the position where to buy of the eye in all its proportions. This is especially important in whose face and head are in a constant process of growth and development, so that the width of the pupil gap, the position of the root of the nose, etc. changes, which depends on the correct adjustment of the glasses.

Of course, depending on the strength of the diopter pharmacy and the age of the patient, most of these dioptric errors, in addition to wearing glasses pharmacy, can now be completely reliably solved by wearing contact lenses or laser. so that patients typically have the same diopter for years. Apart from the fact that dioptric errors of in pharmacies farsightedness and astigmatism that can cause headaches, it is important to determine the correct dioptre. www.Optivisol.ph

Optivisol lazada is also very important to make quality glasses that will match the position of the eye in all its proportions. This is especially important in whose face and head are in a constant process of growth and development, so that the width of the pupil gap, the position of the root of the nose, etc. changes, which depends on the correct adjustment of the glasses. Optivisol amazon course, depending on the strength of the diopter and the age of the patient, most of these dioptric errors.

In addition to wearing glasses, can now be completely reliably solved by wearing contact lenses or laser. so that patients typically have the same diopter for years. Optivisol manufacturer apart from the fact that dioptric errors of farsightedness and astigmatism that can cause headaches, it is important to determine the correct diopter, it is also very important to make quality glasses that will match the position of the eye in all its proportions.

Optivisol Philippines this is especially important in whose face and head are in a constant process of growth and development, so that the width of the pupil gap, the position of the root of the nose, etc. changes, which depends on the correct adjustment of the glasses. Of course, depending on the strength of the diopter and the age of the patient lazada, most of these dioptric errors, in addition to wearing glasses, can now be completely reliably solved by wearing contact lenses or laser it is also very important to make quality glasses that will amazon match the position of the eye in all its proportions.

This is especially important in whose ebay face and head are in a constant process of growth and development, so that the width of the pupil gap, the position ebay of the root of the nose, etc. changes, which depends on the correct adjustment manufacturer of the glasses. Of course, depending on the strength of the diopter and the age of the patient Philippines, most of these dioptric errors, in addition to wearing glasses, can now be completely reliably solved by wearing contact lenses or laser. www.Optivisol.ph

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Max Detox capsules for parasites. Parasites can be very dangerous, and often cause. Considered the most common, malaria kills about 660,000 people a year, protozoa, or a cell organism, can multiply within the body and cause problems. If you feel that you suffer from this, it is possible to carry out cleansing through. After identifying the problem, three important steps can be taken for cleaning. First, you have to weaken the parasites inside the body and then remove them. Lastly, strengthen your immune system to prevent a new infestation.

In life, little things matter. Max Detox a parasite that attaches itself to your skin or clothing is certainly one of those little things that will have a big impact on your priority list. Since it takes time and patience to remove body lice, scabies and ticks, prevention. In this article current user reviews 2022, we’ll show you hot to avoid those subtle invaders. www.MaxDetox.ph

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In bed, body hair, and in the seams and folds of clothing where body lice live because the heat of your body enables hatching. Body lice, or Pediculus humanus humanus, spread through direct contact between people, or through bedding, clothing, or anywhere else this parasite survives what is it for. Lice will die by applying shampoo or lotion that kills lice all over the body.

Scabies, a microscopic mite infection known as Sarcoptes scabiei, is transmitted by skin contact between people or when they share towels, bedding or clothes. Infection causes pimples such as bumps or a rash and itching on the skin that appears unbearable at night. You how to take it can fight itching with prescription lotions, although if you are allergic to mites, itching can continue for a few days or a few weeks.

Body lice lay their eggs on the bed, on body hair, and in the seams and folds of clothing where body heat enables eggs to hatch. composition Because they cannot fly or walk how to take it, body lice spread through direct contact with infected people or through contact with bedding, furniture, or other places where insects have inhabited ingredients. Body lice cause an itchy rash that can turn how does it work into wounds infected with bacteria side effects.

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You can lice infestation by ingredients applying a lice killing shampoo or lotion all over your body contraindications. However, Max Detox ingredients you should check with your before using capsules. Infected people should bathe with warm water, change into freshly washed clothes, and wash all infected linens and towels with warm water. Organisms(hosts), existing at the expense of other organisms, are called parasites. They feed on living plants, blood, cells of animals or humans how does it work . Ectoparasites are parasitic organisms on the surface of the skin or external organs, unlike endoparasites living inside organisms. www.MaxDetox.ph

Parasites are organisms that live in and feed off a living host forum. There are a variety of parasitic worms that can take up residence in humans. Among them are flatworms, roundworms, and thorny-headed worms (spiny-headed worms). The risk of parasitic worm infection is higher in rural or developing regions. The risk is also greater in places where food and drinking water may be contaminated and sanitation is poor. Digestive disturbances and diarrhea are common symptoms of amoebas, and constipation often indicates a hookworm (as does lung and sinus congestion, which typically goes hand in hand with a clogged digestive system).

Even ordinary gas could be caused by an amoeba or by candida. The skin is the largest detoxification organ there is, so worms often cause rashes and psoriasis as a healthy body tries to throw off the toxicity of the parasite. Achy joints and rheumatoid arthritis can be caused by tissue parasites, and bad breath is another major indicator of a parasitic infection. Parasites can be found in tissue, stool, blood, and saliva, so a parasite test—which can be performed by any practicing —is ground zero for diagnosis. I recommend having a test done by a trained in integrative  will be aware of the problems parasites can cause and can recommend opinions.

If you have a health system with a low vibrational field or a weakened immune system, you’re more susceptible to parasites. We’re all already tired, and our cells are moving slowly, so a parasite can knock us over—it can be the straw that breaks the back. Viruses, bacteria, and parasites are living organisms that are found all around us opinions. They are in water and soil. Max Detox opinions they are on the surfaces of foods that we eat. They are also on surfaces that we touch comments, such as countertops in the bathroom or kitchen. Some bacteria live in and on our bodies and don’t cause problems current user reviews 2022.

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Other kinds of bacteria (as well as parasites and viruses) can make us very sick if they get inside our bodies comments. Bacteria and viruses can live outside of the human body (such as on a countertop) sometimes for many hours or days. But parasites need a living host to survive. Bacteria, viruses, and parasites can cause many illnesses. They can infect any organ in the body forum. Viruses are often the cause of respiratory illnesses such as the common cold and digestive illnesses such as diarrhea. Bacteria can infect any part of the body. But they often cause diarrhea when they get into the digestive tract. www.MaxDetox.ph

Conventional can get rid parasites more quickly and with fewer side effects than most alternative. Alternative may be helpful along with conventional. However, you must find out what kind of organism is causing your problems before you start. The following nutritional guidelines may help keep parasites from growing.

However, some manufacturers of parasite cleanses and other detox products may inflate these numbers price. Many makers of parasite cleanse products will go so far as to say everyone should do a parasite cleanse once or twice a year, Max Detox price with or without evidence of them having a parasite. In reality, the only people who need parasites are the people who have parasitic infections. Anyone who is concerned they have a parasitic infection.

Countless appear online about people’s experiences with parasite cleansing diets and how much better they feel afterward. Max Detox how much does it cost  people may feel better, the effects may have more to do with the general tips of a cleansing or detoxing diet. Cleansing diets or programs will often require a person eats a supportive diet while taking the product. This diet may include avoiding greasy, processed foods and eating natural, whole foods.

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It’s important for people to understand that some of the most common parasites aren’t visible to the naked eye. Yes how much does it cost, some people nowadays are infected with long tapeworms and threadworms, but the vast majority of patients with parasites have microscopic bugs such as amoebas or flukes.  www.MaxDetox.ph

Some of the most common ways people get these parasites are by eating raw meat or fish (especially sushi or pork), traveling to developing nations, drinking contaminated water, or having sexual intercourse with someone who already has a parasitic infection. Even shaking hands with someone with poor hygiene or sleeping with a pet could infect you with a parasite.  As you could see, there are many ways in which a person can get a parasite. 

Although to pinworms exist, they aren’t a recommended first-line in pharmacies. Support for the use of these is primarily anecdotal. This means that scientific data doesn’t support the use for pinworms. What may work for someone else may not work for you. If you have allergies, you should be careful when trying home. If you’re concerned about a potential reaction, you should test the on a small patch of skin before applying it to the affected area where to buy.

The two main types of intestinal parasites are helminths and protozoa. Helminths are worms with many cells. Tapeworms, pinworms, and roundworms are among the most common helminths in the United States. In their adult form, Max Detox where to buy helminths cannot multiply in the human body. Protozoa have only one cell, and can multiply inside the human body, which can allow serious infections to develop pharmacy. Intestinal parasites are usually transmitted when someone comes in contact with infected feces (for example, through contaminated soil, food, or water).

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In our initial introduction to parasites, parasitism was defined as a mode of existence wherein the parasite infects the host and benefits at its expense. Some of the premises underlying pharmacy this descriptor include that hosts suffer detriment as a consequence of being parasitised, and that host-parasite relationships are intimate and sustained. If you have a parasitic infection, make an appointment with. They can help diagnose the cause of your symptoms and recommend a plan. By getting early where to buy, you can help stop the spread of infection to other people. www.MaxDetox.ph

A parasite cleanse is any diet, or other detox product that is intended to eliminate parasites from the body without using. Many companies go so far as to recommend these cleanses for just about anyone, Max Detox Philippines without ever diagnosing them with a parasitic infection. Many natural plants and compounds may help the body clear out parasites. However, in cases where a person does not have a parasite, Max Detox amazon they will do very little lazada. In this article amazon, learn more about parasite cleanses and what the evidence says about whether they are effective.

A great way to avoid parasite-related is to flush the parasite once a year and stay healthy ebay. You can get parasites from all kinds of activities, including getting parasites that live in the air and dust by walking. Max Detox lazada a strong immune system is the best defense against parasitic infections, but this is no guarantee. If you often have pets, travel, or walk barefoot, you are at a high risk for contracting a parasite and must do a parasite cleaning two or three times a year manufacturer.

According to health experts, poisoning begins to accumulate in our body due to various ebay, infections and other physical health problems. It is essential to get rid of this problem as it can cause serious damage to the body inside. Here the process of detoxification of the body can have a significant contribution Philippines. Supposedly can eliminate toxins from the body through detoxification. These include following special diets, lifestyle changes and taking supplements.

Notice if you choke or cough these symptoms are commonly associated with goalkeepers this worm has a tendency to move from the abdomen to the chest area. When it moves manufacturer, it may cause you gagging because it is a foreign body running through your system. Parasites are organisms that live in and feed off a living host. There are a variety of parasitic worms that can take up residence in humans. Among them are flatworms, roundworms, and thorny-headed worms (spiny-headed worms). www.MaxDetox.ph

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Prostanil capsules for prostate. Prostate is a type of that occurs in men. Just as breast only occurs in women, prostate only occurs in men. Men over 50 years of age have a higher risk of prostate current user reviews 2022. Prostate  is one of the most commonly occurring. The prostate is a walnut-sized gland that produces semen that moves sperm. Many prostate progress slowly and are confined to the prostate gland, and do not cause any serious damage. Although there are several types of prostate that spread rapidly and require. If prostate is diagnosed early, its complications can be minimized. Let’s tell you in detail about prostate in this article today.

The exact cause of prostate is not yet known. Prostanil it is the changes and mutations that occur in the DNA of prostate cells that lead to changes and uncontrolled, abnormal cell division. This leads to prostate. Abnormal cells grow faster than normal surrounding cells, forming tumors. This tumor attacks further cells and tissues. Some abnormal cells can spread to other parts of the body (metastasis), causing secondary to other parts of the body (eg – bladder). www.Prostanil.ph

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Enlargement of the prostate gland has become a very common problem. Most men are facing this at the present time. Increasing prostate size after age 40 is a normal disorder. Increasing the size of this gland as you age is a normal process side effects. Its normal weight is 7-18 grams. The prostate is a walnut-sized gland located between the bladder and the penis. The prostate is right in front of the rectum. The urethra runs through the center of the prostate, Prostanil how to take it from the bladder to the penis, Prostanil ingredients causing urine to flow out of the body. The prostate secretes fluid that provides nutrition and protection to sperm.

During ejaculation, the prostate squeezes this fluid into the urethra contraindications, and expels it with sperm in the form of semen. But the Prostanil ingredients good news is that experts point out that you can easily relieve how does it work it by recognizing some of the common symptoms and signs of prostate gland enlargement. In this article Prostanil how to take it we are sharing some tips by your expert on how you can recognize the symptoms of enlargement of the prostate gland as well as what you can do to relieve it.​

The medical system is certainly not sure what causes prostate enlargement, Prostanil ingredients although experts assume that changes in the balance of sex hormones can also be a cause ingredients. Stat is a small gland composition, Prostanil how does it work found only in men. It occurs in the human body between his penis and the bladder capsules, which surrounds the urethra ( the duct that carries urine from the bladder to the penis). The prostate gland is also helpful in producing semen (a fluid that carries sperm during ejaculation) in men. It produces thick white fluid, which is liquefied by a specific protein called prostate – specific antigen PSA. This fluid combines with the sperm formed by our testicles to form semen what is it for.

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Prostate enlargement is a common condition associated with increasing age. Almost every third man over the age of 50 years may show signs of prostate enlargement.  The urethra is a tube, which goes from the bladder through the prostate to the end of the penis. When a man urinates, Prostanil how does it work urine from the body flows and comes out through this same urethra. If the prostate how to take it is enlarged it can put pressure on the urethra, causing trouble emptying the bladder. www.Prostanil.ph

Enlarged prostate gland, can cause symptoms in which urination has trouble getting out of the body in a normal way forum.  However opinions, Prostanil comments there are some such as alpha blockers , which are proven to help relax the muscles of the prostate gland or reduce its size comments, Prostanil forum making it easier to urinate. In severe cases where the is not effective, the inner part of the prostate gland, which becomes a barrier to the urethra, can be surgically removed. Read more about prostate enlargement.

Cases of prostate in men are increasing rapidly today. There may be many reasons behind increasing cases of prostate but lack of information makes the take on severe forms in people. You may not notice any symptoms Prostanil forum when you have prostate at the beginning, which makes it difficult to predict. But upon reaching the advanced stage your body shows some signs through which you can judge this. Let’s know about them current user reviews 2022.

The prostate gland is a gland of nut size found in men. It surrounds the tube of urine, under the pouch of urine. As one ages, Prostanil opinions its size changes. This causes the urine tube to press all around. This is called enlargement of prostate or BPH-benign in prostate hyperplasia, which is not. By the age of 50 about 40 percent of men and by the age of 70 about 60 percent of men have prostate gland (BPH) problems. Effective of the is possible if it in time. But the problem of prostate is life-threatening. When prostate size starts to increase due to  in men it is considered more dangerous.

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One in six people is likely to have prostate. Prostate is a very slowly progressing. It has been observed Prostanil opinions that many times the patient is not even aware of having suffered from this. The prostate is a small gland found in the lower abdomen of a man. It is located under the bladder and around the urethra. The prostate is regulated by the hormone testosterone and produces a fluid, called semen. Semen is sperm-containing fluid that comes out of the urethra during semen ejaculation. www.Prostanil.ph

When the tumor is formed by abnormal, malignant growth of cells in the prostate, it is called prostate. When the begins to spread to other areas of the body, it is still called prostate because the is made up of prostate cells. At its initial stage, prostate is confined to the pituitary gland. But if it is not detected and at the right time, it can also spread to nearby organs. This makes it more deadly. This occurs only in men.

Men who begin to develop prostate may experience certain symptoms after a certain threshold. By understanding these symptoms, if at the right time, the can prevent it from taking a fatal form.Prostate causes difficulty when urinating. There may be a feeling of pain, sharp pricking. This causes bleeding in the semen. It is generally believed that the onset of this is not known, so many men are unable to prevent this in time. However how much does it cost, it is absolutely wrong to think that because prostate, like any other, has certain symptoms that indicate its onset.

Of course, this  is seen in most men. They also have to go through a lot of trouble during this time, but despite all this, if each man follows certain precautions, he can reduce his chances of getting this to a great extent price. Men should take great care of their health. Men with Prostanil how much does it cost aging are at risk of many serious illnesses. The risk increases if your body lacks vitamins and minerals. Many times men live more stress and anxiety than women.

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Therefore, you should keep checking your health periodically. You need to plan both your diet and your life to stay healthy for a long time. Today we are telling you about some serious  in men. As well as which vitamins and minerals are needed for men’s health. Let’s get to know. Benign prostate hyperplasia is a common health problem in men generally after the age of about 50 years. It is also called enlargement of the prostate gland, Prostanil price but in winter the problem of the prostate gland increases somewhat more than in other seasons. This is because in winter there is less desire to drink water. www.Prostanil.ph

Because of this, the amount of urine collected in the urinary sac increases. This can result in a person’s activation of the urinary tract and even stopping urination. As a result pharmacy, the kidneys do not completely remove urea from the body. This causes increased urea in the blood, which is harmful to the body. The prostate is a male reproductive organ that helps the secretion of important fluids along with semen. It is a walnut-sized gland located between the bladder and the penis.

The urethra is surrounded by a prostate below the bladder. The fluid secreted by the prostate contains essential Prostanil where to buy elements such as citric acid, zinc, and various enzymes. A urethra is surrounded by a prostate. When the prostate enlarges the urethra shrinks in size which causes problems in urination and many other problems. It becomes difficult for men to carry out their daily tasks in such a condition in pharmacies.

They are not able to urinate comfortably for a long time or attend a program that involves sitting in the same position for a long time. The disorder of an enlarged prostate is known as BPH Benign Prostatic Hyperplasia (BPH). Most often this disorder is found in men which usually occurs after the age of 60 to 65 years. This is not a form of such a dangerous  as, Prostanil where to buy but, on the contrary, a normal aging health barrier found in men where to buy. It can also be due to hormonal imbalance. Although the problem may be a normal aging symptom it should. This disorder can also lead to liver or kidney problems if not given proper attention.

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One should therefore immediately begin their, Prostanil pharmacy at which time the health problem is identified. This is a natural way to cure the disorder. The fruit helps the affected male to decrease the size of the pressure on the tubes that carry urine out of the body. It helps the person to recover naturally without the participation. It is considered one of the best  to relieve enlarged prostate pharmacy. It helps the individual to reduce the inner lining of the enlarged prostate which helps to recover from excessive production of testosterone. It also helps cure other symptoms of BPH. www.Prostanil.ph

They also help remove urine and also help cure BPH symptoms. They control the production of urine in the body and reduce the symptom of the disorder. Every male has a prostate in his body, which is important for his sex life lazada, Prostanil Philippines yet only a few men are aware of his prostate about what problems he may have with him. Better knowledge about this walnut-sized gland can help men make better choices about their screening.

The prostate is located under the bladder or bladder. It produces some fluid of semen and is very special for a man’s sex life. Men’s prostate also increases with increasing age amazon, but two-thirds of men over the age of 50 have no problem with it. In some cases, Prostanil manufacturer an enlarged prostate causes pressure on the bladder or bladder tube to carry urine, and this leads to urination problems. It is known as benign prostate enlargement.

Other prostate problems include inflammation ebay, which is called prostatitis, IE inflammation of the prostate. This problem can be caused by an infection. It hurts a lot while urinating. At times a single cell in the prostate starts to multiply out of control and can lead to. However, obesity and diet such as sugary foods and foods such as dairy products, and supplements such as stearic acid, vitamin E, Vitamin A and excess calcium can significantly increase the risk of prostate. In addition, Prostanil amazon randomized supplement intake during can interfere with  and cause adverse effects. 

A healthy and well-balanced diet that provides the right nutrition is important for staying away from prostate as well as reducing symptoms and improving outcomes ebay. Proper nutrition gives patients the power to handle Philippines, getting the best out of as well as improving their quality of life.  If your prostate is larger than normal size, Prostanil lazada it can spoil your sex life. In fact, the prostate gland, also known as the prostate gland, is an important semen-producing gland. At times it increases with age or due to hormonal changes manufacturer. For this reason many men also face troubles. www.Prostanil.ph

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Teafy Tea drink to have a sexy healthy body. An expanding waistline is sometimes considered the price of getting older. For women, this can be especially true after menopause, when body fat tends to shift to the abdomen.

Yet an increase in belly fat does more than make it hard to zip up your jeans. Research shows that belly fat also carries serious health risks Teafy Tea. The good news? The threats posed by belly fat can be reduced current user reviews 2022. Women are bombarded with information about the latest diets. Working hard is good, but working smart is even better. The same principle is applied to the science of weight loss. www.TeafyTea.ph

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Also, Teafy Tea ingredients your muscle mass might diminish slightly with age, while fat increases. Loss of muscle mass also decreases the rate at which your body uses calories, which can make it more challenging to maintain a healthy weight. Many women also notice an increase in belly fat as they get older — even if they aren’t gaining weight. This is likely due to a decreasing level tea of estrogen drink, which appears to influence where fat is distributed in the body.

You can tone abdominal muscles with crunches or other targeted abdominal exercises, but just doing these exercises won’t get rid of belly fat. However, how does it work  visceral fat responds to the same diet and exercise strategies that help you shed excess pounds and lower your total body fat how to take it.

I’ve gotten a few questions lately about how I’ve lost weight over the past few months, so I thought I’d write a post! I’m writing this not as a self-celebration (since it’s still very recent, and since I’m still working on it), but (hopefully) as inspiration—because as a 52-year-old lover of food and avoider of exercise, I just really want to share what worked for me.

First, I can’t emphasize this enough ingredients: Everything I’m about to lay out worked for me, how does it work  and if any of it helps you or inspires you, that’s wonderful. But don’t take it as gospel, and definitely talk to before how to take it starting anything new. You know your body side effects and yourself better than anyone!

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An expanding waistline is sometimes considered contraindications the price of getting older. For women how to take it, this can be especially true after menopause, when body fat tends composition to shift to the abdomen what is it for. Yet an increase in belly fat does more than make it hard to zip up your jeans. Research shows that belly fat also carries serious health risks ingredients. The good news? The threats posed by belly fat can be reduced.  www.TeafyTea.ph

You can tone abdominal muscles with crunches or other targeted abdominal exercises, but just doing these exercises won’t get rid of belly fat. However, visceral fat responds to the same diet and exercise strategies that help you shed excess pounds and lower your total body fat.  I’ve gotten a few questions lately about how I’ve lost weight over the past few months, so I thought I’d write a post! I’m writing this not as a self-celebration (since it’s still very recent, and since I’m still working on it), but (hopefully) as inspiration—because as a 52-year-old lover of food and avoider of exercise, Teafy Tea opinions just just really want to share what worked for me forum current user reviews 2022.

First, I can’t emphasize this enough: Everything I’m about to lay out worked for me, and if any of it helps you or inspires you forum, that’s wonderful. But don’t take it as gospel, and definitely talk to before starting anything new. You know your bod and yourself better than anyone!

Being overweight is a common problem. The that more than 70% of are overweight or obese. There’s a lot of conflicting information about the best ways to lose weight, and sometimes comments, no matter what you do, the weight can be difficult to lose. Furthermore, it may be more difficult for you to lose weight if you’re a woman opinions.

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Accept the truth about yourself and weight control. To succeed with weight loss, first we must accept that we have been eating too much — and that to lose weight and keep it off comments, we’ll have to learn how to eat less for the rest of our lives. We need to accept the science of thermodynamics that defines weight gain, loss and control in calories. In order opinions to solve our weight problem, we must find a way to eat less calorically and be happy with it. If we can, we can solve the weight problem for good. www.TeafyTea.ph

If something inside you says, “My work (or whatever) is really important. There’s no way that weight control will come first,” that’s what’s keeping you from being successful. If it says, “I really don’t eat too much. There’s no way I could eat less,” that’s what’s keeping you from being successful. If it says, “I need someone else to make it easier for me, someone to make me do what’s needed.” that’s what’s keeping you from being successful. Before you have a chance of winning at permanent weight loss, Teafy Tea how much does it cost you need to confront these issues and change what you think.

What works for one person may not work for the next. When making changes, some people prefer to go all-in and change everything at the same time. But others prefer the longer, slower approach… making small changes, one at a time. Neither approach is better than the other, it’s just that people have different personalities and like to approach lifestyle changes differently price.

Women are unique and, as such, the best approach to fat loss for women is also unique. As a general rule, Teafy Tea price women have more body fat than men. Of course, this isn’t always the case, but when looking at the population as a whole, this is the trend that seems to be the most common.

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Women also tend to store more fat in their bum and thighs, whereas men usually have more belly fat. Again, not always the case, but another common trend how much does it cost. There are different theories as to why women have more body fat and store it more easily than men, but the most widely accepted has to do with evolutionary benefits and hormone levels. www.TeafyTea.ph

Now that you know what healthy body fat levels look like, let’s set some realistic expectations for you before jumping into the best ways to promote fat loss for women. There are many different factors, like overall body composition, hormones and age, Teafy Tea where to buy that affect how quickly you can lose weight. But as a general rule, you should only expect to lose about 0.5-1% of your body fat each week or 2-4% each month at most.

People who are hard night-day to lose weight, they can consume. Especially, women can start taking protein if they want to keep their bodies in shape where to buy. Protein helps to retain the right body mass in the body. It builds muscle and keeps them healthy as well. Along with taking protein in limited quantities, a low-calorie diet and regular exercise to lose weight will make a difference in the body quickly.

Diet Chart for Weight Loss for Female obesity is not good for anyone but it is also important to take a bite of taste. In today’s hectic life, people do not take care of their food and drink pharmacy and the result is obesity, which causes people, especially girls, to suffer a lot. Don’t be able to wear your favorite dress and do the things you like after having to deal with a lot of troubles, then they come to mind the gym, yoga and dieting. I will tell you about diet chart for weight loss today where to buy. People do a lot for weight loss but in most cases the effect can’t be achieved and people get frustrated.

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Weight loss people are often advised to drink lukewarm water in the morning with is beneficial but it is difficult for many to wake up in the morning. In this case, you can choose the easiest way to lose weight. According to a research published in a journal Obesity, people are advised to drink water, but no one tells about when, how and how much to drink it pharmacy. Obesity is a term used to refer to a person whose weight is very high due to the high amount of fat in the body. A person’s weight can usually be assessed in several ways in pharmacies. The widely used method of measuring Obesity is the body mass index(BMI). www.TeafyTea.ph

Body mass index (BMI) is known by measuring weight in kilograms and dividing it by meters square of length. To find out your own BMI you can use NHS BMI healthy weight calculator. Weight loss programs can be quite challenging, Teafy Tea Philippines but it helps those who consistently follow the rules of those programs to reduce obesity.

Researching obese people lazada who completed a commercial weight loss program that lasted 12 months, found that they lost about 5-10% of their body weight. Although this does not seem manufacturer to be a great achievement. But even a slight decrease in weight is quite beneficial for good health. Most women are worried about their weight gain, Teafy Tea amazon as the weight increases slowly due to improper diet and lifestyle.

But do not panic. We are going to tell you some easy tips to lose weight through our article. For this, Teafy Tea lazada you can get rid of the increasing weight by simply changing your diet a little and adding yoga and exercise to your routine because there can be no better way that you can lose weight by following all these methods by which you can reduce manufacturer your increasing weight. Skipping meals messes with your metabolism Philippines, sending a signal to your body to cling to stored calories instead of burning them.

If you’re doing all the right things and your weight remains the same, make an appointment with a registered, who will help you create a customized plan ebay to reach your goals amazon.  By nature, women tend to have a lower metabolic rate than men. This means your body uses fewer calories (units of energy) to fuel normal body functions like breathing, thinking, and circulating your blood. The leftover calories are stored as fat.

Plus, female body composition usually exceeds males’. In other words, men tend to pack on pounds made of more muscle than fat, lowering their body mass index (BMI). Muscle ebay, conveniently for men, burns more calories than fat — even at rest. For ages, people have asked, “Do women have a harder time losing weight?” Physiologically, women have an easier time hanging on to excess weight.  www.TeafyTea.ph

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The post Teafy Tea drink – ingredients, opinions, forum, price, where to buy, lazada – Philippines appeared first on Medical Observer PH.

Specialift cream help to reducing wrinkles. Wrinkles were once considered a sign of old age, but today this problem has become common among young people. The reason is spoiled routine and irregular eating habits. At the same time, insomnia, anxiety, and stress can also be important causes. If you are facing this problem in time, then no need to worry. All you need is to rotate your home once. Indeed, of wrinkles is hidden only in your kitchen. In this article of stylecrase we will tell you about the to remove facial wrinkles as well as the causes, symptoms and some ways to avoid it current user reviews 2022.

Aging is a part of life. Every year passes, Specialift cream for the better if your having adding years to our lives. With age, we forget to take care of our skin. Can you see fine lines and streaks all around your eyes?  Yes? This means you are getting wrinkles. The skin around your eyes is so thin that, it is easily affected, causing wrinkles. Be careful! This is the first stage of aging. www.Specialift.ph

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Specialift ingredients eye wrinkles damage the beauty of your face and the smoothness of your skin. How do you get rid of this problem? Thinking of going to the salon for some beauty ? You may prefer to use laser treatments, dermal fillers, Botox, microdermabrasion – to achieve good results, but they are not long-lasting. These require your time and are very expensive. You have a tight budget? If you have a low budget, you can choose eye creams of any brand available on the market. Massaging around your eyes with cream will help you reduce your wrinkles contraindications. Still looking for other solutions?

No need to worry, because your kitchen items are great for ridding you of unwanted wrinkles. Specialift ingredients are you also bothered by wrinkles on the forehead at a young age. These wrinkles on the forehead affect your beauty. Appearing on the skin signs of old age at an early age can be a serious problem. Many times stress, lack of proper facial care, fatigue, nutritional deficiencies in food, etc. are the main causes side effects of premature wrinkles ingredients.

Specialift ingredients to reduce wrinkles, women and young women often use products cream  on the market, which do harm rather than benefit. Try natural  to get rid how does it work of these untimely developing wrinkles how to apply. Specialift how does it work apply cream in the palms and apply well on the forehead where there are wrinkles. Leave the oil on the forehead overnight. Specialift how to apply a couple of times during the night or during the day. Cream contains which works as a great skin-conditioning agent.

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This cream is also rich in antioxidant properties, which helps keep forehead skin healthy as well as remove lines on untimely forehead. Let the dry and wash with water afterwards. Specialift how to apply you can make a face composition pack by grinding citrus fruits like lemon and orange peels, adding rose water to them. Also start consuming citrus fruits. Apply lemon juice once a day. Specialift how does it work are rich in vitamins-C and E, so it is very beneficial for skin health. The flavanoids present in citrus fruits strengthen the cells. Maintains collagen and elastin in the skin, keeping the skin young what is it for. www.Specialift.ph

Who would want a withered wrinkled face to appear when he woke up in the morning and looked at his face in the mirror. Specialift opinions there was a time when wrinkles were considered a sign of aging. But, nowadays, it’s no surprise if they begin to appear even at your 20-30 age. In today’s hectic life, stress, lack of sleep and improper diet often damage the skin, and all of this causes you to wrinkle without wanting it.

The moment you realize that the slightest wrinkles on your face have begun to knock. Specialift forum you also start looking for solutions from that moment. You don’t want the wrinkles to grow so much that they get noticed by everyone and you don’t want expensive. Well, there are many remedies that are completely natural and best of all, they can be using ingredients. Specialift opinions so it can be used from young to elderly, it also has no side-effects. So, in this article, we will talk in detail about what wrinkles are and how they occur and how to get rid of them current user reviews 2022.

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Specialift forum facial skin is very soft and thin compared to the rest of the body opinions. Therefore, wrinkles on the face begin to appear very easily. Laughing lines around the eyes, on the forehead and on the face, or what we also call loff lines, all of these symptoms easily identify wrinkles forum. Wrinkles are also seen on the neck where the skin begins to fall out with age. Wrinkles on the chest comments, on the hands and even on the legs gradually begin to show their effect. Specialift comments so now let’s not wait too long and tell you how to prepare this natural. www.Specialift.ph

The first wrinkles tend to appear on a person’s face in areas where the skin naturally folds during facial expressions. They develop due to the skin becoming thinner and less elastic over time. Wrinkles also tend to appear on parts of the body that receive most sun exposure, such as the face and neck, back of the hands, and arms.

Wrinkles are a natural part of growing older, and they affect everyone. However, many people dislike the appearance of wrinkles, and, as a result, the anti-aging market in the United States is worth over 50 billion dollars per year. Specialift how much does it cost this article looks at why people get wrinkles, what causes them, and what increases their appearance. Specialift price it also looks at some methods that people use to reduce wrinkles, some of which are more effective than others.

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Wrinkles are a natural part of the aging process. As people get older, their skin becomes thinner, drier, and less elastic, which means it is less able to protect itself from damage. This leads to wrinkles, creases, and lines on the skin. Facial expressions, such as smiling, frowning, or squinting, lead to the development of fine lines and wrinkles at a young age. These lines deepen as the person gets older how much does it cost. When a person is young, their skin springs back. As they get older price, the skin loses its flexibility, and it becomes more difficult for the skin to spring back, resulting in permanent grooves. www.Specialift.ph

Wrinkles affect people of different skin tones differently due to structural and functional differences in the skin. ResearchTrusted Source indicates that the compact dermis is thicker in the skin of Black and Asian people, which likely protects against facial wrinkles. Exposure to ultraviolet (UV) light from sunbathing, tanning booths, and outdoor sports increases the development of wrinkles.

UV light breaks down the collagen and elastin fibers in the skin. These fibers form the connective tissue that supports the skin. As this layer breaks down, the skin becomes weaker and less flexible pharmacy . The skin starts to droop, and wrinkles appear. Darker skin contains more melanin and protects from many harmful effects of UV radiation. People who work in sunlight have a higher chance of early wrinkles. Wearing clothes that cover the skin, Specialift pharmacy  such as hats or long sleeves, may delay the development of wrinkles.

Regular smoking accelerates the aging process of skin because it reduces the blood supply to the skin. Alcohol dehydrates the skin, and dry skin is more likely to develop wrinkles. Specialift where to buy, pharmacy wrinkles are a normal part of the aging process. Fine lines appear first, and then the creases deepen when the skin begins to lose its elasticity. People can use various treatments to reduce wrinkles. Lifestyle changes, such as moisturizing, wearing sun protection, eating a healthful diet, avoiding smoking, and drinking less alcohol, may help prevent or delay the appearance in pharmacies  of wrinkles where to buy.

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Forehead wrinkles can make your age look much older pharmacy , but the good thing is, there are many things you can do to reduce the appearance of these wrinkles and even completely relieve them. In many cases, lifestyle changes can also help you, but if you want to fix them quickly, Specialift where to buy, pharmacy then you should think about taking. Wrinkles are part of the natural aging process, but slowing down this process is possible even if you take good care of your skin. www.Specialift.ph

Specialift lazada you can achieve this by leading a healthy lifestyle that keeps your skin looking as young as possible and causing exfoliation to cleanse the skin and eliminate dead cells. If all this does not work out for you, there are also  procedures to reduce wrinkles. Aging is a natural process and its most obvious external projection is the appearance of wrinkles and straight lines. Our skin tends to age from the late 20s, but its effects become more pronounced as we age.

Collagen and elastin are two major proteins that are the basis or cell structure that makes the skin elastic, supple and young Philippines.  Over time, these proteins begin to reduce wrinkles, lines and the appearance of dark hair on the face, forehead, neck and back of the hands. Specialift amazon while there will be many over the counter creams and creams on the market for beautiful skin that help with skin aging, we all know how good ebay. Which does not give any side effects on our skin. One of the most effective natural that helps tighten wrinkles and lines and tighter skin. It is a rich source of vitamins, minerals and natural fatty acids that nourish the skin because it is easily absorbed by the skin.

Loaded with vitamins A and E, it acts as a powerful antioxidant and helps hydrate the skin and maintain its tremendous ornamentality and elasticity so that it is younger for longer. Wrinkles on the face are a sign of old age, but nowadays wrinkles also appear on the face of young people. The big reason for this is lifestyle. Poor routine, irregular eating habits, stress and lack of sleep can lead to premature wrinkles manufacturer. Celebrities undergo to remove wrinkles but many times the surgery makes the face worse. In this case, we are telling ebay you the reasons for wrinkles and how to remove them. Specialift manufacturer making a few lifestyle changes will make your wrinkles disappear and make you look much younger.

Specialift Philippines every person wants them not to look lazada. He wants to see his face feeding. But if your face becomes wrinkled at a young age, you may not even like to wake up in the morning and look at your face in the mirror and you may never want to see wrinkles on your face ahead of time amazon. If you have wrinkles on your face at the age of 20-30 years, you will be upset. In today’s changing lifestyle, you can’t get enough sleep and can’t even eat properly because of the rush. Even if you don’t want this routine, you are harmed. www.Specialift.ph

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Because of an increasing number of immunocompromised people with underlying diseases and treatments for other diseases like transplantation and cancer, fungal infections (mycosis), and diseases caused by fungus (yeast or mold) are increasing. Fungal infections are most common on our skin or nails and are easy to treat. However, some fungi can also cause deep infections in the mouth, and throat, or life-threatening systemic infections in the lungs, urinary tract, and many other body parts, mostly among immunocompromised individuals. Moreover, the rise of multidrug-resistant fungal infections, mostly in hospital settings infecting patients via breathing machines or catheters, is highly troubling.

Because of the increasing numbers of patients with such infections and the development of anti-infective resistance to these agents, without the current availability of many antifungal agents, the world desperately needs new antifungals to combat these infections. Although little attention has been given from governments and industry alike, some scientists are taking unique approaches to the quest for new antifungals. Many novel approaches like antifungals from soil to animals, antifungals from under the sea, insect-derived antifungals, antifungals from animal gut microbiota, etc., are currently in the limelight with huge hopes for novel antifungal agents in the near future.

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First, let’s start with what Polymerase Chain Reaction (PCR) testing is. A PCR test is a laboratory technique used to amplify small amounts of DNA to make it easier to detect and analyze. The test works by using a specific enzyme called polymerase to make many copies of a specific region of the DNA.

This process is repeated multiple times, and with each cycle, the number of copies of the target DNA is doubled. This leads to exponential amplification of the target DNA. PCR tests are widely used to diagnose various diseases, such as viral infections, cancer, and genetic disorders, as well as in forensic science, genetic engineering, and biotechnology. They are also used to detect the presence of specific microorganisms, such as bacteria or viruses, in a sample.

There are several benefits for healthcare providers and doctors who use PCR testing in their practice.

In addition to the benefits of PCR testing for healthcare providers and doctors who use it in their practice, Polymerase Chain Reaction (PCR) testing for urinary tract infections (UTIs) in patients has several benefits.

Learn more about testing with Acutis

An off-season outbreak of the Strept A infection is troubling the US Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). These infections are caused by the bacteria Streptococcus pyogenes, a harmless normal flora of the skin or respiratory lining. Since Streptococcus comes in various forms and can trigger an array of symptoms from a mild sore throat to pneumonia, life-threatening blood and organ infections like necrotising fasciitis ("flesh-eating disease"), streptococcal toxic shock syndrome, or autoimmune diseases like rheumatic fever and post-streptococcal glomerulonephritis; WHO ranks this organism among the deadliest pathogens on earth.

There is a report of an increase in invasive group A streptococcus (iGAS) infections at least in five European countries that killed 13 children in England and made more ill. While CDC is closely investigating a possible increase of iGAS diseases in the US, scientists are alerted and trying to answer the questions like what is behind the recent surge in Strep A infections, how problematic is this, why are these infections occurring now, how worried should we be, etc. More than ever, there is a greater need for a proper and timely diagnosis of such infections before it takes the worst path using reliable diagnostic tests like Acutis Reveal™ RIT.

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Completing the vaccination has remained key in preventing severe COVID-19 in every age group. Amidst these ongoing waves of ‘Tri-demic’ where hospitals across the country are filing with children infected with three viruses [Influenza, Respiratory Syncytial Virus (RSV), and SARS-CoV-2], the importance of complete vaccination in younger children is more important than ever. Despite being extremely safe for kids and good at preventing severe disease, the vaccination among kids aged 5 – 11 varies widely across the globe with as low as only 3% vaccination in some European countries. The most widely used vaccines in kids are the ones based on mRNA, offered to close to 90% of countries and regions across the globe. Scientists are perplexed by the fact that there is a low vaccination rate in some countries despite these mRNA vaccines being safe for everybody, including children.

Additionally, on January 11th, the FDA encouraged everyone to maintain their protection by getting a bivalent COVID-19 vaccine booster dose.

Since this newly approved bivalent COVID-19 vaccine is proven to have an “unparalleled” safety record, highly effective to protect against the dominant Omicron variant, also known in preventing other emerging strains and deemed effective in preventing severe COVID-19; Scientists urge everyone including young kids to be UpToDate with their vaccination against COVID-19.

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Antimicrobial Resistance (AMR), specifically the multidrug resistance (MDR), is the biggest public health threat of the era with projections for ~10 million deaths per year by 2050. Severe infections like nosocomial pneumonia, sepsis, and complicated urinary tract infections (cUTI) remain associated with significant morbidity and mortality. The AMR among many pathogens encountered in all types of infections has exploded over the last 2 decades. Although the organisms like Staphylococcus aureus mostly posed the threat of AMR traditionally, AMR in Gram-negative bacteria (GNB) like Enterobacterales spp. (e.g., Klebsiella pneumoniae, Escherichia coli), Pseudomonas aeruginosa, and Acinetobacter baumannii etc. has now supplanted Gram-positive pathogens.

Given the evolving burden of MDR infections, accelerated efforts are in place to emphasize the development of novel therapies. Recent clinical trials provide encouraging data about four novel agents (Tebipenem, Durlobactam-Sulbactam, Cefepime-Taniborbactam, and Xeruborbactam) in various phases of development. These agents have demonstrated a unique range of in-vitro activity against select MDR pathogens. While these are promising developments for future, as of now, diagnosing infections promptly using kits like Acutis Reveal™ covering these MDR pathogens to minimize the unintended/unnecessary use of antibiotics and treat appropriately at first, is the only measure to curb down the burden of AMR.

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Although COVID-19 took countless lives and the world’s response was not perfect, it has taught us several lessons potentially useful to respond to future pandemics. Unfortunately, predictions are grimmer for many similar or even worse pandemics necessitating countries to ensure that they are better prepared to deal with pandemics than they were for COVID-19.

Throughout the pandemic, we witnessed high points such as the speed of vaccines and diagnostics development as well as low points such as the unequal distribution of those resources globally and confused messaging revealing weaknesses in how public-health authorities communicate.

Out of the many lessons learned, some important ones include the need for global zoonoses monitoring, obtaining and sharing the genetic sequences of viruses globally as they emerge, strengthening the manufacturing of diagnostics and vaccines, developing vaccines for rapid production in advance, and stopping the spread right away at its origin. Newer advancements like machine learning and climate modeling could be very useful for achieving such goals, especially in predicting infectious-disease outbreaks.

In summary, preparing for future pandemics involves strengthening the entire chain of the outbreak response, from identifying a pathogen with proper diagnostics to timely mass vaccination.

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Although serious illness and hospitalization from severe COVID are remarkedly low, the recent rise of Omicron Subvariant XBB.1.5 is highly concerning.

First detected last October in the US, XBB.1.5 has been circulating in at least 38 countries, including Canada, Australia, Kuwait, Germany, and France, and now accounts for 43% of the COVID-19 cases in the US for the week ending Jan 14, a sharp rise from only 27.6% and 18.3% for the week ending Jan 7 and Dec 31 respectively.

XBB.1.5, unofficially named Kraken, is a combination of two strains of the subvariant BA.2. On Jan 4, WHO called this the “most transmissible subvariant detected yet”. WHO has no definitive evidence that Kraken will lead to more severe disease than its predecessors. However, since the mutations within this subvariant of Omicron allow this virus to adhere to the cell and replicate more quickly, scientists warn everyone to be highly vigilant till definitive evidence arises in either direction.

Since the bivalent vaccine, which includes a combination of the original virus and the Omicron variant, continues to provide “good protection” including against XBB strains in terms of preventing severe acute disease, scientists urge everyone to get boosted ASAP.

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The news that the FDA accepted licensing application from Astrazeneca/Sanofi for its expedited review for a single-dose long-acting antibody (Nirsevimab) is highly encouraging. This is indicated to prevent Respiratory Syncytial Virus (RSV) infections in newborns and infants entering or during their first RSV season, as well as children aged up to 24 months who are vulnerable to severe RSV disease through to their second RSV season.

Nirsevimab demonstrated up to 74.5% reduction in lower-respiratory tract infections, such as bronchiolitis or pneumonia, caused by RSV, and would become the first and only single-dose, passive immunization for a broad newborn and infant population in the US. This brings us one step closer to providing an effective protective option against this incredibly contagious disease responsible for the hospitalization of babies less than 1 year of age. This has already been approved in Europe and if everything goes well, it is expected to be approved in the US by the third quarter – just in time for the 2023/24 RSV season. Till then, scientists reiterate the importance of quickly and properly identifying pathogens by using tests like Acutis Reveal™ respiratory infection test (RIT) that can detect up to 22 major respiratory pathogens including RSV A and B within 24 hours.

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Antimicrobial Resistance (AMR) is an unintended natural phenomenon that occurs when microorganisms are exposed to drugs. It is a growing health threat, and without prompt action to develop new antimicrobial modalities and therapies, it is projected to kill ~10 million people per year by 2050.

Since microorganisms evolve quickly, pathogens have adopted even the last resort antibiotics. This necessitates the urgent discovery of newer agents with a different mode of action than those that have developed AMR while maintaining, and/or improving the efficacy of existing antibiotics. In an eloquent study, scientists developed hemithioindigo (HTI)-based molecular machines capable of specifically killing growing bacteria and antibiotic-tolerant persister cells of deadly bacteria like Methicillin-Resistant Staphylococcus aureus (MRSA) within minutes of activation with visible light, including the elimination of biofilms of S. aureus and Bacillus subtilis in as little as 1 hour after light activation, and without causing any harm to mammalian cells. While these are promising developments, as of today diagnosing infections promptly using prominent diagnostic kits like Acutis Reveal™, multiplex PCR-based tests covering a wide array of pathogens, are the only available measures to identify the pathogen and treat the infections promptly so as to lower the burden of AMR.

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As the winter is kicking in, scientists are worried about the compelling evidence suggesting for a surge of COVID-19 this autumn and winter. Along with a bigger comeback of RSV and Flu, the emergence of new immune-evading strains of the SARS-CoV-2 Omicron variant, behavior changes, and waning immunity are more likely to push the infection rates higher. Scientists are exploring the factors that might drive a COVID-19 wave and the ways to minimize the effects with the new generation of vaccines and other preventive measures.

For individuals and public health agencies to get well prepared, scientists are digging into basic questions like whether will there be a COVID-19 wave this autumn and winter, are new variants behind rising case numbers, will we see a new Omicron strain this autumn, why are these variants on the rise, how big will autumn–winter waves be, what about the new vaccines, etc. Although evidence hinges towards a potential surge, fortunately, COVID-19 vaccines, both old and new, remain highly effective in preventing severe diseases and death, thus urging for concentrated booster campaigns on those at the highest risk of severe disease, including older and immunocompromised people, who will benefit the most from the added protection.

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